Propylthiouraci是甲状腺过氧化物酶和5'-脱碘酶抑制剂。
Propylthiouracil is a thyroperoxidase and 5'-deiodinase inhibitor, used to treat hyperthyroidism.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Sener G, et al. J Endocrinol,?006, 189(2), 257-269.
分子式 C7H10N2OS |
分子量 170.23 |
CAS号 51-52-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 34 mg/mL |
Water <1 mg/mL |
Ethanol 20 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01097915 | Dysgeusia | University of Cagliari | 2009-10-01 | 2016-12-21 | ||
NCT01436994 | Paediatric Thyrotoxicosis | Procedure: Block and Replace|Procedure: Dose Titration|Drug: carbimazole|Drug: propylthiouracil|Drug: thyroxine | Newcastle-upon-Tyne Hospitals NHS Trust | Phase 3 | 2004-07-01 | 2016-09-20 |
NCT02812888 | Hyperthyroidism | Drug: thionamide treatment for 3 months | Hu Hao|The First People's Hospital of Xuzhou | 2016-07-01 | 2016-07-05 | |
NCT03066076 | Graves Disease|Graves Ophthalmopathy|Graves' Ophthalmopathy Worsened | Drug: Antithyroid Drug|Procedure: Total thyroidectomy | Medical University of Vienna | Phase 3 | 2017-03-01 | 2017-02-22 |
NCT02390180 | Taste Qualities|Primary Tastes | Other: Tasting solutions | Purdue University | 2014-10-01 | 2015-05-11 | |
NCT01056419 | Graves' Ophthalmopathy | Procedure: Total Thyroidectomy|Drug: Propylthiouracil | Ankara University | Phase 4 | 2009-01-01 | 2010-01-25 |
NCT00570466 | Type 2 Diabetes | Behavioral: Behavior Change Video Games|Behavioral: Control group | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Baylor College of Medicine | 2008-01-01 | 2014-09-25 | |
NCT00846755 | Thyroid Disease|Pregnancy | Drug: Levothyroxine, Propylthiouracile | Ospedale V. Fazzi | 2005-03-01 | 2011-09-26 | |
NCT02993302 | Graves Disease | Drug: 1伪-D3|Drug: Placebos | Dr Cipto Mangunkusumo General Hospital|Indonesia University | Phase 2 | 2014-07-01 | 2016-12-12 |
NCT01801033 | Hypothyroidism|Thyroidectomy | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) | 2013-01-04 | 2017-01-24 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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