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Amiodarone HCl

盐酸胺碘酮

Amiodarone hydrochloride is a lipophilic antiarrhythmic/antianginal drug which is able to influence the physicochemical status of biological lipid components.

目录号
EY1595
EY1595
EY1595
纯度
99.45%
99.45%
99.45%
规格
500 mg
1 g
5 g
原价
335
408
980
售价
335
408
980
库存
现货
现货
现货
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  • 生物活性

    Amiodarone HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Kodama I, et al. Cardiovasc Res,?997, 35(1), 13-29.

    分子式
    C25H30ClI2NO3    		 分子量
    681.77    		 CAS号
    19774-82-4    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    23 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    10 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01097330 Defibrillators, Implantable|Tachycardia, Ventricular Procedure: Ablation|Drug: Amiodarone Population Health Research Institute|St. Jude Medical|Hamilton Health Sciences Corporation Phase 3 2010-08-01 2011-08-04
    NCT02668432 New Onset Atrial Fibrillation|Severe Sepsis|Septic Shock Drug: Amiodarone The University of Texas Health Science Center at San Antonio Phase 4 2016-05-01 2016-05-27
    NCT00845780 Persistent Atrial Fibrillation Drug: withdrawal or continuation of amiodarone therapy University Medical Center Groningen Phase 4 2000-08-01 2009-06-23
    NCT01817439 Atrial Fibrillation Drug: Amiodarone Western Galilee Hospital-Nahariya Phase 3 2013-05-01 2013-03-22
    NCT01422148 Atrial Fibrillation Drug: Amiodarone|Drug: Minocycline Baystate Medical Center 2011-10-01 2017-01-30
    NCT00724581 Atrial Fibrillation Drug: Amiodarone Aarhus University Hospital Phase 4 2008-08-01 2008-07-28
    NCT01173809 Atrial Fibrillation Drug: Amiodarone|Drug: Amiodarone Texas Cardiac Arrhythmia Research Foundation|University of Kansas|California Pacific Medical Center|Stanford University|Case Western Reserve University|Southlake Regional Health Centre|Catholic University, Italy Phase 3 2010-10-01 2014-08-20
    NCT01266681 Atrial Fibrillation Drug: amiodarone|Drug: Dronedarone Eastbourne General Hospital 2011-03-01 2010-12-23
    NCT00668759 Atrial Fibrillation Drug: Vernakalant Injection|Drug: Amiodarone Injection: Cardiome Pharma Phase 3 2008-04-01 2009-12-12
    NCT00587483 Other Intraoperative Cardiac Functional Disturbances During Cardiac Surgery Drug: Lidocaine|Drug: Amiodarone|Drug: Placebo Mayo Clinic 2007-11-01 2011-08-09
    NCT00313443 Arrhythmia|Atrial Fibrillation|Atrial Flutter Procedure: Fat tissue needle aspiration Hopital Lariboisire|Unit de Recherches Therapeutiques - H. Lariboisiere Phase 4 2006-04-01 2011-07-06
    NCT00420953 Healthy Drug: Cordarone Prism Pharmaceuticals Phase 1 2006-12-01 2008-01-14
    NCT01276093 Atrial Fibrillation Procedure: PVI ablation|Drug: Amiodarone St. Jude Medical 2011-07-01 2015-12-28
    NCT00489736 Atrial Fibrillation Drug: dronedarone (SR33589)|Drug: amiodarone Sanofi Phase 3 2007-06-01 2010-02-15
    NCT01627106 Atrial Fibrillation Drug: Vernakalant|Drug: Amiodarone Cardiome Pharma Phase 4 2012-09-01 2013-08-23
    NCT02307591 Ebola Virus Disease Drug: Best Supportive Care|Drug: Best Supportive Care + Amiodarone Emergency NGO Onlus Phase 2|Phase 3 2014-12-01 2015-10-05
    NCT01722942 Chagas Cardiomyopathy|Non-sustained Ventricular Tachycardia|At Least 10 Points in Rassi Risk Score for Death Procedure: ICD implantation|Drug: amiodarone hydrochloride InCor Heart Institute|Ministry of Health, Brazil|St. Jude Medical|Fundao de Amparo Pesquisa do Estado de So Paulo 2014-10-01 2014-09-08
    NCT02750319 Thoracic Surgery|Atrial Fibrillation in High Risk Patients Drug: Amiodarone|Drug: N-Acetylcysteine|Drug: Placebo Memorial Sloan Kettering Cancer Center|Washington University School of Medicine|The Cleveland Clinic|Vanderbilt University School of Medicine Phase 3 2016-04-01 2016-09-20
    NCT00729911 Heart Failure Procedure: Atrial Fibrillation ablation|Drug: Amiodarone Texas Cardiac Arrhythmia Research Foundation|Casa Sollievo della Sofferenza IRCCS|Catholic University, Italy|Southlake Regional Health Centre|Stanford University|University of Kansas|The University of Texas Medical Branch, Galveston|University of Foggia|Sutter Health Phase 4 2008-10-01 2016-10-17
    NCT01401647 Cardiac Arrest Drug: amiodarone|Drug: Lidocaine|Other: Normal saline University of Washington|National Heart, Lung, and Blood Institute (NHLBI)|Canadian Institutes of Health Research (CIHR)|Heart and Stroke Foundation of Canada|American Heart Association|Defence Research and Development Canada|U.S. Army Medical Research and Materiel Command Phase 3 2012-05-01 2016-12-05
    NCT00784316 Atrial Fibrillation|Cardiac Surgery Drug: metoprolol, amiodarone Kuopio University Hospital|Tampere University Hospital|Vaasa Central Hospital, Vaasa, Finland Phase 4 2007-08-01 2011-11-23
    NCT02341105 Atrial Fibrillation Procedure: Catheter ablation|Drug: Amiodarone Guy Amit|Population Health Research Institute Phase 4 2016-01-01 2016-12-09

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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