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Lidocaine

利多卡因,赛罗卡因,昔罗卡因,Alphacaine

Lidocaine是组胺H1受体反向激动剂，IC50>32 μM。

目录号
EY1482
EY1482
纯度
99.22%
99.22%
规格
10 mg
50 mg
原价
290
632
售价
290
632
库存
现货
现货
订购
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  • 生物活性

    Lidocaine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Sarraf et al (2003) Tedisamil and lidocaine enhance each other's antiarrhythmic activity against ischaemia-induced arrhythmias in rats. Br.J.Pharmacol. 139 1389.
    [2] Jason S. Bant,et al. Antagonism of Lidocaine Inhibition by Open-Channel Blockers That Generate Resurgent Na Current. J Neurosci. Author manuscript; available in PMC 2013 Sep 13. Published in final edited form as: J Neurosci. 2013 Mar 13; 33(11): 4976–4987. doi: 10.1523/JNEUROSCI.3026-12.2013
    [3] Patrick L Sheets,et al. Lidocaine reduces the transition to slow inactivation in Nav1.7 voltage-gated sodium channels. Br J Pharmacol. 2011 Sep; 164(2b): 719–730. doi: 10.1111/j.1476-5381.2011.01209.x.

    分子式
    C14H22N2O    		 分子量
    234.34    		 CAS号
    137-58-6    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    45 mg/mL    		 Water
    10 mg/mL    		 Ethanol
    50 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02620683 Blood Levels of Buffered vs Non-buffered Lidocaine|Anesthetics, Local Drug: Lidocaine University of North Carolina, Chapel Hill|Dental Foundation of North Carolina, Inc. 2015-12-01 2016-09-20
    NCT02241096 Colorectal Surgery Drug: Lidocaine Children's Hospital Medical Center, Cincinnati Phase 1 2015-01-01 2016-08-26
    NCT02219321 Chronic Pain Drug: Lidocaine infusion|Drug: Saline infusion University of Texas Southwestern Medical Center Phase 3 2014-12-01 2016-11-09
    NCT00986505 Fibromyalgia Drug: Lidocaine Federal University of So Paulo 2005-02-01 2009-09-29
    NCT03030560 Postoperative Pain Drug: Lidocaine|Drug: 0.9% Sodium-chloride Abdelrady S Ibrahim, MD|Assiut University Phase 2 2015-04-01 2017-02-10
    NCT01314300 Neuropathic Pains|Vasoocclusive Sickle Cell Crises Pains Drug: Lidocaine Centre Leon Berard Phase 2 2011-03-01 2014-10-29
    NCT02574832 Pregnancy|Surgery|Pain Drug: Lidocaine Administration Northwestern University 2015-10-01 2016-08-30
    NCT00977028 Anesthesia Drug: Tumescent Local Anesthesia (lidocaine, epinephrine)|Procedure: Liposuction Klein, Jeffrey A., M.D. Phase 1|Phase 2 2005-01-01 2011-06-14
    NCT00965796 Pain Intensity Drug: Lidocaine Federal University of So Paulo 2008-05-01 2009-08-25
    NCT00651313 Dysmenorrhea Drug: Lidocaine|Drug: Placebo Juniper Pharmaceuticals, Inc. Phase 2 2007-08-01 2012-02-16
    NCT00594542 Anesthesia Drug: lidocaine University of Pennsylvania 2007-06-01 2008-01-03
    NCT02525016 Obesity|Bariatric Surgery Biological: Blood sampling|Drug: Lidocaine Hospices Civils de Lyon Phase 3 2015-09-01 2016-03-14
    NCT02192411 Pain During and After Endovenous Laser Obliteration of Large Saphenous Vein Based on Lidocaine Tumescent Concentration Drug: Lidocaine Midwest Vein Center 2014-07-01 2014-07-15
    NCT00693043 Pain Drug: lidocaine hydrochloride Lahey Clinic 2008-02-01 2014-03-26
    NCT02924480 Invasive Bladder Cancer Procedure: Cystectomy|Drug: Lidocaine|Drug: Saline CAMC Health System 2016-08-01 2016-10-04
    NCT02983682 Pain, Chronic Drug: Lidocaine Infusion The Hospital for Sick Children Phase 3 2016-12-01 2016-12-05
    NCT01780324 Pediatric Presentation of Urinary Tract Infection Drug: Lidocaine Seattle Children's Hospital 2013-01-01 2016-03-28
    NCT00991848 Fibromyalgia|Chronic Pain Drug: Lidocaine Federal University of So Paulo Phase 1 2005-01-01 2009-10-08
    NCT01252225 Chronic Cough Drug: 10 % Lidocaine|Drug: 10 % Lidocaine|Drug: 0.9% saline University Hospital of South Manchester NHS Foundation Trust Phase 4 2011-02-01 2011-09-15
    NCT02287870 Anesthesia Drug: Chloroprocaine|Drug: Lidocaine Jinling Hospital, China Phase 4 2008-01-01 2014-11-10

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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