Menadione是合成的萘醌,可在体内转化为活性维生素K2。
Menadione shows vitamin K activity, used as a nutritional supplement.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Gerasimenko JV, et al. J Cell Sci,?002, 115(Pt 3), 485-497.
分子式 C11H8O2 |
分子量 172.18 |
CAS号 58-27-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 35 mg/mL |
Water <1 mg/mL |
Ethanol 35 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02876354 | Vascular Calcifications | Drug: Menaquinone | Saint-Joseph University | Phase 4 | 2016-08-01 | 2016-09-18 |
NCT00336232 | Aging|Osteoporosis | Drug: Vitamin K | Tufts University | 2006-05-01 | 2016-04-22 | |
NCT00931437 | Healthy | Dietary Supplement: vitamin K-rich dairy product | Maastricht University Medical Center | 2009-04-01 | 2010-12-15 | |
NCT01094444 | Folliculitis | Other: Vitamin K3 | Per Pfeiffer|Odense University Hospital | Phase 2 | 2010-05-01 | 2015-01-20 |
NCT00656786 | EGFR Inhibitor-associated Rash | Drug: Menadione Topical Lotion|Drug: Menadione Topical Lotion | Spectrum Pharmaceuticals, Inc | Phase 1 | 2008-04-01 | 2015-06-02 |
NCT01143831 | Thrombosis | Dietary Supplement: Vitamin K, 20mg | Stephan Moll, MD|University of North Carolina, Chapel Hill | 2009-11-01 | 2012-06-11 | |
NCT00785109 | Aortic Valve Calcification | Dietary Supplement: Vitamin K supplementation | RWTH Aachen University | Phase 2|Phase 3 | 2010-01-01 | 2015-09-22 |
NCT01742273 | Cardiovascular Diseases | Drug: Vitamin K1 | RWTH Aachen University | Phase 3 | 2013-10-01 | 2015-09-21 |
NCT01533441 | Thrombosis | Dietary Supplement: Vitamin K2 | Danisco | Phase 2 | 2012-02-01 | 2014-04-07 |
NCT02324686 | End Stage Renal Failure on Dialysis|Atrial Fibrillation | Drug: vitamin K1 | University Health Network, Toronto | Phase 2 | 2014-01-01 | 2016-05-10 |
NCT01972113 | Obesity|Insulin Resistance|Insulin Sensitivity|Prediabetes|Dyslipidemia|Diabetes | Dietary Supplement: Placebo-Control|Dietary Supplement: Low-Dose Vitamin K2 (menaquinone-7; 45 mcg/d)|Dietary Supplement: High-Dose Vitamin K2 (menaquinone-7; 90 mcg/d) | Augusta University|University of Alabama at Birmingham|Yale University|Tufts University|Nattopharma ASA | Phase 1|Phase 2 | 2013-09-01 | 2016-10-11 |
NCT02959762 | Obesity|Insulin Resistance|Obesity in Diabetes|Nutritional and Metabolic Diseases|Hyperlipidemia|Hyperglycemia|Cardiovascular Diseases | Dietary Supplement: Placebo-Control|Dietary Supplement: Low-Dose Vitamin K2 (menaquinone-7; 45-mcg/d)|Dietary Supplement: High-Dose Vitamin K2 (menaquinone-7; 90 mcg/d) | Augusta University | Phase 1|Phase 2 | 2016-10-01 | 2016-11-07 |
NCT01393821 | Dermatologic Complications|Malignant Neoplasm|Pain | Drug: menadione topical lotion|Other: placebo|Other: questionnaire administration|Procedure: management of therapy complications | Mayo Clinic | 2012-01-01 | 2017-03-21 | |
NCT00990158 | Coagulation|Bleeding|Thrombosis | Drug: Phytonadione (Vitamin K1)|Drug: Placebo | St. Joseph's Healthcare Hamilton|McMaster University|University of Western Ontario, Canada | Phase 3 | 2010-07-01 | 2015-05-19 |
NCT02517580 | Arterial Stiffness|Vitamin K2 Deficiency | Dietary Supplement: Vitamin K2 (MK7) | Lebanese American University|Omicron Pharmaceuticals | Phase 2 | 2015-03-01 | 2016-06-06 |
NCT01675206 | Vascular Calcification | Dietary Supplement: Vitamin K2 supplementation | Rogier Caluwe|Onze Lieve Vrouw Hospital | Phase 3 | 2011-05-01 | 2012-08-25 |
NCT01232647 | Post-Menopausal Osteoporosis | Drug: Phylloquinone|Drug: Menaquinone (MK4)|Drug: placebo | Guy's and St Thomas' NHS Foundation Trust | Phase 2|Phase 3 | 2011-04-01 | 2010-11-01 |
NCT02278692 | Calciphylaxis|Calcific Uremic Arteriolopathy | Dietary Supplement: Vitamin K|Other: Placebo | Massachusetts General Hospital|National Kidney Foundation | 2015-03-01 | 2017-01-25 | |
NCT02505282 | Orthostatic Hypotension | Other: Vitamin K status | University of Dundee|British Geriatrics Society | 2012-04-01 | 2015-07-23 | |
NCT00642551 | Bone Loss|Arteriosclerosis | Dietary Supplement: menaquinone-7|Dietary Supplement: placebo | Maastricht University Medical Center | 2008-03-01 | 2012-06-11 | |
NCT02870829 | Vascular Calcification|Systemic and Arterial Stiffness|Complication of Hemodialysis|Deficiency of Vitamin K2 | Drug: menaquinone-7 | National University Health System, Singapore|National Medical Research Council (NMRC), Singapore|Nattopharma ASA | Phase 2 | 2016-07-01 | 2016-08-16 |
NCT01528800 | Endstage Kidney Disease | Drug: Vitamin K1|Drug: Chrystalline Lactose | Dr. Rachel Holden|Kingston General Hospital|Clinical Evaluation Research Unit at Kingston General Hospital | Phase 2 | 2012-11-01 | 2016-07-25 |
NCT01101698 | Kidney Diseases|Coronary Artery Calcification | Drug: Vitamin K2+10g cholecalciferol|Drug: Vitamin D | Medical Universtity of Lodz | Phase 4 | 2009-06-01 | 2010-04-12 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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