Home > others & > Pimecrolimus

Pimecrolimus

吡美莫司,ASM 981,ASM981,ASM-981

Pimecrolimus是免疫亲和素（immunophilin）配体，能特异地与胞质受体（immunophilin macrophilin-12）相结合。

目录号
EY1616
EY1616
EY1616
EY1616
纯度
99.33%
99.33%
99.33%
99.33%
规格
5 mg
10 mg
50 mg
100 mg
原价
462
750
880
1300
售价
462
750
880
1300
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
具体折扣请咨询客服

  • 生物活性

    Pimecrolimus, like all ascomycins, is an immunophilin ligand, which binds specifically to the cytosolic receptor, immunophilin macrophilin-12.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Nghiem P, et al. Am Acad Dermatol, 2002, 46(2), 228-241.

    分子式
    C43H68ClNO11    		 分子量
    810.45    		 CAS号
    137071-32-0    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    100 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    100 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00509990 Atopic Dermatitis Drug: Pimecrolimus Novartis Pharmaceuticals|Novartis Phase 4 2005-04-01 2017-03-24
    NCT00568997 Atopic Dermatitis Drug: Pimecrolimus Valeant Pharmaceuticals International, Inc.|Clinical Research Computing Unit (University of Pennsylvania) 2004-06-01 2015-01-20
    NCT01692626 Rash Drug: Pimecrolimus|Drug: Placebo West Virginia University Phase 2 2012-02-01 2017-01-24
    NCT00117377 Atopic Dermatitis Drug: Pimecrolimus|Drug: Placebo Novartis Phase 4 2004-04-01 2007-12-13
    NCT00351052 Atopic Dermatitis Drug: Pimecrolimus|Drug: Placebo Novartis Phase 3 2001-12-01 2008-01-15
    NCT00297037 Oral Lichen Planus Drug: Pimecrolimus 1% cream University of Utah|Novartis Phase 2 2005-08-01 2012-09-14
    NCT00510003 Atopic Dermatitis Drug: Pimecrolimus Novartis Pharmaceuticals|Novartis Phase 4 2004-12-01 2016-11-16
    NCT00367393 Atopic Dermatitis Drug: Pimecrolimus cream 1% Novartis Phase 4 2006-03-01 2017-02-22
    NCT00139581 Atopic Dermatitis Drug: Pimecrolimus|Drug: Pimecrolimus Novartis Phase 4 2004-09-01 2008-04-22
    NCT00232115 Perioral Dermatitis Drug: Pimecrolimus|Drug: Placebo Novartis Phase 3 2005-09-01 2008-01-15
    NCT00231998 Atopic Dermatitis Drug: Pimecrolimus Novartis Phase 3 2004-05-01 2007-12-13
    NCT00925730 Atopic Dermatitis Drug: Pimecrolimus Novartis Phase 4 2004-03-01 2016-11-16
    NCT00120523 Atopic Dermatitis Drug: Pimecrolimus|Drug: Topical corticosteroids MEDA Pharma GmbH & Co. KG Phase 3 2004-04-01 2016-04-26
    NCT00121316 Atopic Dermatitis Drug: Pimecrolimus|Drug: Placebo Novartis Phase 4 2004-10-01 2008-01-10
    NCT00121381 Dermatitis, Atopic Drug: Pimecrolimus plus topical corticosteroid (TCS)|Drug: Pimecrolimus vehicle (Placebo) plus topical corticosteroid (TCS) Novartis Phase 4 2005-05-01 2008-01-10
    NCT00208026 Netherton Syndrome Drug: Pimecrolimus 1% Cream Children's Hospital of Philadelphia|Novartis Pharmaceuticals Phase 1|Phase 2 2005-09-01 2014-12-06
    NCT00130364 Atopic Dermatitis Drug: Pimecrolimus|Drug: Placebo Novartis Phase 4 2005-08-01 2008-01-10
    NCT00232011 Atopic Dermatitis Drug: Pimecrolimus Cream 1% Novartis Phase 3 2004-05-01 2007-12-13
    NCT00124709 Atopic Dermatitis Drug: Pimecrolimus|Drug: Corticosteroid Novartis Pharmaceuticals|Novartis Phase 4 2003-10-01 2011-02-25
    NCT00946478 Atopic Dermatitis Drug: Pimecrolimus|Other: Vehicle cream University of California, San Diego|Novartis 2009-10-01 2014-01-27
    NCT00810862 Atopic Dermatitis Drug: pimecrolimus active cream|Other: placebo base cream Children's Hospital of Michigan|Novartis Pharmaceuticals Phase 4 2006-11-01 2008-12-17
    NCT00608673 Discoid Lupus Erythematosus Drug: Pimecrolimus 1% cream|Drug: betamethasone valerate 0.1% cream Shahid Beheshti University of Medical Sciences 2006-04-01 2008-02-06
    NCT00226707 Chronic Hand Dermatitis Drug: Pimecrolimus Cream 1% Novartis Phase 3 2004-07-01 2008-02-13
    NCT01177566 Atopic Dermatitis Drug: pimecrolimus|Device: topical medical device Emer, Jason, M.D.|Ferndale Laboratories Phase 4 2009-09-01 2010-08-05

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 ：
  • 收件地址 ：
  • 电话号码 ：
  • 单位名称 ：
  • 产品货号 ：
  • 产品规格 ：
  • 发票抬头以及单位税号 ：