Abacavir sulfate是一种常用的核苷类似物,具有抗HIV-1病毒活性。Abacavir是一种鸟嘌呤类似物,它的靶点是病毒的反转录酶。
Abacavir is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Mallal S, et al. Lancet, 2002, 359(9308), 727-732.
分子式 C28H38N12O6S |
分子量 670.74 |
CAS号 188062-50-2 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO <1 mg/mL |
Water 77 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01205243 | Infection, Human Immunodeficiency Virus I | Drug: ZIAGEN | ViiV Healthcare|GlaxoSmithKline | 2010-11-01 | 2015-09-21 | |
NCT02101216 | Psoriasis | Drug: Prurisol|Drug: Ziagen | Cellceutix Corporation | Phase 1 | 2014-03-01 | 2015-03-02 |
NCT01886638 | HIV|Cardiovascular Disease | Drug: Abacavir | Bayside Health | Phase 4 | 2013-08-01 | 2015-05-21 |
NCT01973439 | HIV Infection | Other: Intervention 1: PK assessment while on Twice Daily Abacavir|Other: Intervention 2: PK assessment while on Once Daily Abacavir | PENTA Foundation | Phase 1 | 2006-07-01 | 2014-02-03 |
NCT00765271 | HIV | Drug: Abacavir|Drug: Darunavir/ritonavir|Drug: Raltegravir | St Stephens Aids Trust | Phase 1 | 2008-05-01 | 2009-11-17 |
NCT01220232 | Healthy Volunteers | Drug: Abacavir/Lamivudine|Drug: Abacavir/Lamivudine|Drug: Lersivirine | Pfizer|ViiV Healthcare | Phase 1 | 2010-11-01 | 2011-02-03 |
NCT02093585 | HIV | Drug: abacavir (600 mg QD)|Drug: tenofovir (245 mg QD) | Jan Gerstoft|Rigshospitalet, Denmark | Phase 4 | 2014-01-01 | 2015-12-11 |
NCT01153217 | HIV | Drug: Switch from tenofovir to abacavir | Germans Trias i Pujol Hospital | Phase 3 | 2010-07-01 | 2012-10-16 |
NCT00002141 | HIV Infections | Drug: Abacavir sulfate | Burroughs Wellcome|NIH AIDS Clinical Trials Information Service | Phase 1 | 1994-07-01 | 2005-06-23 |
NCT00002197 | HIV Infections | Drug: Abacavir sulfate | Glaxo Wellcome|NIH AIDS Clinical Trials Information Service | 2005-06-23 | ||
NCT00002200 | HIV Infections | Drug: Abacavir sulfate | Glaxo Wellcome|NIH AIDS Clinical Trials Information Service | 2005-06-23 | ||
NCT00002163 | AIDS Dementia Complex|HIV Infections | Drug: Abacavir sulfate | Glaxo Wellcome|NIH AIDS Clinical Trials Information Service | Phase 3 | 2005-06-23 | |
NCT00002198 | HIV Infections | Drug: Abacavir sulfate | Glaxo Wellcome|NIH AIDS Clinical Trials Information Service | Phase 1 | 2005-06-23 | |
NCT00011479 | HIV Infections | Drug: Abacavir sulfate | National Institute of Allergy and Infectious Diseases (NIAID)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Phase 1 | 2012-05-17 | |
NCT00002388 | HIV Infections | Drug: Abacavir sulfate | Glaxo Wellcome|NIH AIDS Clinical Trials Information Service | Phase 1 | 2005-06-23 | |
NCT01052701 | Hepatitis C | Other: Ribavrin|Drug: Abacavir plus Ribavirin | Johns Hopkins University|GlaxoSmithKline|University of Nebraska | Phase 1 | 2009-12-01 | 2011-06-22 |
NCT01656122 | HIV | Drug: abacavir|Drug: 3TC | The HIV Netherlands Australia Thailand Research Collaboration|Radboud University|amfAR, The Foundation for AIDS Research|PHPT/AMS Laboratory, Faculty of Associated Medical Sciences, Chiang Mai University|Chulalongkorn University|ViiV Healthcare | Phase 2|Phase 3 | 2012-07-01 | 2016-02-18 |
NCT00002390 | HIV Infections | Drug: Abacavir sulfate | Glaxo Wellcome|NIH AIDS Clinical Trials Information Service | Phase 2 | 2005-06-23 | |
NCT00314626 | HIV Infections | Drug: efavirenz|Drug: Abacavir+lamivudine | Germans Trias i Pujol Hospital|Fundacio Lluita Contra la SIDA | Phase 3 | 2004-11-01 | 2008-01-25 |
NCT00002364 | HIV Infections | Drug: Abacavir sulfate | Glaxo Wellcome|NIH AIDS Clinical Trials Information Service | Phase 2 | 2005-06-23 | |
NCT02509195 | HIV | Drug: Triumeq | St Stephens Aids Trust|ViiV Healthcare | Phase 4 | 2015-07-01 | 2017-03-16 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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