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Dihydroartemisinin

双氢青蒿素,DHA

Dihydroartemisinin (DHA)是一种Artemisinin 的半合成衍生物，从传统中药Artemisia annua分离而来的。

目录号
EY1514
EY1514
纯度
99.68%
99.68%
规格
50 mg
100 mg
原价
499.00
699.00
售价
499.00
699.00
库存
现货
现货
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  • 生物活性

    Dihydroartemisinin (DHA) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Chen Q, et al. Dihydroartemisinin alleviates bile duct ligation-induced liver fibrosis and hepatic stellate cell activation by interfering with the PDGF-βR/ERK signaling pathway. Int Immunopharmacol. 2016 May;34:250-8.
    [2] Huang Z, et al. Dihydroartemisinin inhibits cell proliferation by induced G1 arrest and apoptosis in human nasopharyngealcarcinoma cells. J Cancer Res Ther. 2016 Jan-Mar;12(1):244-7.

    分子式
    C15H24O5    		 分子量
    284.35    		 CAS号
    71939-50-9    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    57 mg/mL     		Water
    <1 mg/mL    		 Ethanol
    13 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01392014 Malaria Drug: dihydroartemisinin-piperaquine|Drug: dihydroartemisinin-piperaquine + primaquine Indonesia University Phase 4 2008-12-01 2011-07-08
    NCT01231113 Pregnancy Complicated by Malaria as Antepartum Condition Drug: artesunate-amodiaquine|Drug: Dihydroartemisinin-piperaquine Kwame Nkrumah University of Science and Technology|Malaria Capacity Development Consortium Phase 3 2011-07-01 2016-02-23
    NCT02324738 Healthy Drug: Mefloquine and Dihydroartemisinin-piperaquine|Other: Wash-out period|Drug: Mefloquine University of Oxford Phase 4 2015-01-01 2015-11-02
    NCT02909712 Malaria|Pregnancy|Cardiotoxicity|Parasitemia Drug: sulfadoxine-pyrimethamine (SP)|Drug: dihydroartemisinin-piperaquine (DHA-PQP) London School of Hygiene and Tropical Medicine|Kilimanjaro Christian Medical Centre, Tanzania|National Institute for Medical Research, Tanzania Phase 2 2016-09-01 2016-09-19
    NCT02605720 Malaria Drug: Dihydroartemisinin-piperaquine Lihir Medical Centre|Walter and Eliza Hall Institute of Medical Research|Papua New Guinea Institute of Medical Research|Barcelona Institute for Global Health Phase 3 2015-09-01 2016-03-02
    NCT01525511 Healthy Drug: A|Drug: B University of Oxford Phase 1 2012-06-01 2013-08-27
    NCT02590627 Malaria Drug: Artemether-lumefantrine|Drug: Dihydroartemisinin-piperaquine National Institute for Medical Research, Tanzania|Ministry of Health and Social Welfare, Tanzania|World Health Organization Phase 4 2014-05-01 2015-10-28
    NCT01389557 Malaria Drug: Dihydroartemisinin-piperaquine with primaquine Indonesia University Phase 4 2011-02-01 2012-03-22
    NCT01878357 Malaria Drug: dihydroartemisinin-piperaquine|Drug: primaquine Indonesia University|Walter and Eliza Hall Institute of Medical Research Phase 4 2013-06-01 2014-01-23
    NCT02671175 Malaria|Severe Anemia Drug: dihydroartemisinin-piperaquine|Drug: dihydroartemisinin-piperaquine placebo Liverpool School of Tropical Medicine|The Research Council of Norway|Kenya Medical Research Institute|Makerere University Phase 3 2016-05-01 2016-10-05
    NCT02259426 Malaria|Asymptomatic Malaria|Plasmodium Falciparum Drug: Dihydroartemisinin-piperaquine combination (Artekin)|Drug: Primaquine London School of Hygiene and Tropical Medicine|Radboud University|International centre for Insect Physiology and Ecology (ICIPE) Phase 3 2014-10-01 2016-01-13
    NCT02353494 Plasmodium Falciparum Infection|Plasmodium Vivax Infection Drug: Dihydroartemisinin-Piperaquine Menzies School of Health Research|Eijkman Institute for Molecular Biology, Jakarta, Indonesia|World Health Organization 2015-03-01 2017-01-31
    NCT02788864 Malaria Drug: Arterakine (DHA/piperaquine)|Drug: Placebo Oxford University Clinical Research Unit, Vietnam|Binh Phuoc Malaria Control Centre|Bu Gia Map National Park, Binh Phuoc Province, Vietnam Phase 4 2016-05-20 2017-03-06
    NCT01326754 Malaria, Falciparum Drug: Artemether-lumefantrine combination|Drug: Artesunate-amodiaquine combination|Drug: Dihydroartemisinin-piperaquine Centers for Disease Control and Prevention|University of Malawi College of Medicine 2011-08-01 2013-02-21
    NCT02199951 Malaria Drug: Dihydroartemisinin and piperaquine INDEPTH Network|Ministry of Health, Ghana|Ifakara Health Research and Development Centre|Ministry of Health, Burkina Faso|Centro de Investigacao em Saude de Manhica Phase 4 2013-09-01 2014-07-24
    NCT00941785 Malaria Drug: DHA-PQ|Drug: SP-AQ London School of Hygiene and Tropical Medicine|BEIJING HOLLEY-COTEC PHARMACEUTICALS CO. LTD. Phase 2|Phase 3 2009-07-01 2011-03-18
    NCT01640574 Vivax Malaria Drug: Dihydroartemisinin-Piperaquine|Drug: Dihydroartemisinin-Piperaquine|Drug: Chloroquine|Drug: Chloroquine University of Oxford Phase 3 2012-02-01 2016-04-27
    NCT02654730 Malaria Drug: Dihydroartemisinin-piperaquine (DHAP) administered to G6PD deficient|Drug: Dihydroartemisinin-piperaquine (DHAP) + 0.25 mg/kg primaquine administered to G6PD deficient|Drug: Dihydroartemisinin-piperaquine (DHAP) + 0.4 mg/kg primaquine administered to G6PD deficient|Drug: Dihydroartemisinin-piperaquine (DHAP) + 0.25 mg/kg primaquine administered to G6PD normal|Drug: Dihydroartemisinin-piperaquine (DHAP) + 0.4 mg/kg primaquine administered to G6PD normal London School of Hygiene and Tropical Medicine|Medical Research Council Unit, The Gambia Phase 2|Phase 3 2015-12-01 2016-09-08
    NCT01669941 Pregnancy|Malaria Drug: IPTp-SP|Drug: IPTp-DP|Drug: ISTp-DP Kenya Medical Research Institute|Centers for Disease Control and Prevention|Liverpool School of Tropical Medicine|London School of Hygiene and Tropical Medicine Phase 4 2012-08-01 2017-03-03
    NCT00373607 Malaria Drug: Dihydroartemisin-piperaquine|Drug: Mefloquine + Artesunate Institute of Tropical Medicine, Belgium Phase 3 2003-07-01 2010-09-13
    NCT01075945 Malaria Drug: Dihydroartemisinin- piperaquine|Drug: artemether- lumefantrine University of Khartoum|Southeast University, China Phase 4 2010-02-01 2010-02-24
    NCT00845533 Uncomplicated Malaria Drug: Dihydroartemisinin-Piperaquine University of California, San Francisco|Holley-Cotec Pharmaceuticals Co., LTD.|Mahidol University Phase 4 2007-08-01 2014-01-15
    NCT02184637 Malaria, Vivax Drug: Tafenoquine|Drug: Dihydroartemisinin + Piperaquine tetraphosphate|Drug: Artemether + Lumefantrine GlaxoSmithKline|Medicines for Malaria Venture Phase 1 2014-07-01 2015-04-16
    NCT01704508 Malaria Drug: Artemether-lumefantrine|Drug: Dihydroartemisinin-piperaquine Bandim Health Project|Karolinska Institutet Phase 4 2012-11-01 2013-12-05
    NCT02940756 Malaria Drug: artesunate-amodiaquine|Drug: artemether-lumefantrine|Drug: Dihydroartemisinine-piperaquine Ministry of Public Health, Democratic Republic of the Congo Phase 4 2016-11-01 2016-10-20

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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