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Sofosbuvir

索非布韦,索菲布韦,GS-7977,GS7977,PSI 7977,GS 7977,PSI7977,PSI-7977,

PSI-7977是核苷酸类似物,可用于慢性HCV感染。

目录号
EY1585
EY1585
EY1585
EY1585
EY1585
纯度
99.66%
99.66%
99.66%
99.66%
99.66%
规格
1 mg
5 mg
10 mg
50 mg
100 mg
原价
302
680
930
1320
1820
售价
302
680
930
1320
1820
库存
现货
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Sofosbuvir (PSI-7977, GS-7977) is a HCV NS5B polymerase inhibitor for the treatment of chronic hepatitis C virus (HCV) infection.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    ~100 μM

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Murakami E, et al. J Biol Chem, 2010, 285(45), 34337-34347.

    分子式
    C22H29FN3O9P
    分子量
    529.45
    CAS号
    1190307-88-0
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    100 mg/mL
    Water
    10 mg/mL
    Ethanol
    100 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01994486 Hepatitis C, Chronic Drug: Telaprevir and Sofosbuvir University of Florida|Vertex Pharmaceuticals Incorporated Phase 2 2013-12-01 2015-02-20
    NCT02907996 Hepatitis C Virus Drug: Sofosbuvir Gilead Sciences 2016-09-09 2017-03-16
    NCT02624063 Hepatitis C, Chronic Drug: Daclatasvir + Sofosbuvir|Drug: Simeprevir + Sofosbuvir Federal University of So Paulo Phase 4 2015-12-01 2017-02-17
    NCT02206932 Hepatitis C, Chronic|HIV CDC Category A1 Drug: Sofosbuvir + Simeprevir University of California, San Francisco|Janssen Scientific Affairs, LLC Phase 4 2014-11-21
    NCT03032666 Thalassemia|Hepatitis C Drug: sofosbuvir/velpatasvir Ala'a Sharara|Gilead Sciences|American University of Beirut Medical Center Phase 4 2017-03-25 2017-02-27
    NCT02576314 Chronic Hepatitis C Infection Drug: sofosbuvir and daclatasvir|Drug: ledipasvir/sofosbuvir Humanity & Healthy GI and Liver Centre|Beijing 302 Hospital Phase 3 2015-05-01 2017-01-15
    NCT02783976 HCV Infection Drug: Sovaldi Gilead Sciences 2016-10-28 2017-02-22
    NCT02128542 Hepatitis C Virus Infection Drug: Sofosbuvir|Drug: RBV Gilead Sciences Phase 4 2014-06-01 2016-06-21
    NCT03069001 HCV Drug: Sofosbuvir-Simeprevir|Drug: Sofosbuvir-Ribavirin Ain Shams University Phase 4 2015-06-01 2017-02-27
    NCT01910636 Hepatitis C Drug: Sofosbuvir|Drug: RBV Gilead Sciences Phase 3 2013-02-01 2015-03-13
    NCT02336139 Hepatitis C Drug: Sofosbuvir (SOF)/GS-5816 Kirby Institute Phase 2 2016-03-01 2016-05-15
    NCT02702739 Liver Cirrhosis Drug: Sofosbuvir 400mg/day/Simeprevir 150mg/day /Ribavirin 800mg/day for 12 weeks Azienda Ospedaliera San Camillo Forlanini Phase 4 2015-01-01 2016-03-08
    NCT03063879 Hepatitis C, Chronic|Chronic Renal Failure Drug: Sofosbuvir 400 mg and daclatasvir 60 mg Tehran University of Medical Sciences|Ahvaz Jundishapur University of Medical Sciences|Shiraz University of Medical Sciences|Isfahan University of Medical Sciences|Tabriz University of Medical Sciences Phase 4 2017-03-01 2017-02-23
    NCT02250807 Chronic Hepatitis C|Genotype 4 Chronic Hepatitis C Drug: Simeprevir|Drug: Sofosbuvir Janssen R&D Ireland Phase 3 2015-01-01 2016-09-28
    NCT02125500 Viral Hepatitis C|HIV Drug: Sofosbuvir/Ledipasvir fixed dose French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS) Phase 2 2014-09-01 2016-01-04
    NCT02114151 Hepatitis C Virus Infection Drug: Simeprevir|Drug: Sofosbuvir Janssen Infectious Diseases BVBA Phase 3 2014-04-01 2016-03-07
    NCT02156570 Hepatitis C Drug: Sofosbuvir and ribavirin Kirby Institute Phase 4 2014-10-01 2016-10-19
    NCT02491450 Healthy Drug: Heterosofir|Drug: Sovaldi Genuine Research Center, Egypt|Pharmed Healthcare, Egypt Phase 1 2015-02-01 2015-07-02
    NCT02961426 Hepatitis C Drug: sofosbuvir Drugs for Neglected Diseases|Ministry of Health, Malaysia Phase 2|Phase 3 2016-09-01 2016-11-08
    NCT02074514 Chronic HCV Infection Drug: Sofosbuvir|Drug: RBV Gilead Sciences Phase 3 2014-03-01 2016-09-02
    NCT02551861 Hepatitis C Drug: Daclatasvir|Drug: Sofosbuvir|Drug: Ribavirin Bristol-Myers Squibb Phase 2 2015-12-01 2016-01-14
    NCT02253550 Chronic Hepatitis C Drug: Simeprevir|Drug: Sofosbuvir Peter J. Ruane, M.D.|Janssen Scientific Affairs, LLC|Peter J. Ruane, M.D., Inc. Phase 2 2014-10-01 2016-02-22
    NCT03057847 Hepatitis C, Chronic|Opioid-use Disorder Drug: Sofosbuvir/Velpatasvir University of Pittsburgh Phase 4 2017-07-01 2017-02-15
    NCT02804386 Hepatitis C, Chronic Drug: Sofosbuvir PharmEvo Pvt Ltd Phase 4 2016-06-01 2016-07-25

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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