Home > HIV Protease & HIV & > Abacavir sulfate

Abacavir sulfate

硫酸阿巴卡韦,1592U89

Abacavir sulfate是一种常用的核苷类似物,具有抗HIV-1病毒活性。Abacavir是一种鸟嘌呤类似物,它的靶点是病毒的反转录酶。

目录号
EY1551
EY1551
EY1551
纯度
99.71%
99.71%
99.71%
规格
5 mg
10 mg
50 mg
原价
302
486
1060
售价
302
486
1060
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Abacavir is a commonly used nucleoside analogue with potent antiviral activity against HIV-1.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Mallal S, et al. Lancet, 2002, 359(9308), 727-732.

    分子式
    C28H38N12O6S
    分子量
    670.74
    CAS号
    188062-50-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    <1 mg/mL
    Water
    77 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01205243 Infection, Human Immunodeficiency Virus I Drug: ZIAGEN ViiV Healthcare|GlaxoSmithKline 2010-11-01 2015-09-21
    NCT02101216 Psoriasis Drug: Prurisol|Drug: Ziagen Cellceutix Corporation Phase 1 2014-03-01 2015-03-02
    NCT01886638 HIV|Cardiovascular Disease Drug: Abacavir Bayside Health Phase 4 2013-08-01 2015-05-21
    NCT01973439 HIV Infection Other: Intervention 1: PK assessment while on Twice Daily Abacavir|Other: Intervention 2: PK assessment while on Once Daily Abacavir PENTA Foundation Phase 1 2006-07-01 2014-02-03
    NCT00765271 HIV Drug: Abacavir|Drug: Darunavir/ritonavir|Drug: Raltegravir St Stephens Aids Trust Phase 1 2008-05-01 2009-11-17
    NCT01220232 Healthy Volunteers Drug: Abacavir/Lamivudine|Drug: Abacavir/Lamivudine|Drug: Lersivirine Pfizer|ViiV Healthcare Phase 1 2010-11-01 2011-02-03
    NCT02093585 HIV Drug: abacavir (600 mg QD)|Drug: tenofovir (245 mg QD) Jan Gerstoft|Rigshospitalet, Denmark Phase 4 2014-01-01 2015-12-11
    NCT01153217 HIV Drug: Switch from tenofovir to abacavir Germans Trias i Pujol Hospital Phase 3 2010-07-01 2012-10-16
    NCT00002141 HIV Infections Drug: Abacavir sulfate Burroughs Wellcome|NIH AIDS Clinical Trials Information Service Phase 1 1994-07-01 2005-06-23
    NCT00002197 HIV Infections Drug: Abacavir sulfate Glaxo Wellcome|NIH AIDS Clinical Trials Information Service 2005-06-23
    NCT00002200 HIV Infections Drug: Abacavir sulfate Glaxo Wellcome|NIH AIDS Clinical Trials Information Service 2005-06-23
    NCT00002163 AIDS Dementia Complex|HIV Infections Drug: Abacavir sulfate Glaxo Wellcome|NIH AIDS Clinical Trials Information Service Phase 3 2005-06-23
    NCT00002198 HIV Infections Drug: Abacavir sulfate Glaxo Wellcome|NIH AIDS Clinical Trials Information Service Phase 1 2005-06-23
    NCT00011479 HIV Infections Drug: Abacavir sulfate National Institute of Allergy and Infectious Diseases (NIAID)|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Phase 1 2012-05-17
    NCT00002388 HIV Infections Drug: Abacavir sulfate Glaxo Wellcome|NIH AIDS Clinical Trials Information Service Phase 1 2005-06-23
    NCT01052701 Hepatitis C Other: Ribavrin|Drug: Abacavir plus Ribavirin Johns Hopkins University|GlaxoSmithKline|University of Nebraska Phase 1 2009-12-01 2011-06-22
    NCT01656122 HIV Drug: abacavir|Drug: 3TC The HIV Netherlands Australia Thailand Research Collaboration|Radboud University|amfAR, The Foundation for AIDS Research|PHPT/AMS Laboratory, Faculty of Associated Medical Sciences, Chiang Mai University|Chulalongkorn University|ViiV Healthcare Phase 2|Phase 3 2012-07-01 2016-02-18
    NCT00002390 HIV Infections Drug: Abacavir sulfate Glaxo Wellcome|NIH AIDS Clinical Trials Information Service Phase 2 2005-06-23
    NCT00314626 HIV Infections Drug: efavirenz|Drug: Abacavir+lamivudine Germans Trias i Pujol Hospital|Fundacio Lluita Contra la SIDA Phase 3 2004-11-01 2008-01-25
    NCT00002364 HIV Infections Drug: Abacavir sulfate Glaxo Wellcome|NIH AIDS Clinical Trials Information Service Phase 2 2005-06-23
    NCT02509195 HIV Drug: Triumeq St Stephens Aids Trust|ViiV Healthcare Phase 4 2015-07-01 2017-03-16

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 :
  • 收件地址 :
  • 电话号码 :
  • 单位名称 :
  • 产品货号 :
  • 产品规格 :
  • 发票抬头以及单位税号 :