Home > Factor Xa & > Edoxaban

Edoxaban

伊多塞班,DU-176b,DU176b,DU 176b

Edoxaban是factor Xa选择性抑制剂,也是具有口服效应的抗凝药物。

目录号
EY1546
EY1546
EY1546
纯度
99.21%
99.21%
99.21%
规格
5 mg
10 mg
50 mg
原价
485
685
1200
售价
485
685
1200
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Furugohri T, et al. J Thromb Haemost. 2008, 6(9), 1542-1549.

    分子式
    C31H40ClN7O8S2
    分子量
    738.27
    CAS号
    1229194-11-9
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    96 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02950168 Atrial Fibrillation|Venous Thromboembolism Procedure: Edoxaban Daiichi Sankyo Inc.|SSS International Clinical Research GmBH|Hippocrates Research|IMS Health|ITEC Services 2016-11-01 2016-10-28
    NCT02943993 Venous Thromboembolism Drug: Edoxaban Daiichi Sankyo Inc.|Quintiles, Inc.|SSS International Medical Research GmbH|Hippocrates Research|IMS Health|ITEC Services 2015-08-01 2016-10-26
    NCT02964949 Atrial Fibrillation Drug: Edoxaban Daiichi Sankyo Inc.|Quintiles, Inc. 2017-01-24 2017-02-28
    NCT02952599 Venous Thromboembolism Drug: Edoxaban Daiichi Sankyo Inc.|Quintiles, Inc.|A+ Inc. 2017-03-01 2016-11-01
    NCT03088072 Non-Valvular Atrial Fibrillation|Left Atrial Appendage Closure Drug: Edoxaban|Device: WATCHMAN LAA Closure|Drug: Aspirin and Clopidogrel|Drug: Aspirin and Warfarin Scripps Health|Daiichi Sankyo Inc. Phase 4 2017-03-29 2017-03-17
    NCT02944019 Atrial Fibrillation Drug: Edoxaban Daiichi Sankyo Inc.|Quintiles, Inc.|SSS International Clinical Research GmBH|Hippocrates Research|IMS Health|ITEC Services 2015-08-01 2016-10-26
    NCT02951039 Atrial Fibrillation Drug: Edoxaban Daiichi Sankyo Inc.|Quintiles, Inc.|A+ Inc. 2017-03-01 2016-10-28
    NCT02567461 Coronary Artery Disease Drug: Edoxaban 60 mg|Drug: Edoxaban 30 mg|Drug: Clopidogrel 75 mg|Drug: Aspirin 81 mg University of Florida|Daiichi Sankyo Inc. Phase 4 2016-03-01 2017-03-15
    NCT02448901 Heart Failure Drug: Edoxaban LifeBridge Health|Daiichi Sankyo Inc. 2015-04-01 2015-05-15
    NCT02561897 Atrial Fibrillation Drug: Edoxaban|Drug: Warfarin Electrophysiology Research Foundation|Axio Research Corporation Phase 4 2015-12-01 2017-03-08
    NCT02221102 Ischemia|Stroke|Cerebral Infarction Drug: Aspirin|Drug: edoxaban|Drug: placebo Xijing Hospital Phase 2|Phase 3 2013-12-01 2014-08-18
    NCT00781391 Stroke|Atrial Fibrillation|Embolism Drug: warfarin tablets|Drug: Edoxaban tablets (high dose regimen-60mg)|Drug: Edoxaban tablets (low dose regimen-30mg)|Drug: placebo warfarin|Drug: placebo edoxaban Daiichi Sankyo Inc.|The TIMI Study Group Phase 3 2008-11-01 2015-03-12
    NCT02072434 Atrial Fibrillation Drug: edoxaban|Drug: Enoxaparin|Drug: Warfarin Daiichi Sankyo Inc.|Covance|Quintiles, Inc. Phase 3 2014-03-01 2017-01-03
    NCT02866175 Atrial Fibrillation Drug: Edoxaban|Drug: Clopidogrel|Drug: Prasugrel|Drug: ticagrelor Daiichi Sankyo Inc.|European Cardiovascular Research Institute|Kompetenznetz Vorhofflimmern e.V.|Chiltern International Inc. Phase 3 2017-02-01 2016-08-10
    NCT02207257 Anticoagulation Reversal Drug: PER977|Drug: Placebo Perosphere, Inc.|Quintiles, Inc. Phase 2 2014-03-01 2016-09-26
    NCT00986154 Venous Thromboembolism|Deep Vein Thrombosis (DVT)|Pulmonary Embolism (PE)|Thromboembolism|Venous Thrombosis Drug: edoxaban tosylate(DU-176b)|Drug: low molecular weight heparin/unfractionated heparin|Drug: warfarin Daiichi Sankyo Inc. Phase 3 2009-10-01 2015-03-13
    NCT01802775 Peripheral Arterial Disease Drug: edoxaban|Drug: Clopidogrel|Drug: Aspirin Daiichi Sankyo Inc.|UMC Utrecht Phase 2 2013-01-01 2015-11-18
    NCT02942576 Atrial Fibrillation Drug: Edoxaban|Drug: VKA-Based Regimen|Drug: VKA-Based Regimen|Drug: VKA-Based Regimen|Drug: VKA-Based Regimen Daiichi Sankyo Europe, GmbH|Daiichi Sankyo Inc. Phase 3 2017-03-01 2016-10-21
    NCT01662908 Deep Vein Thrombosis|Venous Thrombosis Drug: edoxaban tosylate|Drug: enoxaparin/unfractionated heparin|Drug: warfarin Daiichi Sankyo Inc. Phase 2 2012-08-01 2015-03-26
    NCT02303431 Deep Vein Thrombosis|Venous Thromboembolism Drug: Edoxaban low dose|Drug: Edoxaban high dose Daiichi Sankyo Inc.|Medpace, Inc. Phase 1 2014-08-01 2017-03-22
    NCT02798471 Venous Thromboembolism (VTE)|Pulmonary Embolism|Deep Vein Thrombosis (DVT) Drug: Edoxaban|Drug: Standard of Care Daiichi Sankyo Inc. Phase 3 2017-04-01 2017-03-23
    NCT02943785 Atrial Fibrillation Drug: Edoxaban-based Regimen|Drug: VKA-based Regimen|Drug: VKA-based Regimen|Drug: VKA-based Regimen|Drug: VKA-based Regimen|Drug: VKA-based Regimen|Drug: VKA-based Regimen|Drug: VKA-based Regimen|Drug: VKA-based Regimen|Drug: VKA-based Regimen|Drug: Anti-platelet Therapy Daiichi Sankyo Inc.|Chiltern International Inc. Phase 3 2017-02-01 2016-10-31
    NCT01826266 Anticoagulant Reversal.|Reversal of Edoxaban Induced Anticoagulation. Drug: PER977, Placebo Perosphere, Inc. Phase 1 2013-07-01 2014-09-25
    NCT02047565 Bleeding Drug: 60mg edoxaban|Drug: 180mg edoxaban|Drug: 50 IU/kg Beriplex P/N|Drug: 25 IU/kg Beriplex P/N|Drug: 10 IU/kg Beriplex P/N Daiichi Sankyo Inc. Phase 1 2013-10-01 2015-01-14
    NCT02618577 Atrial High Rate Episodes Drug: Edoxaban|Drug: ASA German Atrial Fibrillation Network|Daiichi Sankyo Europe, GmbH|Deutsches Zentrum fr Herz-Kreislauf-Forschung (DZHK) Phase 3 2016-02-01 2016-09-01

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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