Moclobemide是可逆的单胺氧化酶(MAO)抑制剂,IC50为6.1 μM,可作用于重度抑郁症。
Moclobemide is a MAO-A (5-HT) inhibitor with IC50 of 6.1 μM.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Da Prada M, et al. J Pharmacol Exp Ther, 1989, 248(1), 400-414.
分子式 C13H17ClN2O2 |
分子量 268.74 |
CAS号 71320-77-9 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 55 mg/mL |
Water <1 mg/mL |
Ethanol 10 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01926626 | Nicotine Dependence | Drug: Nicotine Patch|Drug: Moclobemide | Jed E. Rose|Philip Morris USA, Inc.|National Institute on Drug Abuse (NIDA)|Duke University | Phase 2 | 2013-09-01 | 2015-07-01 |
NCT00534573 | Clozapine-induced Hypersalivation | Drug: Amisulpride, Moclobemide | Beersheva Mental Health Center|Tirat Carmel Mental Health Center | Phase 3 | 2008-11-01 | 2012-07-25 |
NCT03010761 | Addiction | Drug: escitalopram|Drug: Moclobemide|Drug: Placebo - Cap | China Medical University Hospital | Phase 2 | 2016-01-01 | 2017-01-04 |
NCT02222220 | Clozapine-induced Hypersalivation | Drug: Metoclopramide|Drug: placebo | Beersheva Mental Health Center|Tirat Carmel Mental Health Center | Phase 3 | 2012-01-01 | 2014-08-20 |
NCT01962753 | Elderly|Major Depression | Drug: 18FAV45 | University Hospital, Tours | 2012-05-01 | 2015-02-13 | |
NCT00704860 | Major Depression | Other: Open label pharmacotherapy | University of Ottawa | Phase 4 | 2005-02-01 | 2011-01-18 |
NCT02145988 | Diabetes|Peripheral Arterial Disease | Drug: DLBS1033|Drug: Placebo | Dexa Medica Group | Phase 2|Phase 3 | 2015-06-01 | 2016-11-15 |
NCT02374567 | Dementia|Depression|Schizophrenia|Psychosomatic Disorders|Anxiety Disorders | Drug: Phenobarbital|Drug: Phenytoin|Drug: Carbamazepine|Drug: Oxcarbazepine|Drug: Valproic Acid|Drug: Lamotrigine|Drug: Topiramate|Drug: Gabapentin|Drug: Levetiracetam|Drug: Pregabalin|Drug: Lacosamide|Drug: Clonazepam|Drug: Biperiden|Drug: Levomepromazine|Drug: Fluphenazine|Drug: Perphenazine|Drug: Perazine|Drug: Thioridazine|Drug: Haloperidol|Drug: Melperone|Drug: Pipamperone|Drug: Bromperidol|Drug: Benperidol|Drug: Sertindole|Drug: Ziprasidone|Drug: Flupentixol|Drug: Chlorprothixene|Drug: Zuclopenthixol|Drug: Fluspirilene|Drug: Pimozide|Drug: Clozapine|Drug: Olanzapine|Drug: Quetiapine|Drug: Sulpiride|Drug: Tiapride|Drug: Amisulpride|Drug: Prothipendyl|Drug: Risperidone|Drug: Aripiprazole|Drug: Paliperidone|Drug: Diazepam|Drug: Oxazepam|Drug: Lorazepam|Drug: Bromazepam|Drug: Clobazam|Drug: Alprazolam|Drug: Hydroxyzine|Drug: Buspirone|Drug: Chloral Hydrate|Drug: Flurazepam|Drug: Nitrazepam|Drug: Triazolam|Drug: Lormetazepam|Drug: Temazepam|Drug: Midazolam|Drug: Brotizolam|Drug: Zopiclone|Drug: Zolpidem|Drug: Zaleplon|Drug: Melatonin|Drug: Clomethiazole|Drug: Diphenhydramine|Drug: Promethazine|Drug: Imipramine|Drug: Clomipramine|Drug: Opipramol|Drug: Trimipramine|Drug: Amitriptyline|Drug: Nortriptyline|Drug: Doxepin|Drug: Maprotiline|Drug: Amitriptyline oxide|Drug: Fluoxetine|Drug: Citalopram|Drug: Paroxetine|Drug: Sertraline|Drug: Fluvoxamine|Drug: Escitalopram|Drug: Tranylcypromine|Drug: Moclobemide|Drug: Mianserin|Drug: Trazodone|Drug: Mirtazapine|Drug: Bupropion|Drug: Venlafaxine|Drug: Reboxetine|Drug: Duloxetine|Drug: Agomelatine|Drug: Pyritinol|Drug: Piracetam|Drug: Donepezil|Drug: Rivastigmine|Drug: Galantamine|Drug: Memantine|Drug: Nicergoline|Drug: Acamprosate|Drug: Lithium | Hannover Medical School | Phase 3 | 2015-01-01 | 2017-02-23 |
NCT02269540 | Major Depressive Disorder | Drug: Sertraline|Drug: Citalopram|Drug: N-acetylcysteine (NAC)|Drug: Existing depression medication treatment | Centre for Addiction and Mental Health | Early Phase 1 | 2014-10-01 | 2017-01-30 |
NCT00068224 | Autosomal Recessive Polycystic Kidney Disease|Congenital Hepatic Fibrosis|Caroli's Disease|Polycystic Kidney Disease|Joubert Syndrome|Cerebro-Oculo-Renal Syndromes|COACH Syndrome|Senior-Loken Syndrome|Dekaban-Arima Syndrome|Cogan Oculomotor Apraxia|Nephronophthisis|Bardet-Biedl Syndrome|Alstrom Syndrome|Oral-Facial-Digital Syndrome | National Human Genome Research Institute (NHGRI)|National Institutes of Health Clinical Center (CC) | 2003-09-04 | 2017-02-16 | ||
NCT01544309 | Hypercholesterolemia With Concomitant Type 2 Diabetes | Drug: Atorvastatin|Drug: Rosuvastatin | Listen Trial Group | 2012-03-01 | 2015-03-04 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
相关化合物库
使用AMQUAR产品发表文献后请联系我们