Cilnidipine是L型和N型钙离子阻断剂,有降压,神经保护活性。
Cilnidipine is a unique L-type and N-type calcium channel blocker, used for high blood pressure treatment.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Takahara A, et al. Hypertens Res,?003, 26(9), 743-747.
分子式 C27H28N2O7 |
分子量 492.52 |
CAS号 132203-70-4 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO >30 mg/mL |
Water <1 mg/mL |
Ethanol 20 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00325637 | Hypertension|Stroke | Drug: cilnidipine | Boryung Pharmaceutical Co., Ltd | Phase 3 | 2005-01-01 | 2008-12-11 |
NCT00325936 | Hypertension|Metabolic Syndrome X | Drug: Cilnidipine | Boryung Pharmaceutical Co., Ltd | Phase 4 | 2005-07-01 | 2008-08-26 |
NCT02343250 | Hypertension | Drug: Cilnidipine/Valsartan|Drug: Cilnidipine+Valsartan|Drug: Cilnidipine/Valsartan|Drug: Cilnidipine+Valsartan | IlDong Pharmaceutical Co Ltd | Phase 1 | 2015-03-01 | 2016-01-11 |
NCT02088008 | Healthy Volunteers | Drug: cinidipine, valsartan | IlDong Pharmaceutical Co Ltd | Phase 1 | 2014-05-01 | 2014-03-12 |
NCT01838967 | Healthy | Drug: C - V - C+V|Drug: C - C+V - V|Drug: V - C - C+V|Drug: V - C+V - C|Drug: C+V - C - V|Drug: C+V - V - C | IlDong Pharmaceutical Co Ltd | Phase 1 | 2013-04-01 | 2013-10-11 |
NCT02145104 | Hypertension | Drug: valsartan 160mg, cilnidipine 10mg, cilinidipine 5mg | IlDong Pharmaceutical Co Ltd | Phase 3 | 2014-05-01 | 2014-05-20 |
NCT00890279 | Kidney, Polycystic, Autosomal Dominant | Drug: Cilnidipine|Drug: Imidapril | Ministry of Health, Labour and Welfare, Japan | Phase 2 | 2009-07-01 | 2009-12-01 |
NCT00541853 | Kidney, Polycystic, Autosomal Dominant | Drug: Candesartan|Drug: Candesartan and Cilnidipine|Drug: Candesartan plus non-CCB agents | Kyorin University|Ministry of Health, Labour and Welfare, Japan | Phase 4 | 2007-12-01 | 2007-10-17 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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