Flumazenil(Ro 15-1788)是非选择性含α1,α2,α3和α5 GABAA受体拮抗剂。
Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Hoffman EJ, et al. Clin Pharm, 1993, 12(9), 641-656.
分子式 C15H14FN3O3 |
分子量 303.29 |
CAS号 78755-81-4 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 5 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02048969 | Hepatic Encephalopathy|Liver Cirrhosis | Drug: Flumazenil|Drug: Placebo | Yale University | Phase 1|Phase 2 | 2014-06-01 | 2016-04-13 |
NCT01183312 | Hypersomnia|Primary Hypersomnia|Idiopathic Hypersomnia|Narcolepsy Without Cataplexy | Drug: Flumazenil | Lynn Marie Trotti|Georgia Research Alliance|Emory University | Phase 1|Phase 2 | 2010-09-01 | 2013-11-13 |
NCT01071889 | Healthy | Drug: Flumazenil|Drug: Placebo | Coeruleus Ltd. | Phase 1|Phase 2 | 2010-05-01 | 2015-01-29 |
NCT02157428 | Adverse Effect of Other General Anesthetics | Drug: Flumazenil|Drug: saline | University of Sao Paulo | 2011-01-01 | 2014-06-05 | |
NCT00997087 | Obsessive Compulsive Disorder | Drug: Flumazenil | Parkway Medical Center | Phase 2 | 2009-10-01 | 2014-04-18 |
NCT02899156 | Delirium | Drug: Flumazenil|Drug: Placebo | University of California, Davis | Phase 4 | 2016-03-01 | 2016-09-08 |
NCT00695630 | Dental Anxiety | Drug: Flumazenil|Drug: Placebo | University of Washington|National Institutes of Health (NIH) | Phase 1|Phase 2 | 2006-09-01 | 2008-06-11 |
NCT01904487 | Alcoholism | Radiation: [11C]flumazenil|Drug: Tiagabine | Rajesh Narendran|University of Pittsburgh | Phase 1 | 2011-04-01 | 2014-01-27 |
NCT00000246 | Substance-Related Disorders | Drug: Flumazenil | Yale University|National Institute on Drug Abuse (NIDA) | Phase 2 | 1993-01-01 | 2016-09-06 |
NCT01655914 | Insomnia | Drug: Flumazenil | Coeruleus Ltd. | Phase 1 | 2010-07-01 | 2015-01-29 |
NCT02690389 | Acupuncture|General Anaesthesia|Sedation | Drug: Flumazenil|Procedure: Acupuncture | Dr. Yin Liu|Sichuan Cancer Hospital and Research Institute | 2015-01-01 | 2016-02-18 | |
NCT00681746 | Anxiety | Drug: AZD6280|Drug: (11C) flumazenil | AstraZeneca | Phase 1 | 2008-02-01 | 2010-12-08 |
NCT00681720 | Anxiety | Drug: AZD7325|Drug: Radioligand (11C) flumazenil | AstraZeneca | Phase 1 | 2008-02-01 | 2008-08-20 |
NCT01651520 | Multiple Sclerosis | Drug: PET with 11C-Flumazenil | Assistance Publique - Hpitaux de Paris | 2013-03-01 | 2016-05-20 | |
NCT00015678 | Stroke|Healthy | National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) | 2001-04-01 | 2008-03-03 | ||
NCT00262639 | Alcohol Dependence | Drug: Flumazenil and Gabapentin|Drug: Placebo | Medical University of South Carolina | Phase 2|Phase 3 | 2005-12-01 | 2009-12-09 |
NCT01547819 | Posttraumatic Stress Disorder|Traumatic Brain Injury | National Institutes of Health Clinical Center (CC)|Uniformed Services University of the Health Sciences | 2012-02-16 | 2017-01-24 | ||
NCT00570388 | Alcohol Dependence | Drug: Prometa Treatment Program | Institute of Addiction Medicine | 2007-03-01 | 2008-01-15 | |
NCT01819675 | Stroke|Hemiplegia | Device: Low frequency rTMS|Device: High frequency rTMS|Device: Sham rTMS | Seoul National University Bundang Hospital|Ministry of Health & Welfare, Korea | 2013-03-01 | 2016-02-26 | |
NCT00034398 | Tourette Syndrome | National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) | 2002-04-24 | 2017-01-24 | ||
NCT00306865 | Focal Dystonia | National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) | 2006-03-17 | 2017-01-24 | ||
NCT02138500 | Healthy | Drug: PF-06372865|Drug: PF-06372865|Drug: PF-06372865 | Pfizer | Phase 1 | 2014-05-01 | 2014-09-23 |
NCT02696512 | Brain Injury | Drug: Polypharmacy using FDA-approved products|Device: Median Nerve Stimulation (MNS)|Dietary Supplement: Nutraceutical Supplementation|Other: Standard of Care | International Brain Research Foundation | Phase 1|Phase 2 | 2016-03-01 | 2016-08-31 |
NCT00931619 | Epilepsy|Epilepsy, Temporal Lobe|Depression|Depressive Disorder, Major | National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) | 2009-06-29 | 2017-01-24 | ||
NCT02439164 | Glioma | Drug: Midazolam|Drug: propofol|Drug: Dexmedetomidine | Beijing Tiantan Hospital | 2015-07-01 | 2016-04-25 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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