Flumazenil

氟马西尼,氟马泽尼,RO 15-1788

Flumazenil(Ro 15-1788)是非选择性含α1,α2,α3和α5 GABAA受体拮抗剂。

目录号
EY1568
EY1568
EY1568
EY1568
纯度
99.35%
99.35%
99.35%
99.35%
规格
5 mg
10 mg
50 mg
100 mg
原价
340
530
1265
1760
售价
340
530
1265
1760
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Flumazenil is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Hoffman EJ, et al. Clin Pharm, 1993, 12(9), 641-656.

    分子式
    C15H14FN3O3
    分子量
    303.29
    CAS号
    78755-81-4
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    5 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02048969 Hepatic Encephalopathy|Liver Cirrhosis Drug: Flumazenil|Drug: Placebo Yale University Phase 1|Phase 2 2014-06-01 2016-04-13
    NCT01183312 Hypersomnia|Primary Hypersomnia|Idiopathic Hypersomnia|Narcolepsy Without Cataplexy Drug: Flumazenil Lynn Marie Trotti|Georgia Research Alliance|Emory University Phase 1|Phase 2 2010-09-01 2013-11-13
    NCT01071889 Healthy Drug: Flumazenil|Drug: Placebo Coeruleus Ltd. Phase 1|Phase 2 2010-05-01 2015-01-29
    NCT02157428 Adverse Effect of Other General Anesthetics Drug: Flumazenil|Drug: saline University of Sao Paulo 2011-01-01 2014-06-05
    NCT00997087 Obsessive Compulsive Disorder Drug: Flumazenil Parkway Medical Center Phase 2 2009-10-01 2014-04-18
    NCT02899156 Delirium Drug: Flumazenil|Drug: Placebo University of California, Davis Phase 4 2016-03-01 2016-09-08
    NCT00695630 Dental Anxiety Drug: Flumazenil|Drug: Placebo University of Washington|National Institutes of Health (NIH) Phase 1|Phase 2 2006-09-01 2008-06-11
    NCT01904487 Alcoholism Radiation: [11C]flumazenil|Drug: Tiagabine Rajesh Narendran|University of Pittsburgh Phase 1 2011-04-01 2014-01-27
    NCT00000246 Substance-Related Disorders Drug: Flumazenil Yale University|National Institute on Drug Abuse (NIDA) Phase 2 1993-01-01 2016-09-06
    NCT01655914 Insomnia Drug: Flumazenil Coeruleus Ltd. Phase 1 2010-07-01 2015-01-29
    NCT02690389 Acupuncture|General Anaesthesia|Sedation Drug: Flumazenil|Procedure: Acupuncture Dr. Yin Liu|Sichuan Cancer Hospital and Research Institute 2015-01-01 2016-02-18
    NCT00681746 Anxiety Drug: AZD6280|Drug: (11C) flumazenil AstraZeneca Phase 1 2008-02-01 2010-12-08
    NCT00681720 Anxiety Drug: AZD7325|Drug: Radioligand (11C) flumazenil AstraZeneca Phase 1 2008-02-01 2008-08-20
    NCT01651520 Multiple Sclerosis Drug: PET with 11C-Flumazenil Assistance Publique - Hpitaux de Paris 2013-03-01 2016-05-20
    NCT00015678 Stroke|Healthy National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) 2001-04-01 2008-03-03
    NCT00262639 Alcohol Dependence Drug: Flumazenil and Gabapentin|Drug: Placebo Medical University of South Carolina Phase 2|Phase 3 2005-12-01 2009-12-09
    NCT01547819 Posttraumatic Stress Disorder|Traumatic Brain Injury National Institutes of Health Clinical Center (CC)|Uniformed Services University of the Health Sciences 2012-02-16 2017-01-24
    NCT00570388 Alcohol Dependence Drug: Prometa Treatment Program Institute of Addiction Medicine 2007-03-01 2008-01-15
    NCT01819675 Stroke|Hemiplegia Device: Low frequency rTMS|Device: High frequency rTMS|Device: Sham rTMS Seoul National University Bundang Hospital|Ministry of Health & Welfare, Korea 2013-03-01 2016-02-26
    NCT00034398 Tourette Syndrome National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) 2002-04-24 2017-01-24
    NCT00306865 Focal Dystonia National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) 2006-03-17 2017-01-24
    NCT02138500 Healthy Drug: PF-06372865|Drug: PF-06372865|Drug: PF-06372865 Pfizer Phase 1 2014-05-01 2014-09-23
    NCT02696512 Brain Injury Drug: Polypharmacy using FDA-approved products|Device: Median Nerve Stimulation (MNS)|Dietary Supplement: Nutraceutical Supplementation|Other: Standard of Care International Brain Research Foundation Phase 1|Phase 2 2016-03-01 2016-08-31
    NCT00931619 Epilepsy|Epilepsy, Temporal Lobe|Depression|Depressive Disorder, Major National Institute of Neurological Disorders and Stroke (NINDS)|National Institutes of Health Clinical Center (CC) 2009-06-29 2017-01-24
    NCT02439164 Glioma Drug: Midazolam|Drug: propofol|Drug: Dexmedetomidine Beijing Tiantan Hospital 2015-07-01 2016-04-25

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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