Adapalene (阿达帕林; CD-271; Differin) 是合成的维甲酸,为维甲酸受体(RAR)激动剂。
Adapalene is a dual RAR and RXR agonist, used in the treatment of acne.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Brogden RN, et al. Drugs, 1997, 53(3), 511-519.
分子式 C28H28O3 |
分子量 412.52 |
CAS号 106685-40-9 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO >5 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01485367 | Senile Purpura | Drug: adapalene gel 0.3% | Multispecialty Aesthetic Clinical Research Organization|Galderma Laboratories, L.P. | Phase 2 | 2011-12-01 | 2012-04-19 |
NCT01213199 | Acne Scars | Drug: Adapalene | Galderma | Phase 2 | 2011-03-01 | 2015-03-09 |
NCT01406080 | Photoaging|Photodamage | Drug: Adapalene|Drug: Tretinoin | Galderma Brasil Ltda. | Phase 3 | 2013-01-01 | 2013-01-22 |
NCT00598832 | Acne Vulgaris | Drug: Adapalene lotion 0.1%|Drug: Adapalene Lotion Vehicle | Galderma | Phase 3 | 2007-11-01 | 2011-03-21 |
NCT02173054 | Acne | Other: Adapalene gel with Eucerin|Other: Adapalene gel|Other: Adapalene gel with placebo moisturizer | Mahidol University | Phase 3 | 2014-07-01 | 2016-11-28 |
NCT00599521 | Acne Vulgaris | Drug: Adapalene lotion 0.1%|Drug: Adapalene Lotion Vehicle | Galderma | Phase 3 | 2007-11-01 | 2011-03-21 |
NCT02411942 | Acne Vulgaris | Drug: Adapalene Gel 0.3%|Drug: Differin|Drug: Placebo | Taro Pharmaceuticals USA | Phase 1 | 2014-08-01 | 2015-04-07 |
NCT01046565 | Skin Manifestations | Drug: adapalene cream 0.1%|Drug: adapalene lotion 0.1% | Galderma Laboratories, L.P. | Phase 1 | 2010-01-01 | 2011-11-15 |
NCT01046396 | Skin Manifestations | Drug: adapalene cream 0.1% and adapalene lotion 0.1%|Drug: adapalene lotion 0.1% | Galderma Laboratories, L.P. | Phase 1 | 2010-01-01 | 2012-09-21 |
NCT01182636 | Acne Vulgaris | Drug: Adapalene|Drug: Differin|Drug: Placebo | Teva Pharmaceuticals USA | Phase 1 | 2007-07-01 | 2010-11-22 |
NCT00647556 | Photoaging | Drug: adapalene gel, 0.3%|Drug: tretinoin 0.05% emollient cream | Galderma Laboratories, L.P. | Phase 3 | 2008-04-01 | 2012-09-21 |
NCT00687908 | Acne | Drug: Adapalene 0.1% / Benzoyl Peroxide 2.5% Gel|Drug: Vehicle Gel | Galderma | Phase 3 | 2008-11-01 | 2010-09-30 |
NCT01149330 | Acne Vulgaris | Drug: Adapalene-BPO Gel | Galderma Brasil Ltda. | Phase 4 | 2010-07-01 | 2012-03-09 |
NCT02932267 | Acne Vulgaris | Drug: Adapalene 0.3% / BPO 2.5% gel | Galderma | Phase 3 | 2016-12-01 | 2016-10-25 |
NCT00688064 | Severe Acne Vulgaris | Drug: Adapalene BPO Gel associated with Doxycyline Hyclate|Drug: Vehicle Gel associated with Doxycycline Hyclate | Galderma | Phase 3 | 2008-08-01 | 2010-03-31 |
NCT01095640 | Acne Vulgaris | Drug: adapalene 0.3% topical gel | Actavis Mid-Atlantic LLC|Actavis Inc. | 2009-03-01 | 2010-03-29 | |
NCT01209949 | Acne Vulgaris | Drug: Adapalene 0.1% and Benzoyl Peroxide 2.5% gel | Galderma Laboratories, L.P. | Phase 4 | 2010-10-01 | 2012-01-18 |
NCT02721173 | Acne Vulgaris | Drug: Tazarotene 0.1% gel plus clindamycin 1% gel|Drug: Adapalene 0.1% gel plus clindamycin 1% gel | All India Institute of Medical Sciences, Bhubaneswar | Phase 4 | 2016-04-01 | 2017-01-17 |
NCT01742637 | Acne Vulgaris | Drug: Adapalene and Benzoyl Peroxide Gel 0.1%/2.5%|Drug: Epiduo Gel|Drug: Placebo | Taro Pharmaceuticals USA | Phase 1 | 2012-10-01 | 2014-03-08 |
NCT00660985 | Acne Vulgaris | Drug: Adapalene|Drug: Adapalene | Galderma | Phase 4 | 2008-05-01 | 2011-01-19 |
NCT01951417 | Acne | Drug: Adapalene/BPO Gel|Other: Moisturizer SPF 30|Other: Foam Wash | Galderma Laboratories, L.P. | Phase 4 | 2013-10-01 | 2016-02-17 |
NCT02735421 | Acne Vulgaris|Atrophic Acne Scars | Drug: Adapalene 0.3% / BPO 2.5% gel|Drug: Vehicle gel | Galderma | Phase 4 | 2016-05-01 | 2017-01-02 |
NCT00807014 | Acne Vulgaris | Drug: Duac Gel|Drug: Differin gel | Stiefel, a GSK Company|GlaxoSmithKline | Phase 4 | 2006-11-01 | 2012-03-15 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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