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Paliperidone

帕潘立酮,帕利哌酮

Paliperidone是多巴胺受体抑拮抗剂。

目录号
EY1459
EY1459
EY1459
纯度
99.72%
99.72%
99.72%
规格
50 mg
100 mg
500 mg
原价
620
990
4110
售价
620
990
4110
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
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  • 生物活性

    Paliperidone, the main active metabolite of Risperidone, is a potent serotonin-2A and dopamine-2 receptor antagonist, used in the treatment of schizophrenia.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Zhu HJ, et al. Neuropsychopharmacology, 2007, 32(4), 757-764.

    分子式
    C23H27FN4O3    		 分子量
    426.48    		 CAS号
    144598-75-4    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    5 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01399450 Schizophrenia Drug: paliperidone Seoul National University Hospital|Johnson & Johnson Phase 4 2011-08-01 2015-12-07
    NCT01860781 Schizophrenia Drug: paliperidone palmitate Seoul National University Hospital Phase 4 2011-08-01 2015-12-06
    NCT02433717 Schizophrenia|Schizoaffective Disorder Drug: Paliperidone ER National Taiwan University Hospital Phase 4 2015-04-01 2015-11-19
    NCT00761189 Schizophrenia Drug: Paliperidone Janssen Korea, Ltd., Korea Phase 4 2008-02-01 2014-01-22
    NCT00761579 Schizophrenia Drug: Paliperidone Janssen Korea, Ltd., Korea Phase 4 2008-04-01 2014-05-01
    NCT02075528 Schizophrenia|Schizoaffective Disorder Drug: Paliperidone ER Taipei City Hospital|Johnson & Johnson Taiwan Ltd|Taipei Institute of Pathology Phase 4 2009-07-01 2014-02-27
    NCT01211704 Bipolar Disorder Drug: Paliperidone Palmitate|Drug: Placebo University of Miami|Ortho-McNeil, Inc. Phase 4 2010-10-01 2014-11-19
    NCT00766064 Posttraumatic Stress Disorder Drug: Paliperidone Yale University Phase 4 2008-09-01 2016-08-22
    NCT00784238 Schizophrenia Drug: Paliperidone Janssen Korea, Ltd., Korea Phase 4 2008-04-01 2014-02-07
    NCT00761605 Schizophrenia Drug: Paliperidone Janssen Korea, Ltd., Korea Phase 4 2008-04-01 2014-09-03
    NCT00488891 Schizophrenia Drug: Paliperidone ER|Drug: Atypical antipsychotics (AAP) Ortho-McNeil Janssen Scientific Affairs, LLC Phase 4 2007-04-01 2012-08-28
    NCT01825928 Methamphetamine Dependence Drug: Paliperidone|Drug: placebo Wei Hao|Central South University Phase 4 2013-02-01 2016-07-27
    NCT00566631 Schizophrenia Drug: Paliperidone Janssen-Cilag International NV Phase 3 2007-07-01 2013-06-27
    NCT01110317 Schizophrenia Drug: paliperidone palmitate 100 mg Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Phase 1 2005-07-01 2010-04-26
    NCT00915512 Schizophrenia Drug: Paliperidone extended-release (ER) Janssen-Cilag Turkey Phase 4 2009-05-01 2013-10-09
    NCT00757705 Schizophrenia Drug: Paliperidone ER Johnson & Johnson Taiwan Ltd Phase 4 2008-03-01 2014-02-05
    NCT01258920 Schizophrenia Drug: Paliperidone palmitate Janssen Pharmaceutical K.K. Phase 3 2010-10-01 2014-06-23
    NCT01662648 Schizophrenia Drug: Paliperidone ER Janssen Pharmaceutica Phase 3 2007-06-01 2014-04-17
    NCT01094249 Schizophrenia|Bipolar Disorder|Psychotic Disorders Drug: divalproex sodium ER/paliperidone ER Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Phase 1 2009-02-01 2014-04-07
    NCT01387542 Schizophrenia Drug: Paliperidone extended release (ER) Janssen-Cilag Ltd.,Thailand Phase 4 2009-08-01 2013-01-29

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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