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Gimeracil

吉莫斯特,Gimestat

Gimeracil是二氢嘧啶脱氢酶（DPYD）抑制剂，能降解血液中的包含5-fluorouracil等的嘧啶。

目录号
EY1629
EY1629
EY1629
纯度
99.67%
99.67%
99.67%
规格
25 mg
50 mg
100 mg
原价
400
600
800
售价
400
600
800
库存
现货
现货
现货
订购
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  • 生物活性

    Gimeracil is an inhibitor of dihydropyrimidine dehydrogenase, which inhibits the early step in homologous recombination for double strand breaks repair.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Petra Matt, et al. Oncologist. 2011 Oct; 16(10): 1451–1457. Published online 2011 Sep 30. doi:10.1634/theoncologist.2011-0224.
    [2] Makoto Tahara,et al. Cancer Sci. 2015 Oct; 106(10): 1414–1420. Published online 2015 Sep 21. doi: 10.1111/cas.12764.

    分子式
    C5H4ClNO2    		 分子量
    145.54    		 CAS号
    103766-25-2    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    29 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01492543 Breast Cancer Drug: Tegafur Gimeracil Oteracil Potassium Capsule Chinese Academy of Medical Sciences|Beijing Cancer Hospital|Beijing Chao Yang Hospital|Chinese PLA General Hospital|China-Japan Friendship Hospital|Tianjin Medical University Cancer Institute and Hospital|Hebei Tumor Hospital Phase 2 2011-12-01 2013-03-14
    NCT01516944 Gastric Cancer Drug: Tegafur, Gimeracil and Oteracil Potassium Capsulesxaliplatin|Drug: Tegafur, Gimeracil and Oteracil Potassium Capsulesxaliplatin|Drug: Oxaliplatin; Capecitabine Hebei Medical University Phase 2|Phase 3 2012-02-01 2016-09-04
    NCT01285557 Metastatic Diffuse Gastric Cancer Including Carcinoma of the Gastro-esophageal Junction Drug: S-1 (Tegafur/Gimeracil/Oteracil) /cisplatin (investigational arm)|Drug: Fluorouracil/cisplatin (control arm) Taiho Oncology, Inc. Phase 3 2011-02-01 2016-10-19
    NCT02008422 Gastric Cancer Drug: Oxaliplatin|Drug: Gimeracil and Oteracil Potassium Capsule|Drug: Endostar injection Tang Xushan|Xinjiang Medical University Phase 3 2013-08-01 2013-12-06
    NCT02504229 Gastric Cancer Biological: autologous dendritic cells co-cultured with cytokine-induced killer cells|Drug: Gimeracil and Oteracil Porassium Capsules|Drug: Oxaliplatin Beijing Biohealthcare Biotechnology Co.,Ltd Phase 2 2014-11-01 2015-07-20
    NCT02024217 Gastric Cancer Radiation: S1xaliplatinadiation Fudan University Phase 2 2012-03-01 2013-12-25
    NCT00660894 Colorectal Cancer Drug: folinate calcium|Drug: tegafur-uracil|Drug: tegafur-gimeracil-oteracil potassium Translational Research Informatics Center, Kobe, Hyogo, Japan Phase 3 2008-04-01 2016-08-02
    NCT03006705 Gastric Cancer Drug: ONO-4538|Drug: Tegafur-gimeracil-oteracil potassium|Drug: Oxaliplatin|Drug: Capecitabine|Drug: Placebo Ono Pharmaceutical Co. Ltd|Bristol-Myers Squibb Phase 3 2017-01-01 2017-03-21
    NCT03002831 Advanced Cancer Biological: Cytokine-induced Killer Cells|Drug: Tegafur-Gimeracil-Oteracil Potassium Henan Cancer Hospital Phase 2 2016-11-01 2016-12-23
    NCT01655992 Metastatic Breast Cancer Drug: capecitabine|Drug: S1 generic Fudan University Phase 3 2012-01-01 2017-01-03
    NCT02746796 Gastric Cancer Drug: ONO-4538|Drug: Oxaliplatin|Drug: Tegafur- Gimeracil-Oteracil potassium|Drug: Capecitabine|Drug: Placebo Ono Pharmaceutical Co. Ltd Phase 2|Phase 3 2016-03-01 2017-02-28
    NCT00503321 Gastric Cancer Drug: Tegafur/gimeracil/oteracil potassium (S-1), Krestin (PSK)|Drug: Tegafur/gimeracil/oteracil potassium (S-1) Eastern Network of Cancer Immunological Therapy, Japan Phase 2|Phase 3 2006-10-01 2009-01-22
    NCT02277158 Rectal Cancer Drug: Chemoradiotherapy Daping Hospital and the Research Institute of Surgery of the Third Military Medical University Phase 1 2014-11-01 2014-11-30
    NCT02618356 Metastatic Colon Cancer Drug: Raltitrexed and S-1 Fudan University Phase 2 2015-12-01 2015-12-02
    NCT02945267 Unresectable Pancreatic Cancer Drug: Nimotuzumab plus S1|Drug: Placebo plus S1 Chinese PLA General Hospital Phase 4 2016-09-01 2016-10-25
    NCT02527824 Biliary Tract Neoplasm Drug: Oxaliplatin, Irinotecan, S-1 Hallym University Medical Center|Jeil Pharmaceutical Co., Ltd. Phase 2 2015-03-01 2016-09-27
    NCT02527785 Stomach Neoplasm Drug: Oxaliplatin, Irinotecan, S-1(OIS) Hallym University Medical Center|Jeil Pharmaceutical Co., Ltd. Phase 2 2015-02-01 2016-09-27
    NCT03013010 Stomach Neoplasm|GastroEsophageal Cancer|Adenocarcinoma|Locally Advanced Cancer|Chemoradiation Drug: Tegafur-Gimeracil-Oteracil Potassium|Radiation: Chemoradiotherapy|Procedure: Gastric resection|Drug: Oxaliplatin Shanghai Cancer Hospital, China|Fudan University|Ruijin Hospital|Xinhua Hospital, Shanghai Jiao Tong University School of Medicine|Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine|Huadong Hospital Phase 3 2016-12-01 2017-01-04
    NCT01388790 Gastric Cancer Drug: Cetuximab|Drug: Cisplatin|Drug: S-1 Merck KGaA Phase 2 2011-06-01 2013-09-09
    NCT00974389 Colorectal Cancer Biological: bevacizumab|Drug: tegafur-gimeracil-oteracil potassium Osaka Medical College|National Cancer Institute (NCI) Phase 2 2009-07-01 2013-08-09
    NCT00687843 Gastric Cancer Drug: Tegafur-gimeracil-oteracil potassium (TS-1)|Drug: Krestin (PSK) Tokyo Metropolitan Oncology Group Phase 3 2008-06-01 2012-03-20
    NCT00216034 Gastric Cancer Drug: Tegafur-gimeracil-oteracil potassium (TS-1)|Drug: Krestin (PSK) Hokuriku-Kinki Immunochemotherapy Study Group Phase 3 2005-03-01 2016-06-06

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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