Home > others & > FH1

FH1

BRD-K4477,BRD K4477,BRDK4477,FH-1,FH 1,

FH1是一种小分子能增强肝细胞的功能。

目录号
EY1611
EY1611
EY1611
EY1611
纯度
99.75%
99.75%
99.75%
99.75%
规格
5 mg
10 mg
50 mg
100 mg
原价
299
480
1720
2960
售价
299
480
1720
2960
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    FH1 (BRD-K4477) is a small molecule, which promotes differentiation of iPS-derived hepatocytes.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Shan J, et al. Nat Chem Biol. 2013, 9(8), 514-520.

    分子式
    C17H18N2O2
    分子量
    282.34
    CAS号
    2719-05-3
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    58 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00443144 Turner Syndrome|Short Stature Drug: recombinant human growth hormone University Hospital Tuebingen 2005-05-01 2015-12-02
    NCT01325246 Ventral Hernia University Hospital Koge 2010-09-01 2013-12-03
    NCT01177644 Age-Related Macular Degeneration Drug: PDS 1.0 Forsight Vision4 Phase 1 2011-01-01 2012-08-21
    NCT02071862 Solid Tumors|Triple-Negative Breast Cancer|Non Small Cell Lung Cancer|Renal Cell Carcinoma|Mesothelioma|Fumarate Hydratase (FH)-Deficient Tumors|Succinate Dehydrogenase (SDH)-Deficient Gastrointestinal Stromal Tumors (GIST)|Succinate Dehydrogenase (SDH)-Deficient Non-gastrointestinal Stromal Tumors|Tumors Harboring Isocitrate Dehydrogenase-1 (IDH1) and IDH2 Mutations|Tumors Harboring Amplifications in the cMyc Gene Drug: CB-839|Drug: Pac-CB|Drug: CBE|Drug: CB-Erl|Drug: CBD|Drug: CB-Cabo Calithera Biosciences, Inc Phase 1 2014-02-01 2016-08-18
    NCT01430676 Incisional Hernia Procedure: differences in surgical techniques University Hospital Koge 2007-01-01 2011-11-30
    NCT00050752 Renal Tumor Histology|Cutaneous Leiomyomatosis|Kidney Cancer National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) 2002-12-17 2017-01-24
    NCT03033953 Healthy|Young|Elderly Dietary Supplement: Native whey|Dietary Supplement: Milk|Other: Strength training Norwegian School of Sport Sciences|Tine|The Research Council of Norway 2014-08-01 2017-01-24
    NCT02495103 Renal Cell Carcinoma|Hereditary Leiomyomatosis and Renal Cell Cancer|Papillary Renal Cell Carcinoma, Sporadic Drug: Vandetanib|Drug: Metformin National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) Phase 1|Phase 2 2015-06-30 2017-01-24

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 :
  • 收件地址 :
  • 电话号码 :
  • 单位名称 :
  • 产品货号 :
  • 产品规格 :
  • 发票抬头以及单位税号 :