Tetracycline hydrochloride 是广谱聚酮类抗生素。
Tetracycline HCl is a hydrochloride salt of tetracycline that is a broad-spectrum polyketide antibiotic.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] E Kheadr et. Al. Antimicrobial Agents and Chemotherapy, 51(1), 169-174 (2007).
[2] Hyekyung P Cho et. Al. ACS Chemical Neuroscience, 5(7), 597-610 (2014).
[3] Yuqin Qiao et. Al. Biomaterials, 35(25), 6882-6897 (2014).
分子式 C22H25ClN2O8 |
分子量 480.9 |
CAS号 64-75-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 100 mg/mL |
Water 100 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01880515 | Skin Rash|Lung Cancer | Drug: Tetracycline | Instituto Nacional de Cancerologia de Mexico | Phase 2 | 2010-12-01 | 2014-01-15 |
NCT01763437 | Chalazia|Chalazion | Drug: Tetracycline | The Cleveland Clinic | Early Phase 1 | 2014-03-01 | 2017-01-10 |
NCT02057926 | Ridge Preservation Technique | Drug: The effect of tetracycline in degradation and permeability of collagen membranes. | Universitat Internacional de Catalunya | Phase 2 | 2009-11-01 | 2014-02-05 |
NCT02259543 | Gingival Recession | Other: Root conditioning with citric acid+tetracycline solution | University of Sao Paulo|Fundao de Amparo Pesquisa do Estado de So Paulo | 2011-08-01 | 2014-10-05 | |
NCT00091247 | Unspecified Adult Solid Tumor, Protocol Specific | Drug: tetracycline hydrochloride|Other: placebo | Alliance for Clinical Trials in Oncology|National Cancer Institute (NCI) | 2004-12-01 | 2017-03-14 | |
NCT00336154 | Epidermolysis Bullosa | Drug: tetracyclin | Rambam Health Care Campus | Phase 4 | 2006-06-12 | |
NCT00355459 | Dry Eye Syndrome | Drug: Tetracycline: Doxycycline analog | University of Texas Southwestern Medical Center | 2005-08-01 | 2011-03-21 | |
NCT01293643 | Vaginosis, Bacterial|Candidiasis, Vulvovaginal | Drug: 100 mg clindamycin /800 mg ketoconazole vaginal ovule|Drug: 100 mg tetracycline hydrochloride /50 mg amphotericin B cream | Merck Sharp & Dohme Corp. | Phase 3 | 2010-05-01 | 2015-08-07 |
NCT02175927 | Helicobacter Pylori Treatment Failure | Drug: Lansoprazole|Drug: Bismuth Potassium Citrate|Drug: Metronidazole|Drug: Amoxicillin|Drug: Tetracycline | Shanghai Jiao Tong University School of Medicine | Phase 4 | 2014-07-01 | 2016-02-29 |
NCT00469261 | Myocardial Infarction|Left Ventricular Remodeling | Drug: Doxycycline|Drug: Current medical therapy for AMI | Careggi Hospital | Phase 2 | 2007-05-01 | 2012-09-24 |
NCT00669955 | Helicobacter Infections | Drug: Omeprazole, amoxicillin, clarithromycin|Drug: Pylera (Bismuth subcitrate potassium, metronidazole, tetracycline) given in combination with omeprazole | Forest Laboratories | Phase 3 | 2008-06-01 | 2017-02-08 |
NCT00889356 | Candidiasis|Bacterial Vaginosis | Drug: Clindamycin 100mg and Ketoconazole 400mg|Drug: Tetracycline 100mg and Amphotericin B 50mg | Zodiac Produtos Farmaceuticos S.A. | Phase 3 | 2009-09-01 | 2009-04-27 |
NCT02576652 | Osteoporosis | Other: Tetracycline/Demeclocycline | Amgen | Phase 4 | 2015-12-01 | 2016-12-07 |
NCT02978157 | Helicobacter Pylori Infection | Drug: esomeprazole+amox+levo|Drug: esomeprazole+bismuth+tetra+levo | Kaohsiung Veterans General Hospital.|Kaohsiung Medical University Chung-Ho Memorial Hospital | 2015-02-01 | 2016-11-29 | |
NCT01573975 | Helicobacter Pylori Infection | Drug: 5RA-5RCM|Drug: 5RA-5RCT|Drug: 10RCA | Buddhist Tzu Chi General Hospital | Phase 4 | 2009-01-01 | 2012-04-09 |
NCT00243893 | Aneurysms|Arteriovenous Malformations | Drug: minocycline|Drug: doxycycline | University of California, San Francisco|National Institute of Neurological Disorders and Stroke (NINDS) | Phase 1 | 2004-07-01 | 2013-10-08 |
NCT00347776 | Trichiasis | Drug: azithromycin|Drug: topical tetracycline | Johns Hopkins University|National Eye Institute (NEI)|Project ORBIS | Phase 4 | 2001-08-01 | 2013-04-03 |
NCT01010295 | Non-Hodgkin Lymphoma | Drug: doxycycline (tetracycline) | International Extranodal Lymphoma Study Group (IELSG) | Phase 2 | 2006-09-01 | 2013-11-22 |
NCT01335334 | H. Pylori Infection | Drug: bismuth subcitrate potassium, metronidazole,tetracycline hydrochloride and omeprazole | The University of Texas Health Science Center, Houston | Phase 4 | 2011-03-01 | 2011-04-13 |
NCT00591162 | Burn | Drug: Tetracycline|Radiation: Duel Energy X-Ray Absorptiometry (DEXA)|Procedure: Bone Biopsy | The University of Texas Medical Branch, Galveston | Phase 2|Phase 3 | 1992-10-01 | 2014-06-05 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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