Home > mAChR & mAChR & > Neostigmine Bromide

Neostigmine Bromide

溴化新斯的明,普鲁色林,Prostigmin,Vagostigmin,Eustigmin,Neoserine bromide

Neostigmine Bromide是胆碱酯酶抑制剂，可作用于重症肌无力。

目录号
EY1544
EY1544
纯度
99.17%
99.17%
规格
100 mg
200 mg
原价
586
792
售价
586
792
库存
现货
现货
订购
订购
订购
订购
订购
订购
具体折扣请咨询客服

  • 生物活性

    Neostigmine Bromide is a reversible acetylcholinesterase inhibitor.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Xiang Xu et. Al. Journal of Biological Chemistry, 285(24), 18139-18143 (2010).
    [2] Jessica Kåhlin et. Al. Experimental Physiology, 99(8), 1089-1098 (2014).
    [3] Nadine Pinder et. Al. Clinical Chemistry and Laboratory Medicine, 53(8), 1259-1264 (2015).
    [4] Ute Burkhardt et. Al. Neuroscience Letters, 572, 48-52 (2014).

    分子式
    C12H19BrN2O2    		 分子量
    303.2    		 CAS号
    114-80-7    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    <1 mg/mL    		 Water
    61 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT03058263 Muscle Relaxant|General Anesthesia Drug: Dose of Neostigmine Indonesia University Phase 1|Phase 2 2016-10-01 2017-02-15
    NCT00451100 Anesthesia, General Drug: Sugammadex|Drug: neostigmine Merck Sharp & Dohme Corp. Phase 3 2005-11-01 2016-05-13
    NCT02543658 Acute Pancreatitis|Intra-abdominal Hypertension Drug: Neostigmine|Drug: The traditional treatment The First Affiliated Hospital of Nanchang University Phase 1 2015-09-01 2015-09-04
    NCT00451217 Anesthesia, General Drug: Sugammadex|Drug: neostigmine Merck Sharp & Dohme Corp. Phase 3 2005-11-01 2016-05-13
    NCT02909439 Incomplete Reversal of Neuromuscular Block Drug: Sugammadex|Drug: Neostigmine Stony Brook University|Merck Sharp & Dohme Corp. Phase 4 2016-09-01 2016-09-16
    NCT02403063 Respiratory Muscles|Electromyography Drug: Sugammadex|Drug: Neostigmine|Drug: Neostigmine-sugammadex Onze Lieve Vrouw Hospital Phase 4 2015-09-01 2015-11-19
    NCT02433808 Residual Neuromuscular Block Drug: Neostigmine Group|Other: No Neostigmine group NorthShore University HealthSystem Research Institute Phase 4 2015-04-01 2016-03-28
    NCT02284412 Respiratory-Gated Imaging Techniques Drug: Neostigmine|Drug: Sugammadex|Drug: Water for injection Onze Lieve Vrouw Hospital|Universiteit Antwerpen|MSD Belgium BVBA Phase 4 2014-12-01 2015-04-20
    NCT02861131 Postoperative Complications|Neuromuscular Blockade Drug: Sugammadex|Drug: Neostigmine Oregon Health and Science University|Merck Sharp & Dohme Corp. Phase 4 2017-01-01 2017-01-15
    NCT00473694 Anesthesia, General Drug: sugammadex|Drug: neostigmine Merck Sharp & Dohme Corp. Phase 3 2005-11-01 2016-05-13
    NCT00676377 Ileus Drug: Neostigmine|Drug: Saline Baqiyatallah Medical Sciences University Phase 4 2007-08-01 2008-05-12
    NCT02666014 Postoperative Nausea and Vomiting Drug: Neuromuscular reversal by Sugammadex|Drug: Neuromuscular reversal by Neostigmine|Drug: Atropine sulfate-diphenoxylate hydrochloride combination KK Women's and Children's Hospital|Singhealth Foundation Phase 3 2015-06-01 2016-08-30
    NCT01050543 Neuromuscular Blockade Drug: sugammadex|Drug: neostigmine Merck Sharp & Dohme Corp. Phase 3 2010-02-01 2015-07-13
    NCT00895609 Neuromuscular Block Drug: Sugammadex, Neostigmine, Saline Technische Universitt Mnchen Phase 4 2009-03-01 2013-03-18
    NCT00724932 Anesthesia, General Drug: Rocuronium|Drug: Sugammadex|Drug: Neostigmine|Drug: Atropine Merck Sharp & Dohme Corp. Phase 3 2008-07-01 2015-02-26
    NCT02697929 Postoperative Residual Curarization|Liver Transplantation Drug: sugammadex|Drug: Neostigmine Azienda Ospedaliera S. Maria della Misericordia 2014-01-01 2017-01-28
    NCT02330172 Neuromuscular Blockade Other: Injection of neostigmine or sugammadex Seoul National University Hospital Phase 4 2014-12-01 2016-09-06
    NCT00825812 Anesthesia, General|Neuromuscular Blockade Drug: Sugammadex|Drug: neostigmine Merck Sharp & Dohme Corp. Phase 3 2010-01-01 2015-10-30
    NCT00675792 Anesthesia Drug: Sugammadex|Drug: Neostigmine|Drug: Rocuronium Merck Sharp & Dohme Corp. Phase 3 2008-05-01 2015-02-24
    NCT03019835 Mivacurium|Neostigmine|Residual Paralysis Drug: Neostigmine (40 mcg / kg) at different time of neuromuscular block's recovery|Other: Spontaneous recovery Universit Libre de Bruxelles 2016-12-01 2017-01-12
    NCT02944175 Supratentorial Brain Tumor Surgery Drug: Sugammadex|Drug: Neostigmine Mansoura University 2016-07-01 2016-10-21
    NCT02414880 Cirrhosis and Chronic Liver Disease Drug: Sugammadex|Drug: Neostigmine|Drug: Rocuronium Cairo University|National Liver Institute, Egypt Phase 4 2014-12-01 2016-01-30
    NCT03021772 Adjuvants, Anesthesia Drug: Neostigmine|Drug: Dexamethasone Assiut University Phase 2|Phase 3 2017-01-01 2017-01-26
    NCT00847938 Anesthesia Drug: neostigmine|Drug: neostigmine|Drug: neostigmine Centre Hospitalier Departemental Vendee Phase 3 2009-03-01 2009-11-30
    NCT02256280 Neuromuscular Blockade Drug: Sugammadex|Drug: Neostigmine Fondazione IRCCS Istituto Nazionale dei Tumori, Milano Phase 4 2015-01-01 2016-02-24

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 ：
  • 收件地址 ：
  • 电话号码 ：
  • 单位名称 ：
  • 产品货号 ：
  • 产品规格 ：
  • 发票抬头以及单位税号 ：