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Varenicline Tartrate

酒石酸伐尼克兰,酒石酸伐伦克林,CP526555-18,CP 526555-18

Varenicline Tartrate是一种烟碱类AChR激动剂,用于治疗吸烟成瘾。

目录号
EY1533
EY1533
EY1533
纯度
99.63%
99.63%
99.63%
规格
5 mg
10 mg
50 mg
原价
720
1115
3400
售价
720
1115
3400
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Varenicline Tartrate is a nicotinic AChR partial agonist, used to treat nicotine addiction.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Rollema H, et al. Neuropharmacology, 2007, 52(3), 985-994.

    分子式
    C13H13N3·C4H6O6
    分子量
    361.35
    CAS号
    375815-87-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    2 mg/mL
    Water
    72 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01571167 Methamphetamine Dependence|Methamphetamine Abuse|Substance Abuse Drug: Placebo|Drug: Varenicline|Drug: Varenicline Baylor College of Medicine|National Institute on Drug Abuse (NIDA) Phase 1 2011-01-01 2013-06-12
    NCT00895557 Varenicline and the Blunting of Cocaine Cues Drug: chantix University of Pennsylvania|National Institute on Drug Abuse (NIDA) Phase 2 2007-12-01 2016-09-06
    NCT00813800 Smoking|Bipolar Disorder|Depression Drug: Varenicline Mark Frye|Pfizer|Mayo Clinic 2009-01-01 2011-12-23
    NCT00860028 Nicotine Dependence|Smoking|Heavy Drinking Drug: Varenicline Yale University|National Institute on Alcohol Abuse and Alcoholism (NIAAA) Phase 2 2008-10-01 2013-01-28
    NCT00661765 Smoking Cessation Drug: varenicline tartrate|Drug: varenicline free base Pfizer Phase 1 2008-04-01 2009-04-22
    NCT01010204 Smoking Cessation|Bipolar Disorder Drug: Varenicline (Chantix)|Drug: Placebo University of Pittsburgh|National Institute of Mental Health (NIMH)|Pfizer Phase 4 2010-01-01 2015-04-07
    NCT01341080 Parkinson Disease Drug: Varenicline|Drug: Sugar pill Rush University Medical Center Phase 2 2010-11-01 2014-07-15
    NCT00733967 Methamphetamine Dependence|Substance Abuse|Methamphetamine Abuse Drug: Varenicline|Drug: Placebo Baylor College of Medicine|National Institute on Drug Abuse (NIDA) Phase 1 2008-01-01 2012-07-25
    NCT00525837 Depressive Disorder|Smoking Drug: fixed dose varenicline|Drug: varenicline Butler Hospital|Brown University 2007-09-01 2014-10-03
    NCT01632189 Nicotine Dependence Drug: Varenicline Centre for Addiction and Mental Health|Ontario Lung Association|Pfizer 2012-09-01 2016-01-26
    NCT00948155 Nicotine Dependence Drug: Varenicline University of Pennsylvania|Pfizer Phase 4 2009-01-01 2014-12-15
    NCT01228175 Smoking Addiction Drug: Placebo|Drug: Varenicline The Mind Research Network|National Institute on Drug Abuse (NIDA) Phase 4 2010-03-01 2016-09-16
    NCT00602927 Nicotine Dependence Drug: Varenicline|Drug: Placebo University of Pennsylvania|Pfizer|National Cancer Institute (NCI) 2007-11-01 2011-05-06
    NCT01387425 Smoking Cessation|Diabetes Drug: varenicline|Drug: placebo tablet is made of lactose Universita degli Studi di Catania 2011-06-01 2015-12-01
    NCT01378858 Tobacco Use Disorder|Medication Adherence Behavioral: Varenicline treatment as usual or directly observed therapy Albert Einstein College of Medicine, Inc.|National Institute on Drug Abuse (NIDA) 2011-07-01 2015-01-14
    NCT01347112 Smoking|Tobacco Dependence|Alcohol Dependence Drug: Varenicline|Drug: placebo Mayo Clinic Phase 2|Phase 3 2011-06-01 2014-05-01
    NCT00731562 Pharmacokinetics|Bioavailability|Smoking Cessation Drug: Varenicline Tartrate Controlled Release|Drug: Varenicline Tartrate Controlled Release Pfizer Phase 1 2008-07-01 2010-01-07
    NCT01092702 Tobacco Abstinence Drug: Varenicline Mayo Clinic Phase 2|Phase 3 2008-04-01 2011-04-15
    NCT00749944 Smoking Cessation Drug: varenicline|Drug: placebo Pfizer Phase 4 2008-09-01 2010-08-24
    NCT01934023 Schizophrenia Drug: Varenicline|Drug: Placebo Centre for Addiction and Mental Health|Pfizer Phase 2 2013-09-01 2015-08-24
    NCT01061710 Smoking Cessation Drug: varenicline Pfizer Phase 4 2010-07-01 2015-01-27

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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