Edoxaban是factor Xa选择性抑制剂,也是具有口服效应的抗凝药物。
Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Furugohri T, et al. J Thromb Haemost. 2008, 6(9), 1542-1549.
分子式 C31H40ClN7O8S2 |
分子量 738.27 |
CAS号 1229194-11-9 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 96 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02950168 | Atrial Fibrillation|Venous Thromboembolism | Procedure: Edoxaban | Daiichi Sankyo Inc.|SSS International Clinical Research GmBH|Hippocrates Research|IMS Health|ITEC Services | 2016-11-01 | 2016-10-28 | |
NCT02943993 | Venous Thromboembolism | Drug: Edoxaban | Daiichi Sankyo Inc.|Quintiles, Inc.|SSS International Medical Research GmbH|Hippocrates Research|IMS Health|ITEC Services | 2015-08-01 | 2016-10-26 | |
NCT02964949 | Atrial Fibrillation | Drug: Edoxaban | Daiichi Sankyo Inc.|Quintiles, Inc. | 2017-01-24 | 2017-02-28 | |
NCT02952599 | Venous Thromboembolism | Drug: Edoxaban | Daiichi Sankyo Inc.|Quintiles, Inc.|A+ Inc. | 2017-03-01 | 2016-11-01 | |
NCT03088072 | Non-Valvular Atrial Fibrillation|Left Atrial Appendage Closure | Drug: Edoxaban|Device: WATCHMAN LAA Closure|Drug: Aspirin and Clopidogrel|Drug: Aspirin and Warfarin | Scripps Health|Daiichi Sankyo Inc. | Phase 4 | 2017-03-29 | 2017-03-17 |
NCT02944019 | Atrial Fibrillation | Drug: Edoxaban | Daiichi Sankyo Inc.|Quintiles, Inc.|SSS International Clinical Research GmBH|Hippocrates Research|IMS Health|ITEC Services | 2015-08-01 | 2016-10-26 | |
NCT02951039 | Atrial Fibrillation | Drug: Edoxaban | Daiichi Sankyo Inc.|Quintiles, Inc.|A+ Inc. | 2017-03-01 | 2016-10-28 | |
NCT02567461 | Coronary Artery Disease | Drug: Edoxaban 60 mg|Drug: Edoxaban 30 mg|Drug: Clopidogrel 75 mg|Drug: Aspirin 81 mg | University of Florida|Daiichi Sankyo Inc. | Phase 4 | 2016-03-01 | 2017-03-15 |
NCT02448901 | Heart Failure | Drug: Edoxaban | LifeBridge Health|Daiichi Sankyo Inc. | 2015-04-01 | 2015-05-15 | |
NCT02561897 | Atrial Fibrillation | Drug: Edoxaban|Drug: Warfarin | Electrophysiology Research Foundation|Axio Research Corporation | Phase 4 | 2015-12-01 | 2017-03-08 |
NCT02221102 | Ischemia|Stroke|Cerebral Infarction | Drug: Aspirin|Drug: edoxaban|Drug: placebo | Xijing Hospital | Phase 2|Phase 3 | 2013-12-01 | 2014-08-18 |
NCT00781391 | Stroke|Atrial Fibrillation|Embolism | Drug: warfarin tablets|Drug: Edoxaban tablets (high dose regimen-60mg)|Drug: Edoxaban tablets (low dose regimen-30mg)|Drug: placebo warfarin|Drug: placebo edoxaban | Daiichi Sankyo Inc.|The TIMI Study Group | Phase 3 | 2008-11-01 | 2015-03-12 |
NCT02072434 | Atrial Fibrillation | Drug: edoxaban|Drug: Enoxaparin|Drug: Warfarin | Daiichi Sankyo Inc.|Covance|Quintiles, Inc. | Phase 3 | 2014-03-01 | 2017-01-03 |
NCT02866175 | Atrial Fibrillation | Drug: Edoxaban|Drug: Clopidogrel|Drug: Prasugrel|Drug: ticagrelor | Daiichi Sankyo Inc.|European Cardiovascular Research Institute|Kompetenznetz Vorhofflimmern e.V.|Chiltern International Inc. | Phase 3 | 2017-02-01 | 2016-08-10 |
NCT02207257 | Anticoagulation Reversal | Drug: PER977|Drug: Placebo | Perosphere, Inc.|Quintiles, Inc. | Phase 2 | 2014-03-01 | 2016-09-26 |
NCT00986154 | Venous Thromboembolism|Deep Vein Thrombosis (DVT)|Pulmonary Embolism (PE)|Thromboembolism|Venous Thrombosis | Drug: edoxaban tosylate(DU-176b)|Drug: low molecular weight heparin/unfractionated heparin|Drug: warfarin | Daiichi Sankyo Inc. | Phase 3 | 2009-10-01 | 2015-03-13 |
NCT01802775 | Peripheral Arterial Disease | Drug: edoxaban|Drug: Clopidogrel|Drug: Aspirin | Daiichi Sankyo Inc.|UMC Utrecht | Phase 2 | 2013-01-01 | 2015-11-18 |
NCT02942576 | Atrial Fibrillation | Drug: Edoxaban|Drug: VKA-Based Regimen|Drug: VKA-Based Regimen|Drug: VKA-Based Regimen|Drug: VKA-Based Regimen | Daiichi Sankyo Europe, GmbH|Daiichi Sankyo Inc. | Phase 3 | 2017-03-01 | 2016-10-21 |
NCT01662908 | Deep Vein Thrombosis|Venous Thrombosis | Drug: edoxaban tosylate|Drug: enoxaparin/unfractionated heparin|Drug: warfarin | Daiichi Sankyo Inc. | Phase 2 | 2012-08-01 | 2015-03-26 |
NCT02303431 | Deep Vein Thrombosis|Venous Thromboembolism | Drug: Edoxaban low dose|Drug: Edoxaban high dose | Daiichi Sankyo Inc.|Medpace, Inc. | Phase 1 | 2014-08-01 | 2017-03-22 |
NCT02798471 | Venous Thromboembolism (VTE)|Pulmonary Embolism|Deep Vein Thrombosis (DVT) | Drug: Edoxaban|Drug: Standard of Care | Daiichi Sankyo Inc. | Phase 3 | 2017-04-01 | 2017-03-23 |
NCT02943785 | Atrial Fibrillation | Drug: Edoxaban-based Regimen|Drug: VKA-based Regimen|Drug: VKA-based Regimen|Drug: VKA-based Regimen|Drug: VKA-based Regimen|Drug: VKA-based Regimen|Drug: VKA-based Regimen|Drug: VKA-based Regimen|Drug: VKA-based Regimen|Drug: VKA-based Regimen|Drug: Anti-platelet Therapy | Daiichi Sankyo Inc.|Chiltern International Inc. | Phase 3 | 2017-02-01 | 2016-10-31 |
NCT01826266 | Anticoagulant Reversal.|Reversal of Edoxaban Induced Anticoagulation. | Drug: PER977, Placebo | Perosphere, Inc. | Phase 1 | 2013-07-01 | 2014-09-25 |
NCT02047565 | Bleeding | Drug: 60mg edoxaban|Drug: 180mg edoxaban|Drug: 50 IU/kg Beriplex P/N|Drug: 25 IU/kg Beriplex P/N|Drug: 10 IU/kg Beriplex P/N | Daiichi Sankyo Inc. | Phase 1 | 2013-10-01 | 2015-01-14 |
NCT02618577 | Atrial High Rate Episodes | Drug: Edoxaban|Drug: ASA | German Atrial Fibrillation Network|Daiichi Sankyo Europe, GmbH|Deutsches Zentrum fr Herz-Kreislauf-Forschung (DZHK) | Phase 3 | 2016-02-01 | 2016-09-01 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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