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Mianserin HCl

盐酸米安色林,盐酸米安舍林,盐酸甲苯比卓,盐酸咪色林,盐酸米噻林,盐酸脱尔烦,ORG GB-94 HCl

Mianserin盐酸盐是H1受体反向激动剂，有抗抑郁活性。

目录号
EY1580
EY1580
纯度
99.55%
99.55%
规格
100 mg
500 mg
原价
988_
2,498_
售价
988_
2,498_
库存
现货
现货
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  • 生物活性

    Mianserin is an potent antagonist of H1 histamine receptor and 5-HT serotonin receptors, used for the treatment of depression.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] de Boer TH, et al. J Pharmacol Exp Ther,?996, 277(2), 852-860.

    分子式
    C18H21ClN2    		 分子量
    300.83    		 CAS号
    21535-47-7    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    60 mg/mL    		 Water
    20 mg/mL    		 Ethanol
    14 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02761161 Post Traumatic Stress Disorder|Depression Drug: Mianserin|Behavioral: Imagery Rehearsal Therapy Mental Health Services in the Capital Region, Denmark|Danish Center for Sleep Medicine Phase 4 2016-03-01 2016-05-02
    NCT00865696 Healthy Drug: Mirtazapine 15 mg tablets, single dose|Drug: REMERON 15 mg tablets, single dose Actavis Inc. Phase 1 2001-09-01 2010-08-13
    NCT00865384 Healthy Drug: Mirtazapine 15 mg tablets, single dose|Drug: REMERON 15 mg tablets, single dose Actavis Inc. Phase 1 2001-09-01 2010-08-13
    NCT02650544 Carcinoma, Non-Small-Cell Lung|Depression Drug: Mirtazapine|Drug: Placebo Sun Yat-sen University Phase 2 2015-12-01 2016-01-06
    NCT02646449 Major Depressive Disorder|Alcohol Use Disorder Drug: Mirtazapine|Drug: Placebo University of Pittsburgh Phase 2 2015-06-01 2016-01-04
    NCT02228239 Healthy Drug: Esketamine|Drug: Mirtazapine|Drug: Placebo (Matched to Esketamine)|Drug: Placebo (Matched to Mirtazapine) Janssen Research & Development, LLC Phase 1 2014-09-01 2014-12-29
    NCT02185131 Major Depressive Disorder|Alcohol Use Disorder Drug: Mirtazapine|Drug: Placebo University of Pittsburgh|National Institute on Alcohol Abuse and Alcoholism (NIAAA) Phase 2 2013-09-01 2016-01-07
    NCT01867775 Alzheimer's Disease|Sleep Disorders Drug: Mirtazapine Brasilia University Hospital Phase 3 2012-05-01 2013-06-03
    NCT01601002 Major Depressive Disorder Drug: Mirtazapine Lawson Health Research Institute Phase 4 2012-06-01 2016-04-20
    NCT01505504 Alzheimer's Disease|Weight Loss|Mixed Dementia|Dementia Drug: mirtazapine Brugmann University Hospital 2004-01-01 2012-01-05
    NCT01240096 Functional Dyspepsia Drug: Mirtazapine Universitaire Ziekenhuizen Leuven Phase 4 2006-09-01 2010-11-12
    NCT01119924 Depression|Pain Drug: Smilon|Drug: Placebo Nang Kuang Pharmaceutical Co., Ltd.|Buddhist Tzu Chi General Hospital Phase 4 2009-12-01 2011-06-07
    NCT01039740 Depression Drug: Mirtazapine Samsung Medical Center 2003-02-01 2015-12-30
    NCT00960830 Depression|Anxiety Drug: mirtazapine|Drug: mirtazapine Universidad Nacional de Rosario 2007-04-01 2009-08-17
    NCT00919295 Fibromyalgia Syndrome Drug: mirtazapine|Drug: placebo Mahidol University|University of Texas|University of Wuerzburg Phase 2 2008-12-01 2012-07-24
    NCT00878540 Healthy Drug: mirtazapine Max-Planck-Institute of Psychiatry Phase 1 2008-09-01 2010-09-15
    NCT00835575 Healthy Drug: Mirtazapine 15 mg (Orally Disintegrating) Tablets|Drug: REMERON SolTab 15 mg Orally Disintegrating Tablets Teva Pharmaceuticals USA Phase 1 2003-07-01 2009-09-01
    NCT00834197 Healthy Drug: Mirtazapine 15 mg (Orally Disintegrating) Tablets|Drug: REMERON SolTab 15 mg Orally Disintegrating Tablets Teva Pharmaceuticals USA Phase 1 2003-07-01 2009-09-01
    NCT00832520 Advanced Cancer Drug: Remeron (mirtazapine) New Mexico Cancer Care Alliance Phase 2 2008-11-01 2015-06-16
    NCT00488072 Advanced Cancer|Anorexia|Weight Loss|Insomnia Drug: Mirtazapine|Drug: Placebo M.D. Anderson Cancer Center 2007-01-01 2016-07-27
    NCT00449189 PTSD Drug: Mirtazapine|Drug: Placebo Tuscaloosa Research & Education Advancement Corporation Phase 4 2006-10-01 2012-08-30
    NCT00302107 Anxiety|PTSD Drug: Mirtazapine|Drug: Placebo VA Office of Research and Development Phase 4 2006-04-01 2014-11-25
    NCT00288782 Mental Disorders|Mood Disorders|Affective Disorders|Depressive Disorders Drug: Mirtazapine University of Aarhus|The Danish Medical Research Council|Fund for Advancement of Medical Science|Max Woerzner's Research Award Phase 4 2006-02-01 2007-04-18
    NCT02374567 Dementia|Depression|Schizophrenia|Psychosomatic Disorders|Anxiety Disorders Drug: Phenobarbital|Drug: Phenytoin|Drug: Carbamazepine|Drug: Oxcarbazepine|Drug: Valproic Acid|Drug: Lamotrigine|Drug: Topiramate|Drug: Gabapentin|Drug: Levetiracetam|Drug: Pregabalin|Drug: Lacosamide|Drug: Clonazepam|Drug: Biperiden|Drug: Levomepromazine|Drug: Fluphenazine|Drug: Perphenazine|Drug: Perazine|Drug: Thioridazine|Drug: Haloperidol|Drug: Melperone|Drug: Pipamperone|Drug: Bromperidol|Drug: Benperidol|Drug: Sertindole|Drug: Ziprasidone|Drug: Flupentixol|Drug: Chlorprothixene|Drug: Zuclopenthixol|Drug: Fluspirilene|Drug: Pimozide|Drug: Clozapine|Drug: Olanzapine|Drug: Quetiapine|Drug: Sulpiride|Drug: Tiapride|Drug: Amisulpride|Drug: Prothipendyl|Drug: Risperidone|Drug: Aripiprazole|Drug: Paliperidone|Drug: Diazepam|Drug: Oxazepam|Drug: Lorazepam|Drug: Bromazepam|Drug: Clobazam|Drug: Alprazolam|Drug: Hydroxyzine|Drug: Buspirone|Drug: Chloral Hydrate|Drug: Flurazepam|Drug: Nitrazepam|Drug: Triazolam|Drug: Lormetazepam|Drug: Temazepam|Drug: Midazolam|Drug: Brotizolam|Drug: Zopiclone|Drug: Zolpidem|Drug: Zaleplon|Drug: Melatonin|Drug: Clomethiazole|Drug: Diphenhydramine|Drug: Promethazine|Drug: Imipramine|Drug: Clomipramine|Drug: Opipramol|Drug: Trimipramine|Drug: Amitriptyline|Drug: Nortriptyline|Drug: Doxepin|Drug: Maprotiline|Drug: Amitriptyline oxide|Drug: Fluoxetine|Drug: Citalopram|Drug: Paroxetine|Drug: Sertraline|Drug: Fluvoxamine|Drug: Escitalopram|Drug: Tranylcypromine|Drug: Moclobemide|Drug: Mianserin|Drug: Trazodone|Drug: Mirtazapine|Drug: Bupropion|Drug: Venlafaxine|Drug: Reboxetine|Drug: Duloxetine|Drug: Agomelatine|Drug: Pyritinol|Drug: Piracetam|Drug: Donepezil|Drug: Rivastigmine|Drug: Galantamine|Drug: Memantine|Drug: Nicergoline|Drug: Acamprosate|Drug: Lithium Hannover Medical School Phase 3 2015-01-01 2017-02-23
    NCT01305707 Depression Device: C-ECT|Drug: PHARMACOTHERAPY Hospital Universitari de Bellvitge Phase 4 2009-07-01 2015-08-28

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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