LY2940680能结合Smoothened (Smo)受体,并抑制Hedgehog (Hh)信号传导。
Taladegib (LY2940680) binds to the Smoothened (Smo) receptor and potently inhibits Hedgehog (Hh) signaling. Phase 1/2.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Redmond EM et al. Expert Opin Investig Drugs, 2011, 20(12),1649-1664.
分子式 C26H24F4N6O |
分子量 512.5 |
CAS号 1258861-20-9 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 5 mg/mL |
Water <1 mg/mL |
Ethanol 1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02530437 | Esophageal Cancer | Drug: Taladegib|Drug: Paclitaxel|Drug: Carboplatin|Radiation: Radiation Therapy|Procedure: Endoscopy | M.D. Anderson Cancer Center|National Cancer Institute (NCI)|Eli Lilly and Company | Phase 1|Phase 2 | 2017-03-07 | 2017-03-07 |
NCT01919398 | Neoplasm Metastasis | Drug: LY2940680 | Eli Lilly and Company | Phase 1 | 2013-08-01 | 2016-08-26 |
NCT01697514 | Medulloblastoma, Childhood|Rhabdomyosarcoma | Drug: LY2940680|Drug: LY2940680 | Eli Lilly and Company | Phase 1 | 2013-07-01 | 2013-08-26 |
NCT01746745 | Healthy Volunteers | Drug: [C14]-LY2940680 | Eli Lilly and Company | Phase 1 | 2013-01-01 | 2013-03-14 |
NCT01722292 | Small Cell Lung Carcinoma | Drug: LY2940680|Drug: Carboplatin|Drug: Etoposide|Drug: Placebo | Eli Lilly and Company | Phase 1|Phase 2 | 2013-01-01 | 2015-09-30 |
NCT01681186 | Healthy Volunteers | Drug: LY2940680 Capsule(s) (Reference)|Drug: LY2940680 Tablet (Test)|Drug: Lanzoprazole|Drug: Placebo Capsule(s) | Eli Lilly and Company | Phase 1 | 2012-09-01 | 2013-01-11 |
NCT01226485 | Advanced Cancer | Drug: RXDX-109 | Ignyta, Inc. | Phase 1 | 2010-09-01 | 2016-11-08 |
NCT02784795 | Solid Tumor|Breast Cancer|Colon Cancer|Cholangiocarcinoma|Soft Tissue Sarcoma | Drug: LY3039478|Drug: Taladegib|Drug: Abemaciclib|Drug: Cisplatin|Drug: Gemcitabine|Drug: Carboplatin|Drug: LY3023414 | Eli Lilly and Company | Phase 1 | 2016-11-01 | 2017-03-27 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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