Docetaxel Trihydrate

三水多西他赛,RP 56976,RP-56976,RP56976,NSC-628503 Trihydrate,NSC628503 Trihydrate,NSC 628503 Trihydrate

Docetaxel三水合物是紫杉醇类似物,能抑制微管解聚。

目录号
EY1509
EY1509
纯度
99.59%
99.59%
规格
50 mg
100 mg
原价
280
530
售价
280
530
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Docetaxel, an analog of paclitaxel, is an inhibitor of depolymerisation of microtubules by binding to stabilized microtubules.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    6 nM

  • 动物实验

    33 mg/kgi.v. 每4天注射3次

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Buey RM. Chem Biol, 2004, 11(2), 225-236.

    分子式
    C43H59NO17
    分子量
    861.93
    CAS号
    148408-66-6
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    100 mg/mL
    Water
    <1 mg/mL
    Ethanol
    100 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01110291 CYP3A Phenotyping|CYP3A5 and MDR1 Genotyping|Docetaxel Toxicity|Associations Between Genetic Data and Docetaxel Toxicity Drug: docetaxel + CEF University of Turku|Sanofi|Turku University Hospital|Vaasa Central Hospital, Vaasa, Finland|medbase Oy Ltd 2003-04-01 2010-04-26
    NCT01019941 Advanced Solid Cancers Drug: CKD-810, Taxotere inj.|Drug: CKD-810, Taxotere inj. Chong Kun Dang Pharmaceutical Phase 1 2009-08-01 2010-12-15
    NCT00675545 Hormone-Refractory Prostate Cancer Drug: Docetaxel, Carboplatin National University Hospital, Singapore Phase 2 2007-05-01 2012-03-30
    NCT00795171 Hormone Refractory Prostate Cancer Drug: Docetaxel * Sunitinib|Drug: Docetaxel|Drug: Docetaxel Medical University of Vienna Phase 2 2008-11-01 2010-08-17
    NCT00606814 Solid Tumors Drug: IPI-504, docetaxel Infinity Pharmaceuticals, Inc. Phase 1 2007-12-01 2012-03-02
    NCT00630110 Cancer Drug: docetaxel|Drug: NPI-2358 + docetaxel Nereus Pharmaceuticals, Inc. Phase 1|Phase 2 2008-02-01 2011-08-15
    NCT00714376 Prostate Cancer Drug: Docetaxel Centre Hospitalier Universitaire de Qubec, CHU de Qubec Phase 2 2008-05-01 2012-10-30
    NCT01949519 Adenocarcinoma of the Prostate Drug: Lycopene and Docetaxel Medical University of South Carolina|National Cancer Institute (NCI) Phase 1 2013-11-01 2016-10-18
    NCT01254513 Prostate Cancer Drug: Docetaxel every 3 weeks + Prednisone|Drug: Docetaxel weekly+ Prednisone UNICANCER Phase 2 2010-11-01 2013-01-29
    NCT00703378 Solid Tumors Drug: Docetaxel (Taxotere) National University Hospital, Singapore Phase 1|Phase 2 2006-05-01 2012-03-27
    NCT01837667 Tumors|Neoplasms|Cancer Drug: LB-100 for Injection|Drug: Docetaxel Lixte Biotechnology Holdings, Inc. Phase 1 2013-02-01 2017-01-23
    NCT00248703 Breast Cancer Drug: Docetaxel Oslo University Hospital|University of Tromso|Helse Stavanger HF|Sorlandet Hospital HF|Sykehuset Innlandet HF|Ullevaal University Hospital|Sykehuset i Vestfold HF|Sykehuset Ostfold|Alesund Hospital Phase 2 2003-10-01 2012-11-20
    NCT01256359 Melanoma Drug: Docetaxel and AZD6244|Drug: Docetaxel and placebo University of Oxford Phase 2 2010-10-01 2016-06-21
    NCT02274610 Solid Tumor Drug: Docetaxel-PNP|Drug: Taxotere Samyang Biopharmaceuticals Corporation Phase 1 2014-11-01 2014-10-23
    NCT00169000 Metastatic Breast Cancer Drug: Capecitabine|Drug: Docetaxel Dartmouth-Hitchcock Medical Center|Hoffmann-La Roche Phase 1 2003-01-01 2009-08-04
    NCT00030407 Lung Cancer Drug: Celecoxib|Drug: Docetaxel Barbara Ann Karmanos Cancer Institute|National Cancer Institute (NCI) Phase 2 2001-10-01 2013-04-25
    NCT00582634 Non Small Cell Lung Cancer Drug: docetaxel and cisplatin University of Wisconsin, Madison Phase 2 2004-09-01 2015-09-30
    NCT00080665 Breast Cancer Drug: docetaxel|Drug: imatinib mesylate Sidney Kimmel Comprehensive Cancer Center|National Cancer Institute (NCI) Phase 1 2003-12-01 2016-11-04
    NCT01336582 Solid Tumor Drug: taxotere Samyang Biopharmaceuticals Corporation Phase 1 2009-08-01 2012-12-19
    NCT01693432 Esophageal Neoplasms Drug: DS (docetaxel+S-1) Hallym University Medical Center|Jeil Pharmaceutical Co., Ltd. Phase 2 2011-11-01 2016-09-27

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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