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Carvedilol

卡维地洛,卡维地罗,BM-14190,SKF 105517,BM 14190,BM14190,SKF-105517,SKF105517,

Carvedilol是非选择性β和α1阻断剂，能抑制LDL的氧化，IC50为3.8 μM。

目录号
EY1594
EY1594
纯度
99.65%
99.65%
规格
100 mg
500 mg
原价
480
965
售价
480
965
库存
现货
现货
订购
订购
订购
订购
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  • 生物活性

    Carvedilol is a non-selective beta blocker/alpha-1 blocker, used to treat congestive heart failure (CHF) and high blood pressure.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Yue TL, et al. J Pharmacol Exp Ther, 1992, 263(1), 92-98.

    分子式
    C24H26N2O4    		 分子量
    406.47    		 CAS号
    72956-09-3    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    86 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    10 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01064180 Healthy Drug: Carvedilol Dr. Reddy's Laboratories Limited Phase 1 2002-05-01 2010-02-04
    NCT01064154 Healthy Drug: Carvedilol Dr. Reddy's Laboratories Limited Phase 1 2002-05-01 2010-02-04
    NCT01383044 Variceal Bleeding Procedure: EVL + carvedilol|Drug: carvedilol E-DA Hospital Phase 4 2011-06-01 2011-06-27
    NCT01103154 Variceal Rebleeding Drug: carvedilol|Drug: nadolol + ISMN E-DA Hospital|National Science Council, Taiwan Phase 4 2005-03-01 2010-10-24
    NCT02286934 Healthy Drug: Carvedilol|Other: Isoproterenol Sensitivity Test Seoul National University Hospital|National Institute of Food and Drug Safety Evaluation, Korea Phase 1 2014-09-01 2015-06-02
    NCT01354444 Alzheimer's Disease Drug: Carvedilol|Drug: Placebo Johns Hopkins University|Icahn School of Medicine at Mount Sinai Phase 4 2011-06-01 2017-03-03
    NCT02946892 Single Ventricle|Fontan Drug: Carvedilol|Drug: Placebo University of Texas Southwestern Medical Center|American Heart Association Phase 4 2016-11-01 2016-10-25
    NCT02832089 Atrial Fibrillation Drug: oral carvedilol Andhra Medical College Phase 3 2000-12-01 2016-07-11
    NCT01171183 Cocaine Dependence|Cocaine Withdrawal Drug: controlled release carvedilol|Drug: Placebo University of Arkansas|National Institute on Drug Abuse (NIDA)|Baylor College of Medicine Phase 2 2010-08-01 2015-07-29
    NCT00493480 Cirrhosis|Portal Hypertension Drug: carvedilol|Drug: propranolol Hvidovre University Hospital Phase 3 2003-09-01 2009-08-07
    NCT02066649 Portal Hypertension Related to Cirrhosis Drug: Carvedilol|Procedure: Variceal band ligation Rutgers, The State University of New Jersey Phase 3 2017-02-01 2016-11-14
    NCT00864435 Healthy Drug: Carvedilol 12.5 mg Tablets, single dose|Drug: Coreg 12.5 mg Tablets , single dose Actavis Inc. Phase 1 2005-10-01 2010-08-13
    NCT01608893 Atrial Fibrillation Drug: Carvedilol|Drug: Metoprolol University of Calgary|Heart and Stroke Foundation of Canada|Libin Cardiovascular Institute of Alberta 2012-05-01 2016-08-24
    NCT00864149 Healthy Drug: Carvedilol 12.5 mg Tablets, single dose|Drug: Coreg 12.5 mg Tablets , single dose Actavis Inc. Phase 1 2005-10-01 2010-08-13
    NCT01557140 Chagas Cardiomyopathy|Heart Failure|Dilated Cardiomyopathy Drug: RASi plus carvedilol Federal University of Minas Gerais Phase 4 2003-05-01 2015-08-10
    NCT00776113 Healthy Drug: Carvedilol 12.5 mg tablets Ranbaxy Laboratories Limited|Ranbaxy Inc. 2003-08-01 2008-10-17
    NCT01270672 Mood Disorder|Substance-Related Disorders|Amphetamine-Related Disorders Drug: 3,4-Methylenedioxymethamphetamine|Drug: carvedilol|Drug: placebo University Hospital, Basel, Switzerland 2011-01-01 2016-01-20
    NCT00566969 Cocaine Dependence|Opiate Dependence Drug: sugar pill|Drug: Carvedilol 25 mg|Drug: Carvedilol 50 mg Yale University|National Institute on Drug Abuse (NIDA) 2007-09-01 2016-08-16
    NCT01756430 Hypertension Drug: Carvedilol SR 32mg, QD|Drug: Carvedilol SR 64mg, QD|Drug: Carvedilol IR 25mg, QD|Drug: Carvedilol IR 25mg, BID Chong Kun Dang Pharmaceutical Phase 3 2012-12-01 2014-01-13
    NCT00775619 Healthy Drug: Carvedilol 12.5 mg tablets Ranbaxy Laboratories Limited|Ranbaxy Inc. 2003-09-01 2008-10-17
    NCT01243827 Hypertension Drug: carvedilol|Drug: bisoprolol Yoshio Matsui|Jichi Medical University Phase 4 2010-11-01 2012-07-18
    NCT00834873 Healthy Drug: Carvedilol 25 mg tablets|Drug: COREG 25 mg tablets Teva Pharmaceuticals USA Phase 1 2001-12-01 2009-09-11
    NCT00834795 Healthy Drug: Carvedilol 25 mg tablets|Drug: COREG 25 mg tablets Teva Pharmaceuticals USA Phase 1 2001-12-01 2009-09-11
    NCT01070641 Portal Hypertension Drug: Carvedilol|Procedure: Esophageal variceal band ligation Aga Khan University Phase 4 2002-06-01 2010-02-17

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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