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Gallamine Triethiodide

加拉碘铵

Gallamine Triethiodide是胆碱能受体抑制剂和非去极化阻断剂，IC50为68.0±8.4 μM。

目录号
EY1464
EY1464
纯度
99.23%
99.23%
规格
100 mg
500 mg
原价
480
1300
售价
480
1300
库存
现货
现货
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  • 生物活性

    Gallamine Triethiodide is a cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 μM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Phedias Diamandis et. Al. Chemical genetics reveals a complex functional ground state of neural stem cells. Nature Chemical Biology, 3(5), 268-273 (2007).
    [2] Tjitske A Oenema et. Al. Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). American Journal of Respiratory Cell and Molecular Biology, 49(1), 18-27 (2013).
    [3] R A Leppik et. Al. Role of acidic amino acids in the allosteric modulation by gallamine of antagonist binding at the m2 muscarinic acetylcholine receptor. Molecular Pharmacology, 45(5), 983-990 (1994).

    分子式
    C30H60I3N3O3    		 分子量
    891.53    		 CAS号
    65-29-2    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    100 mg/mL    		 Water
    100 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01619280 Acute Lung Injury|Acute Respiratory Distress Syndrome|Sodium Nitroprusside|Hypoxia|Respiratory Failure Drug: Sodium Nitroprusside Mount Sinai Hospital, Canada Phase 1 2012-05-01 2012-06-12
    NCT00135668 Hypotension Drug: nitroprusside Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)|Stanford University|Duke University Phase 2 2005-08-01 2009-05-26
    NCT00621816 Hypertension Drug: nitroprusside|Drug: placebo infusion Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Phase 2 2009-01-01 2011-12-02
    NCT00636584 Nitroprusside|Thyroid Hormones Drug: sodium nitroprusside|Drug: placebo Kavakldere Umut Hospital|Ankara University Phase 4 2008-02-01 2008-03-07
    NCT02164981 Schizophrenia Drug: sodium nitroprusside|Other: Placebo Massachusetts General Hospital Phase 2 2015-05-01 2016-09-21
    NCT01548612 Schizophrenia Drug: Sodium nitroprusside|Drug: Glucose solution University of Sao Paulo Phase 2 2006-02-01 2012-03-07
    NCT01248091 Cervical Pain|Pelvic Pain Procedure: Nitroprusside Gel|Procedure: Placebo Gel Oregon Health and Science University|Society of Family Planning 2010-12-01 2012-09-12
    NCT02001298 Hypotension, Controlled Drug: remifentanil|Drug: nitroprusside Jeju National University School of Medicine 2012-06-01 2013-12-03
    NCT00093912 Hypertension Drug: clevidipine|Drug: sodium nitroprusside The Medicines Company Phase 3 2004-06-01 2014-05-05
    NCT01747174 ST-elevation Myocardial Infarction (STEMI) Drug: IC Adenosine|Drug: IC Sodium nitroprusside (SNP)|Procedure: Standard PCI University Hospitals, Leicester Phase 2 2011-10-01 2015-06-15
    NCT00128791 Myocardial Infarction Drug: Nitroprusside Soroka University Medical Center Phase 4 2003-01-01 2007-05-24
    NCT02176044 Schizophrenia Drug: Sodium Nitroprusside infusion|Other: Placebo King's College London Phase 1 2014-08-01 2016-03-08
    NCT00945256 Aging Other: Aerobic Exercise|Drug: Sodium Nitroprusside|Dietary Supplement: Amino Acid Drink The University of Texas Medical Branch, Galveston|National Institute on Aging (NIA) Phase 1 2003-05-01 2016-01-05
    NCT00590070 Myocardial Infarction Drug: adenosine|Drug: nitroprusside|Drug: placebo Catholic University of the Sacred Heart Phase 2|Phase 3 2008-01-01 2012-03-25
    NCT02085317 Lepromatous Leprosy Drug: acetylcholine Iontophoresis|Drug: sodium nitroprusside Iontophoresis Curt Treu|Rio de Janeiro State University 2006-03-01 2014-03-10
    NCT00901888 Heart Disease|Vasodilation Drug: Apelin infusion|Drug: Sodium nitroprusside infusion University of Edinburgh|NHS Lothian 2009-04-01 2010-08-09
    NCT02767024 Acute Heart Failure Drug: Sodium nitroprusside|Drug: Dobutamine|Drug: Furosemide Montefiore Medical Center Phase 4 2016-05-01 2016-05-06
    NCT00580905 Inflammation Drug: Adenosine|Drug: Sodium Nitroprusside|Drug: Adenosine Vanderbilt University|Vanderbilt University Medical Center Phase 1 2007-06-01 2017-02-17
    NCT00168519 Diabetes Mellitus, Type 2 Drug: nitroprusside, pentalong, imdur, AICAR, isoptin Baker Heart Research Institute|National Health and Medical Research Council, Australia|Hoffmann-La Roche|Diabetes Australia 2002-10-01 2009-12-14
    NCT00535808 Cerebral Oxygenation Drug: nitroprusside|Drug: nitroglycerine|Drug: sevoflurane University Hospital, Ghent Phase 2 2007-10-01 2012-07-12
    NCT02225561 Cardiopulmonary Arrest Procedure: pharmaco- mechanical optimization|Procedure: mechanical optimization only Assistance Publique - Hpitaux de Paris Phase 3 2015-01-01 2016-05-09

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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