Home > Phosphodiesterase (PDE) & > Cilostazol

Cilostazol

西洛他唑,西斯他唑,OPC 13013,OPC13013,OPC 21,OPC-13013,OPC21,OPC-21,

Cilostazol 是存在于心血管系统中的PDE3A抑制剂，IC50为200 nM。

目录号
EY1460
EY1460
EY1460
纯度
99.32%
99.32%
99.32%
规格
25 mg
50 mg
100 mg
原价
280.00
526.00
880
售价
280.00
526.00
880
库存
现货
现货
现货
订购
订购
订购
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  • 生物活性

    Cilostazol is a potent cyclic nucleotide phosphodiesterase type 3 (PDE3) inhibitor with IC50 of 0.2 μM and inhibitor of adenosine uptake.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Cone J, et al. J Cardiovasc Pharmacol, 1999, 34(4), 497-504.

    分子式
    C20H27N5O2    		 分子量
    369.46    		 CAS号
    73963-72-1    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    >20 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    5 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02374957 Peripheral Arterial Disease|Claudication (Finding) Drug: Cilostazol Wake Forest University Health Sciences Phase 4 2015-02-01 2017-03-10
    NCT01915069 Contraception Drug: Cilostazol University of Southern California|Society of Family Planning Phase 2 2013-07-01 2015-05-08
    NCT00446641 Cerebral Infarction Drug: Cilostazol|Drug: placebo Asan Medical Center|Korea Otsuka Pharmaceutical Co., Ltd. Phase 4 2007-03-01 2009-12-10
    NCT00822172 Peripheral Vascular Disease|Intermittent Claudication|Peripheral Arterial Disease Dietary Supplement: Levocarnitine tartrate|Drug: cilostazol Colorado Prevention Center|Otsuka Pharmaceutical Co., Ltd. Phase 4 2008-09-01 2013-04-11
    NCT00684762 Therapeutic Equivalency Drug: Cilostazol 100 mg Tablets|Drug: Cilostazol (Pletal) 100 mg Tablets Mutual Pharmaceutical Company, Inc. Phase 1 2004-03-01 2009-11-18
    NCT00685802 Therapeutic Equivalency, Healthy Drug: Cilostazol 50 mg Tablets|Drug: Cilostazol (Pletal) 50 mg Tablets Mutual Pharmaceutical Company, Inc. Phase 1 2004-06-01 2009-11-18
    NCT01841827 Migraine Drug: Cilostazol|Drug: Placebo Danish Headache Center 2013-04-01 2014-06-05
    NCT01378650 Tinnitus Drug: Cilostazol|Drug: Placebo Jong Woo Chung|Korea Otsuka Pharmaceutical Co., Ltd.|Asan Medical Center 2011-07-01 2014-05-21
    NCT01261234 In-stent Restenosis After Carotid Artery Stenting Drug: Cilostazol or Non-Cilostazol Kobe City General Hospital|Chiba University|Nagoya University|Mie University|Wakayama Medical University|Kyoto University|Osaka University|Kobe University|Foundation for Biomedical Research and Innovation|Okayama University|Yamaguchi University Hospital|Fukuoka University|Nagasaki University Phase 4 2010-12-01 2012-10-14
    NCT00130039 Cerebral Infarction|Atherosclerosis Drug: clopidogrel|Drug: Cilostazol Asan Medical Center|Korea Otsuka International Asia Arab Phase 4 2005-08-01 2010-01-04
    NCT00886574 Type 2 Diabetes Mellitus Drug: Cilostazol|Drug: Aspirin Hanyang University|Ajou University School of Medicine|Kyunghee University Medical Center|Korea University Guro Hospital|Inha University Hospital|Inje University|Hallym University Medical Center Phase 4 2009-04-01 2010-06-03
    NCT01409564 Alzheimer's Dementia Drug: Cilostazol|Drug: Placebo Seoul National University Hospital|Korea OIAA Phase 4 2010-05-01 2014-04-14
    NCT01076478 Polyneuropathy Drug: Cilostazol Otsuka Pharmaceutical, Inc., Philippines Phase 4 2004-03-01 2010-02-25
    NCT02933788 Type 2 Diabetes Mellitus Drug: Cilostazol|Drug: Acetylsalicylic acid Kangbuk Samsung Hospital|Asan Medical Center Phase 4 2016-10-01 2016-10-12
    NCT00938522 Angioplasty, Transluminal, Percutaneous Coronary Drug: Cilostazol|Drug: Placebo Samsung Medical Center Phase 4 2009-07-01 2009-07-20
    NCT01012193 Coronary Artery Disease|Percutaneous Coronary Intervention Drug: cilostazol 100mg bid or clopidogrel 150-mg daily Gyeongsang National University Hospital Phase 4 2008-01-01 2011-05-15
    NCT00573950 Diabetes Mellitus, Type 2|Metabolic Syndrome X Drug: cilostazol|Drug: Placebo Korea University Anam Hospital Phase 4 2007-12-01 2007-12-13
    NCT02486276 Migraine Drug: Cilostazol|Drug: Sumatriptan|Drug: Placebo Danish Headache Center 2015-06-01 2016-01-21
    NCT00272831 Diabetes Mellitus, Type 2|Diabetes Complications Drug: Cilostazol|Drug: Placebo Chinese University of Hong Kong Phase 4 2005-12-01 2009-05-21
    NCT01142284 Peripheral Artery Disease Drug: Cilostazol, Probucol Korea Otsuka Pharmaceutical Co., Ltd. Phase 2 2010-04-01 2010-06-10
    NCT01383395 Healthy Drug: simvastatin/cilostazol Samsung Medical Center|Inje University Phase 1 2011-06-01 2015-05-18
    NCT00741286 Cerebral Infarction Drug: Aspirin|Drug: cilostazol Inje University|Korea Otsuka Pharmaceutical Co., Ltd. Phase 4 2006-11-01 2011-08-04

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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