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Aurorix

吗氯贝胺,Moclamine,Ro111163

Moclobemide是可逆的单胺氧化酶(MAO)抑制剂,IC50为6.1 μM,可作用于重度抑郁症。

目录号
EY1591
EY1591
EY1591
纯度
99.23%
99.23%
99.23%
规格
5 mg
10 mg
50 mg
原价
275
440
1180
售价
275
440
1180
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Moclobemide is a MAO-A (5-HT) inhibitor with IC50 of 6.1 μM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Da Prada M, et al. J Pharmacol Exp Ther, 1989, 248(1), 400-414.

    分子式
    C13H17ClN2O2
    分子量
    268.74
    CAS号
    71320-77-9
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    55 mg/mL
    Water
    <1 mg/mL
    Ethanol
    10 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01926626 Nicotine Dependence Drug: Nicotine Patch|Drug: Moclobemide Jed E. Rose|Philip Morris USA, Inc.|National Institute on Drug Abuse (NIDA)|Duke University Phase 2 2013-09-01 2015-07-01
    NCT00534573 Clozapine-induced Hypersalivation Drug: Amisulpride, Moclobemide Beersheva Mental Health Center|Tirat Carmel Mental Health Center Phase 3 2008-11-01 2012-07-25
    NCT03010761 Addiction Drug: escitalopram|Drug: Moclobemide|Drug: Placebo - Cap China Medical University Hospital Phase 2 2016-01-01 2017-01-04
    NCT02222220 Clozapine-induced Hypersalivation Drug: Metoclopramide|Drug: placebo Beersheva Mental Health Center|Tirat Carmel Mental Health Center Phase 3 2012-01-01 2014-08-20
    NCT01962753 Elderly|Major Depression Drug: 18FAV45 University Hospital, Tours 2012-05-01 2015-02-13
    NCT00704860 Major Depression Other: Open label pharmacotherapy University of Ottawa Phase 4 2005-02-01 2011-01-18
    NCT02145988 Diabetes|Peripheral Arterial Disease Drug: DLBS1033|Drug: Placebo Dexa Medica Group Phase 2|Phase 3 2015-06-01 2016-11-15
    NCT02374567 Dementia|Depression|Schizophrenia|Psychosomatic Disorders|Anxiety Disorders Drug: Phenobarbital|Drug: Phenytoin|Drug: Carbamazepine|Drug: Oxcarbazepine|Drug: Valproic Acid|Drug: Lamotrigine|Drug: Topiramate|Drug: Gabapentin|Drug: Levetiracetam|Drug: Pregabalin|Drug: Lacosamide|Drug: Clonazepam|Drug: Biperiden|Drug: Levomepromazine|Drug: Fluphenazine|Drug: Perphenazine|Drug: Perazine|Drug: Thioridazine|Drug: Haloperidol|Drug: Melperone|Drug: Pipamperone|Drug: Bromperidol|Drug: Benperidol|Drug: Sertindole|Drug: Ziprasidone|Drug: Flupentixol|Drug: Chlorprothixene|Drug: Zuclopenthixol|Drug: Fluspirilene|Drug: Pimozide|Drug: Clozapine|Drug: Olanzapine|Drug: Quetiapine|Drug: Sulpiride|Drug: Tiapride|Drug: Amisulpride|Drug: Prothipendyl|Drug: Risperidone|Drug: Aripiprazole|Drug: Paliperidone|Drug: Diazepam|Drug: Oxazepam|Drug: Lorazepam|Drug: Bromazepam|Drug: Clobazam|Drug: Alprazolam|Drug: Hydroxyzine|Drug: Buspirone|Drug: Chloral Hydrate|Drug: Flurazepam|Drug: Nitrazepam|Drug: Triazolam|Drug: Lormetazepam|Drug: Temazepam|Drug: Midazolam|Drug: Brotizolam|Drug: Zopiclone|Drug: Zolpidem|Drug: Zaleplon|Drug: Melatonin|Drug: Clomethiazole|Drug: Diphenhydramine|Drug: Promethazine|Drug: Imipramine|Drug: Clomipramine|Drug: Opipramol|Drug: Trimipramine|Drug: Amitriptyline|Drug: Nortriptyline|Drug: Doxepin|Drug: Maprotiline|Drug: Amitriptyline oxide|Drug: Fluoxetine|Drug: Citalopram|Drug: Paroxetine|Drug: Sertraline|Drug: Fluvoxamine|Drug: Escitalopram|Drug: Tranylcypromine|Drug: Moclobemide|Drug: Mianserin|Drug: Trazodone|Drug: Mirtazapine|Drug: Bupropion|Drug: Venlafaxine|Drug: Reboxetine|Drug: Duloxetine|Drug: Agomelatine|Drug: Pyritinol|Drug: Piracetam|Drug: Donepezil|Drug: Rivastigmine|Drug: Galantamine|Drug: Memantine|Drug: Nicergoline|Drug: Acamprosate|Drug: Lithium Hannover Medical School Phase 3 2015-01-01 2017-02-23
    NCT02269540 Major Depressive Disorder Drug: Sertraline|Drug: Citalopram|Drug: N-acetylcysteine (NAC)|Drug: Existing depression medication treatment Centre for Addiction and Mental Health Early Phase 1 2014-10-01 2017-01-30
    NCT00068224 Autosomal Recessive Polycystic Kidney Disease|Congenital Hepatic Fibrosis|Caroli's Disease|Polycystic Kidney Disease|Joubert Syndrome|Cerebro-Oculo-Renal Syndromes|COACH Syndrome|Senior-Loken Syndrome|Dekaban-Arima Syndrome|Cogan Oculomotor Apraxia|Nephronophthisis|Bardet-Biedl Syndrome|Alstrom Syndrome|Oral-Facial-Digital Syndrome National Human Genome Research Institute (NHGRI)|National Institutes of Health Clinical Center (CC) 2003-09-04 2017-02-16
    NCT01544309 Hypercholesterolemia With Concomitant Type 2 Diabetes Drug: Atorvastatin|Drug: Rosuvastatin Listen Trial Group 2012-03-01 2015-03-04

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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