Progesterone is a critical hormone for the maintenance of pregnancy, menstrual cycle, endometrium and functions with its receptor.
Progesterone is an endogenous steroid hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Owen GI, et al. J Biol Chem,1998, 273(17), 10696-10701.
分子式 C21H30O2 |
分子量 314.47 |
CAS号 57-83-0 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 23 mg/mL |
Water <1 mg/mL |
Ethanol 60 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01940653 | Progesterone Supplementation | Drug: Progesterone | Universitair Ziekenhuis Brussel | Phase 4 | 2012-11-01 | 2014-05-20 |
NCT02304237 | Premature Birth | Drug: Vaginal progesterone|Drug: Intramuscular progesterone | Ewha Womans University Mokdong Hospital|Samsung Medical Center|Han Wha Pharma Co., Ltd.|Ministry of Health & Welfare, Korea | Phase 3 | 2014-12-01 | 2014-11-26 |
NCT01180296 | Preterm Birth | Drug: oral micronized progesterone|Drug: Identical Placebo tablet | Fetal Medicine Foundation | Phase 3 | 2006-11-01 | 2012-03-02 |
NCT02779582 | Perimenopause|Menstrual Cramps | Drug: Oral Micronized Progesterone|Drug: Placebo | University of British Columbia | Phase 3 | 2015-06-01 | 2016-11-09 |
NCT00218257 | Cocaine Abuse|Cocaine-Related Disorders | Drug: Progesterone|Other: placebo | University of Minnesota - Clinical and Translational Science Institute|National Institute on Drug Abuse (NIDA) | 2002-07-01 | 2015-11-16 | |
NCT01959464 | Infertility|Pregnancy | Drug: Crinone vaginal progesterone gel|Drug: Placebo vaginal gel | Carolinas Healthcare System|Carolinas Medical Center | Phase 4 | 2008-11-01 | 2014-08-04 |
NCT01406197 | Preterm Labor | Drug: Experimental: Vaginal progesterone|Drug: Experimental: Topical progesterone|Drug: Experimental: Intramuscular progesterone | St. Joseph's Hospital and Medical Center, Phoenix | 2011-07-01 | 2016-10-10 | |
NCT01954966 | Nicotine Dependence|Nicotine Withdrawal | Drug: Progesterone|Drug: Placebo | University of Pennsylvania|National Institute on Drug Abuse (NIDA) | Phase 4 | 2010-11-01 | 2017-03-20 |
NCT02772120 | Infertility | Drug: Vaginal progesterone gel (Crinone8%)|Drug: Intramuscular Progesterone | Brigham and Women's Hospital | Phase 4 | 2016-05-01 | 2016-05-11 |
NCT02338830 | Premature Labour | Drug: Progesterone | Mohamed Sayed Abdelhafez|Mansoura University | Phase 4 | 2012-06-01 | 2015-01-13 |
NCT02913495 | Premature Birth | Drug: Vaginal Progesterone|Drug: Intramuscular Progesterone | Thomas Jefferson University|Baystate Medical Center|George Washington University | Phase 4 | 2016-09-01 | 2016-12-20 |
NCT01081652 | Infertility | Drug: Micronised Progesterone|Drug: Progesterone | Merck KGaA | Phase 3 | 2004-05-01 | 2014-07-30 |
NCT01057511 | Postmenopausal Endometrium | Drug: Crinone 8%|Drug: Progesterone | Peking Union Medical College Hospital|Merck Serono International SA | Phase 1|Phase 2 | 2009-12-01 | 2012-04-01 |
NCT00919919 | Endometrial Hyperplasia|Endometrial Cancer | Drug: progesterone|Drug: activella | Rabin Medical Center|Ferring Pharmaceuticals | Phase 2 | 2009-06-01 | 2009-06-11 |
NCT01249274 | Cocaine Abuse|Cocaine Dependence | Drug: Progesterone|Other: Placebo | Yale University|National Institute on Drug Abuse (NIDA) | 2010-08-01 | 2016-10-19 | |
NCT03058536 | Preterm Birth|Twin Pregnancy With Antenatal Problem | Device: Arabin Pessary|Drug: Vaginal Progesterone|Other: Arabin Pessary and Progesterone | Mario Henrique Burlacchini de Carvalho|University of Sao Paulo | Phase 2|Phase 3 | 2017-02-21 | 2017-03-13 |
NCT00579553 | Infant, Premature|Premature Birth | Drug: Intramuscular Progesterone|Drug: Vaginal Progesterone | University of Oklahoma | 2006-10-01 | 2014-05-20 | |
NCT01177904 | All Patients Which Show a Gestational Sac in Their Uterus in the First US Are Included in This Study and Randomized. | Other: Cease progsterone at 5|Other: control group: progesterone 8 | Instituto Valenciano de Infertilidad, IVI VALENCIA | Phase 4 | 2009-01-01 | 2011-03-16 |
NCT00536003 | Preterm Delivery|Morbidity|Perinatal Mortality | Drug: progesterone|Drug: placebo | begoa Martinez de Tejada|Centre Hospitalier Universitaire Vaudois|University Hospital Inselspital, Berne|Basel Women University Hospital|University of Zurich|Kantonsspital Graubuenden|Cantonal Hospital of St. Gallen|Luzerner Kantonsspital|Kantonsspital Winterthur KSW|Besins Laboratory, Belgium|Hospital Bernardino Rivadavia Buenos Aires|Hospital Carlos G. Durand Buenos Aires|CEMIC Buenos Aires|Hospital Donacin Francisco Santojanni Buenos Aires|Hospital Dr. Cosme Argerich Buenos Aires|Hospital Dr. T. Alvarez Buenos Aires|Hospital Italiano de Buenos Aires|Hospital J. M. Penna Buenos Aires|Hospital Materno Infantil Ramn Sard Buenos Aires|Hospital Interzonal Alberto Antranik Eurnekian, provincia Buenos Aires|Hospital Municipal Materno Infantil Comodoro Hugo Cesar Meisner, provincia Buenos Aires|Hospital Comunal de Tigre, provincia Buenos Aires|Hospital Dr. Arturo Oativia, provincia Buenos Aires|Hospital Dr. Carlos Bocalandro, provincia Buenos Aires|Hospital Hroes de Malvinas, provincia Buenos Aires|Hospital Provincial Magdalena V. de Martnez|Hospital Mariano y Luciano de la Vega, provincia Buenos Aires|Hospital Municipal Ostaciana B. de Lavignolle, provincia Buenos Aires|Hospital Materno Infantil de San Isidro, provincia Buenos Aires|Hospital Virgen del Carmen, provincia Buenos Aires|Hospital J. B. Iturraspe, Santa Fe|Hospital Maternidad Nuestra Seora De Las Mercedes, Tucumn|Hospital Materno Infantil San Roque, Entre Ros|Hospital Villa Dolores, Crdoba|University Hospital, Geneva | Phase 3 | 2006-07-01 | 2012-06-05 |
NCT01602679 | Female Reproductive Physiology | Drug: oral micronized progesterone suspension|Drug: Placebo | University of Virginia|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Phase 1 | 2012-05-01 | 2017-02-23 |
NCT02254577 | Infertility | Drug: Endometrinplus Progesterone in Oil (PIO)|Drug: Progesterone in Oil (PIO) Only | Shady Grove Fertility Reproductive Science Center|Ferring Pharmaceuticals | Phase 4 | 2014-10-01 | 2016-08-30 |
NCT02400021 | HIV-1 Infection | Drug: Prometrium | Mount Sinai Hospital, Canada|CIHR Canadian HIV Trials Network | Phase 2 | 2015-08-01 | 2015-07-28 |
NCT01523483 | Preterm Birth | Drug: Progesterone|Drug: placebo vaginal capsules | University Medical Centre Ljubljana|Slovenian Research Agency | 2012-03-01 | 2015-04-21 | |
NCT01286246 | Obstetric Labor, Premature | Drug: Vaginal progesterone|Drug: Placebo | University of Calgary | Phase 4 | 2011-01-01 | 2015-01-07 |
NCT00929006 | Puberty|Hyperandrogenism | Drug: Micronized progesterone suspension|Drug: Placebo | University of Virginia|National Institutes of Health (NIH) | Phase 1 | 2008-06-01 | 2017-02-23 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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