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Propylthiouracil

丙基硫氧嘧啶,NSC 6498,NSC 70461,NSC-70461,NSC70461,NSC-6498,NSC6498,

Propylthiouraci是甲状腺过氧化物酶和5'-脱碘酶抑制剂。

目录号
EY1642
EY1642
纯度
99.51%
99.51%
规格
100 mg
500 mg
原价
580
880
售价
580
880
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Propylthiouracil is a thyroperoxidase and 5'-deiodinase inhibitor, used to treat hyperthyroidism.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Sener G, et al. J Endocrinol,?006, 189(2), 257-269.

    分子式
    C7H10N2OS
    分子量
    170.23
    CAS号
    51-52-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    34 mg/mL
    Water
    <1 mg/mL
    Ethanol
    20 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01097915 Dysgeusia University of Cagliari 2009-10-01 2016-12-21
    NCT01436994 Paediatric Thyrotoxicosis Procedure: Block and Replace|Procedure: Dose Titration|Drug: carbimazole|Drug: propylthiouracil|Drug: thyroxine Newcastle-upon-Tyne Hospitals NHS Trust Phase 3 2004-07-01 2016-09-20
    NCT02812888 Hyperthyroidism Drug: thionamide treatment for 3 months Hu Hao|The First People's Hospital of Xuzhou 2016-07-01 2016-07-05
    NCT03066076 Graves Disease|Graves Ophthalmopathy|Graves' Ophthalmopathy Worsened Drug: Antithyroid Drug|Procedure: Total thyroidectomy Medical University of Vienna Phase 3 2017-03-01 2017-02-22
    NCT02390180 Taste Qualities|Primary Tastes Other: Tasting solutions Purdue University 2014-10-01 2015-05-11
    NCT01056419 Graves' Ophthalmopathy Procedure: Total Thyroidectomy|Drug: Propylthiouracil Ankara University Phase 4 2009-01-01 2010-01-25
    NCT00570466 Type 2 Diabetes Behavioral: Behavior Change Video Games|Behavioral: Control group National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|Baylor College of Medicine 2008-01-01 2014-09-25
    NCT00846755 Thyroid Disease|Pregnancy Drug: Levothyroxine, Propylthiouracile Ospedale V. Fazzi 2005-03-01 2011-09-26
    NCT02993302 Graves Disease Drug: 1伪-D3|Drug: Placebos Dr Cipto Mangunkusumo General Hospital|Indonesia University Phase 2 2014-07-01 2016-12-12
    NCT01801033 Hypothyroidism|Thyroidectomy National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)|National Heart, Lung, and Blood Institute (NHLBI)|National Institutes of Health Clinical Center (CC) 2013-01-04 2017-01-24

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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