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Metformin HCl

盐酸二甲双胍

Metformin HCl 是一种双胍类降糖药，用于治疗对饮食调整没有反应的非胰岛素依赖型糖尿病。

目录号
EY1488
EY1488
纯度
99.22%
99.22%
规格
10 mg
50 mg
原价
180
350
售价
180
350
库存
现货
现货
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  • 生物活性

    Metformin HCl is one of the most effective and widely used therapeutics for treatment of type 2 diabetes. It selectively lowers the hepatic gluconeogenesis without rising insulin production, causing weight gain or hypoglycemia.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Zhou G, et al. J Clin Invest, 2001, 108(8), 1167-1174.

    分子式
    C4H11N5.HCl    		 分子量
    165.62    		 CAS号
    1115-70-4    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    33 mg/mL    		 Water
    33 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00187798 Other Conditions That May Be A Focus of Clinical Attention Drug: Metformin HCl University of California, San Francisco 2001-08-01 2012-09-24
    NCT02978547 Resectable Pancreatic Ductal Adenocarcinoma Drug: Metformin Hydrochloride 500Mg Tablet British Columbia Cancer Agency|Pancreatic Cancer Canada|BC Cancer Foundation Phase 2 2017-01-01 2016-11-28
    NCT02670018 Healthy Drug: gemigliptin and metformin HCl extended release|Drug: gemigliptin/metformin HCl extended release LG Life Sciences Phase 1 2015-08-01 2016-01-31
    NCT01595880 Healthy Drug: gemigliptin and metformin HCl extended release|Drug: gemigliptin/metformin HCl extended release LG Life Sciences Phase 1 2014-12-01 2015-02-02
    NCT01662674 Healthy Drug: gemigliptin and metformin HCl extended release|Drug: gemigliptin/metformin HCl extended release LG Life Sciences Phase 1 2012-10-01 2015-04-02
    NCT02056600 Healthy Drug: gemigliptin and metformin HCl extended release|Drug: gemigliptin/metformin HCl sustained release LG Life Sciences Phase 1 2014-03-01 2014-05-07
    NCT02972723 Chronic Hepatitis C Infection Drug: Metformin Nottingham University Hospitals NHS Trust Phase 4 2011-03-01 2016-11-22
    NCT02684578 Age-Related Macular Degeneration|Macular Degeneration, Age-Related|Dry Macular Degeneration|Geographic Atrophy Drug: Metformin University of California, San Francisco|Northwestern University|University of California, Irvine|University of California, Davis|San Francisco Veterans Affairs Medical Center|Retinal Consultants of Arizona Phase 2 2016-04-01 2017-02-02
    NCT01357148 Diabetes Mellitus, Type 2 Drug: Sitagliptin Phosphate/Metformin HCl (JANUMET) Merck Sharp & Dohme Corp. 2009-03-01 2015-08-07
    NCT00865072 Healthy Drug: Metformin HCl 750 mg Extender Release tablets, single dose|Drug: GLUCOPHAGE XR 750 mg tablets, single dose Actavis Inc. Phase 1 2003-08-01 2010-08-13
    NCT00865852 Healthy Drug: Metformin HCl 750 mg Extender Release tablets, single dose|Drug: GLUCOPHAGE XR 750 mg tablets, single dose Actavis Inc. Phase 1 2003-08-01 2010-08-13
    NCT01997775 Non-small Cell Lung Cancer Drug: METFORMIN National Cheng-Kung University Hospital Phase 2 2013-08-01 2016-09-29
    NCT02086526 Polycystic Ovary Syndrome Drug: Metformin Mayo Clinic Phase 1|Phase 2 2014-03-01 2016-05-19
    NCT02496741 Glioma|Cholangiocarcinoma|Chondrosarcoma Drug: Metformin and chloroquine combination Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) Phase 1|Phase 2 2015-11-01 2015-11-14
    NCT01486043 Acute Lymphoblastic Leukemia|Hyperglycemia|Insulin Resistance|Diabetes Mellitus Drug: Metformin Children's Hospital Los Angeles 2011-12-01 2015-01-20
    NCT01747083 Type 2 Diabetes Drug: FDC(gemigliptin/metformin HCl sustained release 50/1000mg(25/500mg x 2tablets)) LG Life Sciences Phase 1 2013-01-01 2013-10-22
    NCT00570739 Type 2 Diabetes Mellitus|Hypercholesterolemia|Pre-diabetes Drug: Metformin HCl and Colesevelam Placebo|Drug: Metformin HCl tablets and Colesevelam tablets|Drug: Colesevelam placebo|Drug: Colesevelam Daiichi Sankyo Inc. Phase 3 2007-11-01 2010-07-19
    NCT01266486 Breast Cancer Drug: Metformin Oxford University Hospitals NHS Trust|Cancer Research UK Phase 2 2011-05-01 2014-07-01
    NCT02354027 Type 2 Diabetes Drug: SHR3824 metformin Jiangsu HengRui Medicine Co., Ltd. Phase 1 2014-09-01 2015-07-14
    NCT00865748 Healthy Drug: Metformin HCl 500 mg tablets, single dose|Drug: CLUCOPHAGEXR 500 mg tablets, single dose Actavis Inc. Phase 1 2004-01-01 2010-08-13
    NCT00865839 Healthy Drug: Metformin HCl 500 mg tablets, single dose|Drug: CLUCOPHAGEXR 500 mg tablets, single dose Actavis Inc. Phase 1 2002-03-01 2010-08-13
    NCT00864669 Healthy Drug: Metformin HCl 500 mg tablets, single dose|Drug: CLUCOPHAGEXR 500 mg tablets, single dose Actavis Inc. Phase 1 2002-03-01 2010-08-13
    NCT01873859 Diabetes Mellitus|Lactic Acidosis Drug: Metformin Shahid Beheshti University of Medical Sciences 2013-05-01 2014-05-16
    NCT03086005 Polycystic Ovary Syndrome Drug: Metformin Chung-Hoon Kim|Asan Medical Center 2011-10-12 2017-03-15
    NCT03017833 Solid Tumor|Advanced Cancer Drug: Metformin|Drug: TAK-228 M.D. Anderson Cancer Center|Takeda Pharmaceuticals International, Inc. Phase 1 2017-06-01 2017-03-17
    NCT01409395 Healthy Drug: Metformin and nizatidine|Drug: Metformin University of California, San Francisco|National Institute of General Medical Sciences (NIGMS) Phase 1 2011-09-01 2014-04-09
    NCT01884558 Pharmacokinetics of Isavuconazole|Pharmacokinetics of Metformin|Healthy Subjects Drug: isavuconazole|Drug: metformin Astellas Pharma Global Development, Inc.|Basilea Pharmaceutica International Ltd|Astellas Pharma Inc Phase 1 2013-02-01 2013-06-20
    NCT01561482 Prostate Carcinoma Drug: Metformin|Drug: Simvastatin Nicholas Mitsiades|Baylor College of Medicine Phase 2 2012-01-01 2015-07-20
    NCT02895750 Renal Insufficiency, Chronic Drug: Metformin Centre Hospitalier Universitaire, Amiens Phase 2 2016-09-01 2016-09-06
    NCT01681680 Healthy Drug: Metformin University of California, San Francisco Phase 1 2010-10-01 2014-06-30
    NCT01422746 Obesity|Hyperandrogenemia|Polycystic Ovary Syndrome Drug: Metformin University of Virginia 2016-12-01 2016-12-16
    NCT01334684 Type 2 Diabetes Drug: Metformin Casa Sollievo della Sofferenza IRCCS|University Hospital, Catania 2011-05-01 2011-04-12
    NCT01613755 Diabetes Drug: Metformin, dipyridamole|Drug: Metformin Radboud University Phase 4 2012-04-01 2013-04-26

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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