Varenicline Tartrate是一种烟碱类AChR激动剂,用于治疗吸烟成瘾。
Varenicline Tartrate is a nicotinic AChR partial agonist, used to treat nicotine addiction.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Rollema H, et al. Neuropharmacology, 2007, 52(3), 985-994.
分子式 C13H13N3·C4H6O6 |
分子量 361.35 |
CAS号 375815-87-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 2 mg/mL |
Water 72 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01571167 | Methamphetamine Dependence|Methamphetamine Abuse|Substance Abuse | Drug: Placebo|Drug: Varenicline|Drug: Varenicline | Baylor College of Medicine|National Institute on Drug Abuse (NIDA) | Phase 1 | 2011-01-01 | 2013-06-12 |
NCT00895557 | Varenicline and the Blunting of Cocaine Cues | Drug: chantix | University of Pennsylvania|National Institute on Drug Abuse (NIDA) | Phase 2 | 2007-12-01 | 2016-09-06 |
NCT00813800 | Smoking|Bipolar Disorder|Depression | Drug: Varenicline | Mark Frye|Pfizer|Mayo Clinic | 2009-01-01 | 2011-12-23 | |
NCT00860028 | Nicotine Dependence|Smoking|Heavy Drinking | Drug: Varenicline | Yale University|National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Phase 2 | 2008-10-01 | 2013-01-28 |
NCT00661765 | Smoking Cessation | Drug: varenicline tartrate|Drug: varenicline free base | Pfizer | Phase 1 | 2008-04-01 | 2009-04-22 |
NCT01010204 | Smoking Cessation|Bipolar Disorder | Drug: Varenicline (Chantix)|Drug: Placebo | University of Pittsburgh|National Institute of Mental Health (NIMH)|Pfizer | Phase 4 | 2010-01-01 | 2015-04-07 |
NCT01341080 | Parkinson Disease | Drug: Varenicline|Drug: Sugar pill | Rush University Medical Center | Phase 2 | 2010-11-01 | 2014-07-15 |
NCT00733967 | Methamphetamine Dependence|Substance Abuse|Methamphetamine Abuse | Drug: Varenicline|Drug: Placebo | Baylor College of Medicine|National Institute on Drug Abuse (NIDA) | Phase 1 | 2008-01-01 | 2012-07-25 |
NCT00525837 | Depressive Disorder|Smoking | Drug: fixed dose varenicline|Drug: varenicline | Butler Hospital|Brown University | 2007-09-01 | 2014-10-03 | |
NCT01632189 | Nicotine Dependence | Drug: Varenicline | Centre for Addiction and Mental Health|Ontario Lung Association|Pfizer | 2012-09-01 | 2016-01-26 | |
NCT00948155 | Nicotine Dependence | Drug: Varenicline | University of Pennsylvania|Pfizer | Phase 4 | 2009-01-01 | 2014-12-15 |
NCT01228175 | Smoking Addiction | Drug: Placebo|Drug: Varenicline | The Mind Research Network|National Institute on Drug Abuse (NIDA) | Phase 4 | 2010-03-01 | 2016-09-16 |
NCT00602927 | Nicotine Dependence | Drug: Varenicline|Drug: Placebo | University of Pennsylvania|Pfizer|National Cancer Institute (NCI) | 2007-11-01 | 2011-05-06 | |
NCT01387425 | Smoking Cessation|Diabetes | Drug: varenicline|Drug: placebo tablet is made of lactose | Universita degli Studi di Catania | 2011-06-01 | 2015-12-01 | |
NCT01378858 | Tobacco Use Disorder|Medication Adherence | Behavioral: Varenicline treatment as usual or directly observed therapy | Albert Einstein College of Medicine, Inc.|National Institute on Drug Abuse (NIDA) | 2011-07-01 | 2015-01-14 | |
NCT01347112 | Smoking|Tobacco Dependence|Alcohol Dependence | Drug: Varenicline|Drug: placebo | Mayo Clinic | Phase 2|Phase 3 | 2011-06-01 | 2014-05-01 |
NCT00731562 | Pharmacokinetics|Bioavailability|Smoking Cessation | Drug: Varenicline Tartrate Controlled Release|Drug: Varenicline Tartrate Controlled Release | Pfizer | Phase 1 | 2008-07-01 | 2010-01-07 |
NCT01092702 | Tobacco Abstinence | Drug: Varenicline | Mayo Clinic | Phase 2|Phase 3 | 2008-04-01 | 2011-04-15 |
NCT00749944 | Smoking Cessation | Drug: varenicline|Drug: placebo | Pfizer | Phase 4 | 2008-09-01 | 2010-08-24 |
NCT01934023 | Schizophrenia | Drug: Varenicline|Drug: Placebo | Centre for Addiction and Mental Health|Pfizer | Phase 2 | 2013-09-01 | 2015-08-24 |
NCT01061710 | Smoking Cessation | Drug: varenicline | Pfizer | Phase 4 | 2010-07-01 | 2015-01-27 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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