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Meropenem

美罗培南,美洛培南,SM 7338,SM7338,SM-7338

Meropenem是碳青霉烯类广谱抗菌素。

目录号
EY1605
EY1605
纯度
99.19%
99.19%
规格
50 mg
100 mg
原价
480
692
售价
480
692
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Meropenem is an ultra-broad spectrum injectable antibiotic.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Edwards JR, et al. J Antimicrob Chemother, 1995, 36 Suppl A, 1-17.

    分子式
    C17H25N3O5S
    分子量
    383.46
    CAS号
    96036-03-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    77 mg/mL
    Water
    8 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01158937 Cystic Fibrosis Pulmonary Exacerbation Drug: Meropenem Infusion St. Michael's Hospital, Toronto|Sunnybrook Health Sciences Centre|University of Toronto 2010-05-01 2015-05-20
    NCT01554124 Meningitis Drug: Meropenem PENTA Foundation|Chiesi Farmaceutici S.p.A. Phase 1|Phase 2 2013-02-01 2015-02-12
    NCT01429259 Cystic Fibrosis|Pneumonia|Pseudomonas Aeruginosa Infection Drug: meropenem Joseph Kuti|Thrasher Research Fund|Hartford Hospital Phase 4 2012-02-01 2015-03-26
    NCT00621192 Necrotizing Enterocolitis|Intra-abdominal Infection Drug: meropenem Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|The EMMES Corporation Phase 1|Phase 2 2008-06-01 2015-03-30
    NCT02506686 Central Nervous System Infections Drug: Meropenem Huashan Hospital Phase 4 2008-09-01 2015-07-21
    NCT01944319 Lower Respiratory Tract Infection Drug: Routine meropenem therapy|Drug: Meropenem therapy based on a PPK and PD model Qingtao Zhou|Peking University Third Hospital Phase 4 2013-07-01 2016-01-28
    NCT02615041 Ventilator-Associated Pneumonia Drug: Meropenem|Drug: Meropenem|Drug: Meropenem Sutep Jaruratanasirikul|Prince of Songkla University Phase 4 2004-01-01 2015-11-24
    NCT02437045 Bloodstream Infections Drug: Meropenem|Drug: Piperacillin-tazobactam combination product The University of Queensland Phase 4 2015-04-01 2016-11-13
    NCT00891423 Sepsis Drug: Meropenem short infusion|Drug: Meropenem extended infusion Austin Health 2009-04-01 2015-07-30
    NCT02213796 Initial Phase of Severe Sepsis and Septic Shock Drug: Meropenem Sutep Jaruratanasirikul|Prince of Songkla University Phase 4 2013-01-01 2014-08-08
    NCT01551394 Sepsis Drug: Meropenem|Drug: Ampicillin + gentamicin or cefotaxime + gentamicin PENTA Foundation|Chiesi Farmaceutici S.p.A. Phase 3 2012-09-01 2015-02-12
    NCT01732250 Gram-Negative Bacterial Infections Drug: Colistin|Drug: Meropenem Mical Paul|European Commission|Rabin Medical Center Phase 4 2013-03-01 2016-12-17
    NCT00534287 Severe Sepsis|Septic Shock Drug: meropenem|Drug: meropenem, moxifloxacin Kompetenznetz Sepsis|AstraZeneca|Bayer Phase 3 2007-10-01 2012-06-28
    NCT02176122 Bloodstream Infections Drug: Meropenem|Drug: Piperacillin-tazobactam combination product The University of Queensland|International Society of Chemotherapy|Australian Society for Antimicrobials|Queensland Clinical Trials & Biostatistics Centre|Australasian Society for Infectious Diseases Phase 4 2014-02-01 2016-11-15
    NCT01292031 Ventilator-associated Bacterial Pneumonia Drug: Colistin|Drug: Meropenem Fundacin Pblica Andaluza para la gestin de la Investigacin en Sevilla|European Commission Phase 3 2012-05-01 2016-02-02
    NCT01289249 Bacterial Infection Oslo University Hospital 2011-01-01 2014-11-05
    NCT02048163 Cystic Fibrosis Dayton Children's Hospital Phase 4 2013-12-01 2016-02-04
    NCT02687906 Bacterial Infections Drug: Carbavance Rempex Pharmaceuticals (a wholly owned subsidiary of The Medicines Company)|Department of Health and Human Services Phase 1 2016-07-01 2016-12-01
    NCT00579956 Melioidosis Drug: Meropenem|Drug: Ceftazidime University of Oxford|Mahidol University|Wellcome Trust 2007-12-01 2008-06-03
    NCT00318994 Pancreatitis Drug: Meropenem AstraZeneca Phase 4 2002-02-01 2008-01-11

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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