FH1是一种小分子能增强肝细胞的功能。
FH1 (BRD-K4477) is a small molecule, which promotes differentiation of iPS-derived hepatocytes.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Shan J, et al. Nat Chem Biol. 2013, 9(8), 514-520.
分子式 C17H18N2O2 |
分子量 282.34 |
CAS号 2719-05-3 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 58 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00443144 | Turner Syndrome|Short Stature | Drug: recombinant human growth hormone | University Hospital Tuebingen | 2005-05-01 | 2015-12-02 | |
NCT01325246 | Ventral Hernia | University Hospital Koge | 2010-09-01 | 2013-12-03 | ||
NCT01177644 | Age-Related Macular Degeneration | Drug: PDS 1.0 | Forsight Vision4 | Phase 1 | 2011-01-01 | 2012-08-21 |
NCT02071862 | Solid Tumors|Triple-Negative Breast Cancer|Non Small Cell Lung Cancer|Renal Cell Carcinoma|Mesothelioma|Fumarate Hydratase (FH)-Deficient Tumors|Succinate Dehydrogenase (SDH)-Deficient Gastrointestinal Stromal Tumors (GIST)|Succinate Dehydrogenase (SDH)-Deficient Non-gastrointestinal Stromal Tumors|Tumors Harboring Isocitrate Dehydrogenase-1 (IDH1) and IDH2 Mutations|Tumors Harboring Amplifications in the cMyc Gene | Drug: CB-839|Drug: Pac-CB|Drug: CBE|Drug: CB-Erl|Drug: CBD|Drug: CB-Cabo | Calithera Biosciences, Inc | Phase 1 | 2014-02-01 | 2016-08-18 |
NCT01430676 | Incisional Hernia | Procedure: differences in surgical techniques | University Hospital Koge | 2007-01-01 | 2011-11-30 | |
NCT00050752 | Renal Tumor Histology|Cutaneous Leiomyomatosis|Kidney Cancer | National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) | 2002-12-17 | 2017-01-24 | ||
NCT03033953 | Healthy|Young|Elderly | Dietary Supplement: Native whey|Dietary Supplement: Milk|Other: Strength training | Norwegian School of Sport Sciences|Tine|The Research Council of Norway | 2014-08-01 | 2017-01-24 | |
NCT02495103 | Renal Cell Carcinoma|Hereditary Leiomyomatosis and Renal Cell Cancer|Papillary Renal Cell Carcinoma, Sporadic | Drug: Vandetanib|Drug: Metformin | National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC) | Phase 1|Phase 2 | 2015-06-30 | 2017-01-24 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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