Home > DPP4 & > Vildagliptin

Vildagliptin

维达列汀,LAF237,Galvus,NVP-LAF 237,Zomelis,LAF-237,LAF 237,LAF237

Vildagliptin (LAF-237)抑制DPP−4，IC50为2.3 nM。

目录号
EY1569
EY1569
EY1569
EY1569
纯度
99.49%
99.49%
99.49%
99.49%
规格
5 mg
10 mg
50 mg
100 mg
原价
360
586
1180
1620
售价
360
586
1180
1620
库存
现货
现货
现货
现货
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  • 生物活性

    Vildagliptin (LAF-237) inhibits DPP−4 with IC50 of 2.3 nM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

    10 μmol/kg单剂量口服给药

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Villhauer EB, et al. J Med Chem, 2003, 46(13), 2774-2789.

    分子式
    C17H25N3O2    		 分子量
    303.41    		 CAS号
    274901-16-5    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    60 mg/mL    		 Water
    60 mg/mL    		 Ethanol
    60 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01882907 Type 2 Diabetes Drug: vildagliptin|Drug: Pioglitazone Pusan National University Hospital Phase 4 2009-12-01 2015-03-04
    NCT01686932 Diabetes Mellitus Type 2 Drug: Vildagliptin|Drug: Sitagliptin Novartis Pharmaceuticals|Novartis Phase 4 2012-11-01 2016-02-02
    NCT01582243 Diabetes Mellitus, Type 2 Drug: Vildagliptin Novartis Pharmaceuticals|Novartis Phase 4 2013-04-01 2016-09-15
    NCT01541956 Type 2 Diabetes Drug: Metformin|Drug: vildagliptin Novartis Pharmaceuticals|Novartis Phase 4 2012-02-01 2016-11-16
    NCT01147276 Diabetes|Hypoglycemia Drug: Vildagliptin Lund University Phase 4 2010-09-01 2012-09-21
    NCT00980356 Diabetes Mellitus Drug: Vildagliptin Medical University of Vienna Phase 2 2009-09-01 2013-04-04
    NCT01827280 1- Microvascular Function|2-oxidative Stress|3-inflammation Drug: Vildagliptin Rio de Janeiro State University|Laboratory for Clinical and Experimental Research on Vascular Biology Phase 4 2013-04-01 2013-04-04
    NCT01426802 Type 2 Diabetes Mellitus Drug: vildagliptin Novartis Pharmaceuticals|Novartis Phase 4 2010-10-01 2017-02-23
    NCT02145611 Type 2 Diabetes Mellitus|Hypertension|Endothelial Dysfunction Drug: Glibenclamide|Drug: Vildagliptin Dr. Jos Fernando Vilela-Martin MD PhD|Novartis|Hospital de Base Phase 4 2013-07-01 2016-08-15
    NCT01219400 Diabetes Drug: Vildagliptin Lund University Phase 4 2012-01-01 2014-09-29
    NCT00936234 SDF-1 is an Important Cytokine for Neovascularization. Cleavage of SDF-1 is Reduced by DPPIV Inhibitors Drug: Vildagliptin Johann Wolfgang Goethe University Hospital Phase 2|Phase 3 2009-07-01 2011-06-21
    NCT00633997 Diabetes Mellitus, Type 2 Drug: Vildagliptin|Drug: Vildagliptin Novartis Phase 1|Phase 2 2008-02-01 2016-04-25
    NCT01582230 Type 2 Diabetes Mellitus Drug: Vildagliptin|Drug: Placebo Novartis Pharmaceuticals|Novartis Phase 3 2012-04-01 2013-08-29
    NCT01257451 Type 2 Diabetes Mellitus Drug: Vildagliptin|Drug: Placebo Novartis Pharmaceuticals|Novartis Phase 3 2010-12-01 2012-12-14
    NCT00380445 Diabetes Mellitus, Type 2 Drug: Vildagliptin Novartis Phase 3 2006-01-01 2017-02-20
    NCT01497522 Diabetes Mellitus, Type 2 Drug: Vildagliptin|Drug: Placebo Novartis Pharmaceuticals|Novartis Phase 3 2011-12-01 2017-02-23
    NCT00099853 Diabetes Mellitus, Type 2 Drug: Vildagliptin|Drug: pioglitazone|Drug: Placebo Novartis Pharmaceuticals|Novartis Phase 3 2004-05-01 2013-01-02
    NCT01398592 Diabetes Mellitus Type 2 Drug: Vildagliptin|Drug: Sitagliptin Novartis Pharmaceuticals|Novartis Phase 4 2011-06-01 2013-02-11
    NCT01099137 Diabetes Drug: Vildagliptin|Drug: Sulphonylurea dose-up Seoul National University Bundang Hospital Phase 4 2010-01-01 2014-05-26
    NCT01559025 Type 1 Diabetes|Insulin Dependent Diabetes|Juvenile Onset Diabetes Mellitus|Autoimmune Diabetes Drug: Vildagliptin Federal University of So Paulo|Novartis Phase 3 2014-03-01 2014-05-13
    NCT00138554 Diabetes Mellitus, Type 2 Drug: vildagliptin|Drug: pioglitazone Novartis Phase 3 2004-11-01 2017-02-21
    NCT01766778 Type-2 Diabetes Mellitus Drug: Vildagliptin|Drug: Metformin Novartis Pharmaceuticals|Novartis Phase 4 2013-05-01 2016-02-23
    NCT00101712 Diabetes Mellitus, Type 2 Drug: vildagliptin|Drug: Vildagliptin Placebo Novartis Pharmaceuticals|Novartis Phase 3 2004-10-01 2012-05-04
    NCT02475070 Type 2 Diabetes Drug: Vildagliptin|Drug: Dapagliflozin Lund University Phase 4 2016-01-01 2017-02-25
    NCT00894868 Congestive Heart Failure|Type II Diabetes Mellitus Drug: vildagliptin|Drug: placebo of vildagliptin Novartis Pharmaceuticals|Novartis Phase 4 2009-05-01 2014-04-24

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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