Dopamine hydrochloride 是多巴胺D1-5受体激动剂,是广泛存在于多种动物中的儿茶酚胺神经递质。
Dopamine HCl is a catecholamine neurotransmitter present in a wide variety of animals,And a dopamine D1-5 receptors agonist.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Yasunari, K., et al. 1994. Am. J. Physiol. 267: R628-R634. PMID: 8092305
[2] Shashoua, V.E., et al. 1996. Life Sci. 58: 1347-1357. PMID: 8614292
[3] Malek, D., et al. 1993. FEBS Lett. 325: 215-219. PMID: 8319806
分子式 C8H12ClNO2 |
分子量 189.64 |
CAS号 62-31-7 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 38 mg/mL |
Water 38 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01318278 | Hypotension | Drug: Dopamine|Drug: Arginine Vasopressin | Baylor College of Medicine|Thrasher Research Fund | 2011-03-01 | 2015-02-24 | |
NCT02053935 | Hyperglycemia|Sepsis | Drug: Dopamine | Albert Einstein College of Medicine, Inc. | Phase 1 | 2013-12-01 | 2016-08-05 |
NCT01427686 | Arterial Hypotension | Drug: Dobutamine|Drug: Dopamine | University of Ulm | Phase 4 | 2011-06-01 | 2016-04-05 |
NCT01780467 | Parkinson's Disease | Behavioral: Role of dopamine | University Hospital, Clermont-Ferrand | Phase 4 | 2013-03-01 | 2013-01-29 |
NCT00604019 | Septic Shock | Drug: Dopamine|Drug: Norepinephrine | Rush University Medical Center | Phase 3 | 2003-03-01 | 2013-02-26 |
NCT00115115 | Kidney Transplantation|ESRD | Drug: Dopamine infusion to brain dead organ donors | Universittsmedizin Mannheim|Eurotransplant International Foundation, Leiden, The Netherlands|Regional Organ Procurement Organization (DSO), Baden-Wuerttemberg, Germany|Regional Organ Procurement Organization (DSO), Bavaria, Germany|Novartis | Phase 4 | 2004-03-01 | 2009-04-22 |
NCT00038116 | Parkinson Disease | Procedure: embryonic dopamine cell implant surgery|Procedure: placebo | University of Colorado, Denver | Phase 3 | 1995-05-01 | 2013-02-04 |
NCT02402101 | Transcranial Direct Current Stimulation|Dopamine | Device: Procedure: active tDCS|Device: Procedure: sham tDCS | Hpital le Vinatier | Phase 3 | 2015-02-01 | 2016-08-22 |
NCT00937092 | Acute Heart Failure | Drug: Furosemide|Drug: low-dose dopamine + low-dose furosemide | Larissa University Hospital | Phase 4 | 2009-01-01 | 2010-05-25 |
NCT03059563 | Dopamine D2/3 Receptor Availability|Cognitive Function|Methamphetamine Abuse | Drug: Varenicline|Other: Placebo | University of California, Los Angeles|Tarzana Treatment Center | Phase 1 | 2017-04-01 | 2017-02-16 |
NCT00396669 | Tobacco Use Disorder | Drug: Bupropion|Drug: Bupropion | Hadassah Medical Organization | 2007-07-01 | 2012-03-26 | |
NCT01901809 | Heart Failure, Diastolic | Drug: Furosemide|Drug: Dopamine | Johns Hopkins University | Phase 4 | 2013-08-01 | 2017-03-07 |
NCT02201121 | Circulation|Drug Dose|Calculated SAP | Other: Influences of phenylephrine, dopamine and ephedrine on stroke volume variation and pulse pressure variation | Chinese PLA General Hospital | 2014-03-01 | 2014-07-24 | |
NCT00942253 | Restless Legs Syndrome|End Stage Renal Disease|Hemodialysis|Muscle Cachexia|Sleep Disorders | Other: Dopamine Agonist and Exercise | University of Thessaly|Center for Research and Technology Thessaly - CERETETH|European Social Fund | Phase 2 | 2006-09-01 | 2010-07-02 |
NCT01060293 | Acute Decompensated Heart Failure | Drug: High-dose furosemide|Drug: Low-dose furosemide|Drug: Low-dose furosemide combined with low-dose dopamine | Larissa University Hospital | Phase 4 | 2009-07-01 | 2013-09-10 |
NCT00670293 | Eating Disorders | Radiation: Positron Emission Tomography (PET) using [11C]raclopride|Drug: Methylphenidate|Procedure: Magnetic Resonance Imaging (MRI) scan | New York State Psychiatric Institute|National Institute of Mental Health (NIMH) | 2008-07-01 | 2016-04-06 | |
NCT01906411 | Adiposity|Weight Loss | Dietary Supplement: Dopamine depletion vs. Balanced aminoacid drink | University Hospital Tuebingen | 2015-05-28 | ||
NCT02148783 | Traumatic Brain Injury | Drug: methylphenidate|Drug: Placebo | Uniformed Services University of the Health Sciences|National Institutes of Health (NIH) | Phase 2 | 2014-09-01 | 2014-05-27 |
NCT02347059 | Parkinson's Disease | Drug: L-dopa|Drug: Dopamine Agonists (pramipexole, ropirinole) | University of Toronto|Michael J. Fox Foundation for Parkinson's Research | Phase 2 | 2015-01-01 | 2015-01-26 |
NCT01365364 | Periodic Limb Movements in Sleep | Behavioral: Aerobic Physical Exercise|Behavioral: Aerobic Physical Exercise | Federal University of So Paulo|Fundao de Amparo Pesquisa do Estado de So Paulo|Associao Fundo de Incentivo Pesquisa | 2009-03-01 | 2011-06-02 | |
NCT01722630 | Intra Operative Fluid Management | Drug: Dopamine | Catholic University of the Sacred Heart | 2012-03-01 | 2012-11-05 | |
NCT00314704 | Shock | Drug: dopamine versus norepinephrine | Sepsis Occurrence in Acutely Ill Patients | Phase 3 | 2003-12-01 | 2010-01-29 |
NCT01264861 | Parkinson Disease | Drug: Safinamide | Newron | Phase 2 | 2010-12-01 | 2013-03-28 |
NCT00940914 | Parkinson's Disease|Pain | Drug: ioflupane 123I (DATSCAN) | University Hospital, Toulouse | Phase 2 | 2009-03-01 | 2011-03-29 |
NCT01160263 | Amyotrophic Lateral Sclerosis | Drug: SPECT : 123 I-FP-CIT (DATSCAN) and 123I-ADAM | Assistance Publique - Hpitaux de Paris|Association Franaise contre les Myopathies (AFM), Paris|ARS (Association pour la Recherche sur la Sclrose Latrale Amyotrophique)|Agence Gnrale des Equipements et Produits de Sant | Phase 3 | 2012-10-01 | 2015-05-12 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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