Dopamine HCl

盐酸多巴胺

Dopamine hydrochloride 是多巴胺D1-5受体激动剂,是广泛存在于多种动物中的儿茶酚胺神经递质。

目录号
EY1491
EY1491
纯度
99.64%
99.64%
规格
50 mg
100 mg
原价
200
300
售价
200
300
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Yasunari, K., et al. 1994. Am. J. Physiol. 267: R628-R634. PMID: 8092305
    [2] Shashoua, V.E., et al. 1996. Life Sci. 58: 1347-1357. PMID: 8614292
    [3] Malek, D., et al. 1993. FEBS Lett. 325: 215-219. PMID: 8319806

    分子式
    C8H12ClNO2
    分子量
    189.64
    CAS号
    62-31-7
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    38 mg/mL
    Water
    38 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01318278 Hypotension Drug: Dopamine|Drug: Arginine Vasopressin Baylor College of Medicine|Thrasher Research Fund 2011-03-01 2015-02-24
    NCT02053935 Hyperglycemia|Sepsis Drug: Dopamine Albert Einstein College of Medicine, Inc. Phase 1 2013-12-01 2016-08-05
    NCT01427686 Arterial Hypotension Drug: Dobutamine|Drug: Dopamine University of Ulm Phase 4 2011-06-01 2016-04-05
    NCT01780467 Parkinson's Disease Behavioral: Role of dopamine University Hospital, Clermont-Ferrand Phase 4 2013-03-01 2013-01-29
    NCT00604019 Septic Shock Drug: Dopamine|Drug: Norepinephrine Rush University Medical Center Phase 3 2003-03-01 2013-02-26
    NCT00115115 Kidney Transplantation|ESRD Drug: Dopamine infusion to brain dead organ donors Universittsmedizin Mannheim|Eurotransplant International Foundation, Leiden, The Netherlands|Regional Organ Procurement Organization (DSO), Baden-Wuerttemberg, Germany|Regional Organ Procurement Organization (DSO), Bavaria, Germany|Novartis Phase 4 2004-03-01 2009-04-22
    NCT00038116 Parkinson Disease Procedure: embryonic dopamine cell implant surgery|Procedure: placebo University of Colorado, Denver Phase 3 1995-05-01 2013-02-04
    NCT02402101 Transcranial Direct Current Stimulation|Dopamine Device: Procedure: active tDCS|Device: Procedure: sham tDCS Hpital le Vinatier Phase 3 2015-02-01 2016-08-22
    NCT00937092 Acute Heart Failure Drug: Furosemide|Drug: low-dose dopamine + low-dose furosemide Larissa University Hospital Phase 4 2009-01-01 2010-05-25
    NCT03059563 Dopamine D2/3 Receptor Availability|Cognitive Function|Methamphetamine Abuse Drug: Varenicline|Other: Placebo University of California, Los Angeles|Tarzana Treatment Center Phase 1 2017-04-01 2017-02-16
    NCT00396669 Tobacco Use Disorder Drug: Bupropion|Drug: Bupropion Hadassah Medical Organization 2007-07-01 2012-03-26
    NCT01901809 Heart Failure, Diastolic Drug: Furosemide|Drug: Dopamine Johns Hopkins University Phase 4 2013-08-01 2017-03-07
    NCT02201121 Circulation|Drug Dose|Calculated SAP Other: Influences of phenylephrine, dopamine and ephedrine on stroke volume variation and pulse pressure variation Chinese PLA General Hospital 2014-03-01 2014-07-24
    NCT00942253 Restless Legs Syndrome|End Stage Renal Disease|Hemodialysis|Muscle Cachexia|Sleep Disorders Other: Dopamine Agonist and Exercise University of Thessaly|Center for Research and Technology Thessaly - CERETETH|European Social Fund Phase 2 2006-09-01 2010-07-02
    NCT01060293 Acute Decompensated Heart Failure Drug: High-dose furosemide|Drug: Low-dose furosemide|Drug: Low-dose furosemide combined with low-dose dopamine Larissa University Hospital Phase 4 2009-07-01 2013-09-10
    NCT00670293 Eating Disorders Radiation: Positron Emission Tomography (PET) using [11C]raclopride|Drug: Methylphenidate|Procedure: Magnetic Resonance Imaging (MRI) scan New York State Psychiatric Institute|National Institute of Mental Health (NIMH) 2008-07-01 2016-04-06
    NCT01906411 Adiposity|Weight Loss Dietary Supplement: Dopamine depletion vs. Balanced aminoacid drink University Hospital Tuebingen 2015-05-28
    NCT02148783 Traumatic Brain Injury Drug: methylphenidate|Drug: Placebo Uniformed Services University of the Health Sciences|National Institutes of Health (NIH) Phase 2 2014-09-01 2014-05-27
    NCT02347059 Parkinson's Disease Drug: L-dopa|Drug: Dopamine Agonists (pramipexole, ropirinole) University of Toronto|Michael J. Fox Foundation for Parkinson's Research Phase 2 2015-01-01 2015-01-26
    NCT01365364 Periodic Limb Movements in Sleep Behavioral: Aerobic Physical Exercise|Behavioral: Aerobic Physical Exercise Federal University of So Paulo|Fundao de Amparo Pesquisa do Estado de So Paulo|Associao Fundo de Incentivo Pesquisa 2009-03-01 2011-06-02
    NCT01722630 Intra Operative Fluid Management Drug: Dopamine Catholic University of the Sacred Heart 2012-03-01 2012-11-05
    NCT00314704 Shock Drug: dopamine versus norepinephrine Sepsis Occurrence in Acutely Ill Patients Phase 3 2003-12-01 2010-01-29
    NCT01264861 Parkinson Disease Drug: Safinamide Newron Phase 2 2010-12-01 2013-03-28
    NCT00940914 Parkinson's Disease|Pain Drug: ioflupane 123I (DATSCAN) University Hospital, Toulouse Phase 2 2009-03-01 2011-03-29
    NCT01160263 Amyotrophic Lateral Sclerosis Drug: SPECT : 123 I-FP-CIT (DATSCAN) and 123I-ADAM Assistance Publique - Hpitaux de Paris|Association Franaise contre les Myopathies (AFM), Paris|ARS (Association pour la Recherche sur la Sclrose Latrale Amyotrophique)|Agence Gnrale des Equipements et Produits de Sant Phase 3 2012-10-01 2015-05-12

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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