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Adapalene

阿达帕林,CD-271,CD271,CD 271

Adapalene (阿达帕林; CD-271; Differin) 是合成的维甲酸,为维甲酸受体(RAR)激动剂。

目录号
EY1512
EY1512
EY1512
纯度
99.41%
99.41%
99.41%
规格
50 mg
100 mg
500 mg
原价
480
779
1500
售价
480
779
1500
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Adapalene is a dual RAR and RXR agonist, used in the treatment of acne.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Brogden RN, et al. Drugs, 1997, 53(3), 511-519.

    分子式
    C28H28O3
    分子量
    412.52
    CAS号
    106685-40-9
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    >5 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01485367 Senile Purpura Drug: adapalene gel 0.3% Multispecialty Aesthetic Clinical Research Organization|Galderma Laboratories, L.P. Phase 2 2011-12-01 2012-04-19
    NCT01213199 Acne Scars Drug: Adapalene Galderma Phase 2 2011-03-01 2015-03-09
    NCT01406080 Photoaging|Photodamage Drug: Adapalene|Drug: Tretinoin Galderma Brasil Ltda. Phase 3 2013-01-01 2013-01-22
    NCT00598832 Acne Vulgaris Drug: Adapalene lotion 0.1%|Drug: Adapalene Lotion Vehicle Galderma Phase 3 2007-11-01 2011-03-21
    NCT02173054 Acne Other: Adapalene gel with Eucerin|Other: Adapalene gel|Other: Adapalene gel with placebo moisturizer Mahidol University Phase 3 2014-07-01 2016-11-28
    NCT00599521 Acne Vulgaris Drug: Adapalene lotion 0.1%|Drug: Adapalene Lotion Vehicle Galderma Phase 3 2007-11-01 2011-03-21
    NCT02411942 Acne Vulgaris Drug: Adapalene Gel 0.3%|Drug: Differin|Drug: Placebo Taro Pharmaceuticals USA Phase 1 2014-08-01 2015-04-07
    NCT01046565 Skin Manifestations Drug: adapalene cream 0.1%|Drug: adapalene lotion 0.1% Galderma Laboratories, L.P. Phase 1 2010-01-01 2011-11-15
    NCT01046396 Skin Manifestations Drug: adapalene cream 0.1% and adapalene lotion 0.1%|Drug: adapalene lotion 0.1% Galderma Laboratories, L.P. Phase 1 2010-01-01 2012-09-21
    NCT01182636 Acne Vulgaris Drug: Adapalene|Drug: Differin|Drug: Placebo Teva Pharmaceuticals USA Phase 1 2007-07-01 2010-11-22
    NCT00647556 Photoaging Drug: adapalene gel, 0.3%|Drug: tretinoin 0.05% emollient cream Galderma Laboratories, L.P. Phase 3 2008-04-01 2012-09-21
    NCT00687908 Acne Drug: Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel|Drug: Vehicle Gel Galderma Phase 3 2008-11-01 2010-09-30
    NCT01149330 Acne Vulgaris Drug: Adapalene-BPO Gel Galderma Brasil Ltda. Phase 4 2010-07-01 2012-03-09
    NCT02932267 Acne Vulgaris Drug: Adapalene 0.3% / BPO 2.5% gel Galderma Phase 3 2016-12-01 2016-10-25
    NCT00688064 Severe Acne Vulgaris Drug: Adapalene BPO Gel associated with Doxycyline Hyclate|Drug: Vehicle Gel associated with Doxycycline Hyclate Galderma Phase 3 2008-08-01 2010-03-31
    NCT01095640 Acne Vulgaris Drug: adapalene 0.3% topical gel Actavis Mid-Atlantic LLC|Actavis Inc. 2009-03-01 2010-03-29
    NCT01209949 Acne Vulgaris Drug: Adapalene 0.1% and Benzoyl Peroxide 2.5% gel Galderma Laboratories, L.P. Phase 4 2010-10-01 2012-01-18
    NCT02721173 Acne Vulgaris Drug: Tazarotene 0.1% gel plus clindamycin 1% gel|Drug: Adapalene 0.1% gel plus clindamycin 1% gel All India Institute of Medical Sciences, Bhubaneswar Phase 4 2016-04-01 2017-01-17
    NCT01742637 Acne Vulgaris Drug: Adapalene and Benzoyl Peroxide Gel 0.1%/2.5%|Drug: Epiduo Gel|Drug: Placebo Taro Pharmaceuticals USA Phase 1 2012-10-01 2014-03-08
    NCT00660985 Acne Vulgaris Drug: Adapalene|Drug: Adapalene Galderma Phase 4 2008-05-01 2011-01-19
    NCT01951417 Acne Drug: Adapalene/BPO Gel|Other: Moisturizer SPF 30|Other: Foam Wash Galderma Laboratories, L.P. Phase 4 2013-10-01 2016-02-17
    NCT02735421 Acne Vulgaris|Atrophic Acne Scars Drug: Adapalene 0.3% / BPO 2.5% gel|Drug: Vehicle gel Galderma Phase 4 2016-05-01 2017-01-02
    NCT00807014 Acne Vulgaris Drug: Duac Gel|Drug: Differin gel Stiefel, a GSK Company|GlaxoSmithKline Phase 4 2006-11-01 2012-03-15

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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