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Hesperidin

橙皮甙,Cirantin

Hesperidin是在柑橘类水果中广泛存在的黄酮苷。

目录号
EY1610
EY1610
EY1610
EY1610
EY1610
纯度
99.44%
99.44%
99.44%
99.44%
99.44%
规格
5 mg
10 mg
50 mg
100 mg
500 mg
原价
305
498
860
1150
1800
售价
305
498
860
1150
1800
库存
现货
现货
现货
现货
现货
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  • 生物活性

    Hesperidin is a flavanone glycoside found abundantly in citrus fruits.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Yang, M., et al., 1997. Chemopreventive effects of diosmin and hesperidin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary-bladder carcinogenesis in male ICR mice. International journal of cancer. Journal international du cancer. 73(5): 719-24. PMID: 9398052
    [2] Tanaka, T., et al., 1997. Chemoprevention of azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin and hesperidin. Carcinogenesis. 18(5): 957-65. PMID: 9163681
    [3] Tanaka, T., et al., 1997. Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis in rats by flavonoids diosmin and hesperidin, each alone and in combination. Cancer research. 57(2): 246-52. PMID: 9000563
    [4] Wanpeng Xi et. Al. Food Chemistry, 161, 230-238 (2014).
    [5] George Man et. Al. Experimental Dermatology, 23(9), 645-651 (2014).
    [6] Otilia J F Banji et. Al. Food and Chemical Toxicology, 74, 51-59 (2014).

    分子式
    C28H34O15    		 分子量
    610.56    		 CAS号
    520-26-3    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    122 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01881204 Osteoporosis, Postmenopausal Dietary Supplement: Hesperidin and Calcilock|Dietary Supplement: Hesperidin|Dietary Supplement: Control Purdue University|Nestec Ltd. 2011-04-01 2013-06-17
    NCT00914251 Endothelial Dysfunction|Metabolic Syndrome Drug: Hesperidin|Drug: Placebo University of Rome Tor Vergata Phase 2 2008-11-01 2009-06-16
    NCT01773486 Obesity|Insulin Resistance Drug: Hesperidin|Drug: Placebo University of Maryland Phase 2 2015-06-01 2016-01-28
    NCT00545116 Osteopenia|Osteoporosis Other: Hesperidin Nestl|National University of Malaysia Phase 2 2007-10-01 2015-10-05
    NCT02610491 Metabolic Syndrome|Obesity Dietary Supplement: Hesperidin|Dietary Supplement: Placebo Maastricht University Medical Center Phase 2 2015-02-01 2015-11-19
    NCT02927483 Chronic Venous Insufficiency Dietary Supplement: Endolex Forte|Dietary Supplement: A combination of diosmin and hesperidin SunWave Pharma|Opera Contract Research Organization SRL Phase 3 2016-11-01 2016-10-27
    NCT00330096 Osteoporosis, Osteopenia Drug: Hesperidin|Other: Placebo Nestl|Institut National de la Recherche Agronomique|Centre de Recherche en Nutrition Humaine. Clermont-Ferrand, France Phase 3 2006-03-01 2015-10-28
    NCT02479568 Cardiovascular Risk Factors Dietary Supplement: Control|Dietary Supplement: 100% Florida OJ|Dietary Supplement: 100% Florida OJ-enriched Technological Centre of Nutrition and Health, Spain|Florida Department of Citrus|Technological Centre of Nutrition and Health|Hospital Universitari Sant Joan de Reus|University Rovira i Virgili Phase 3 2015-09-01 2016-06-03
    NCT02907320 Venous Disease Classification (CEAP): C2 or C3 Drug: CYCLO 3  FORT|Drug: MPFF|Drug: placebo CYCLO 3  FORT|Drug: placebo MPFF Pierre Fabre Medicament|Eurotrials Brasil Consultores Cientificos Ltda Phase 2 2016-12-01 2017-02-17
    NCT01110512 Venous Insufficiency Drug: Flavonid|Drug: Daflon Azidus Brasil Phase 3 2010-10-01 2010-10-26
    NCT01477281 Chronic Venous Insufficiency|Disease Drug: Daflon|Drug: Venaflon (Diosmin and Hesperidin) Laboratrio Teuto Brasileiro S/A Phase 3 2012-02-01 2011-11-18
    NCT02380144 Healthy Other: Fresh orange fruit and pasteurized fruit juice University of Hohenheim 2014-01-01 2016-10-30

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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