Nifedipine是血管舒张化合物,是钙离子阻断剂。
Nifedipine is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Ding Y, et al. J Pharmacol Exp Ther,?000, 292(2), 606-609.
分子式 C17H18N2O6 |
分子量 346.33 |
CAS号 21829-25-4 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 50 mg/mL |
Water <1 mg/mL |
Ethanol 10 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01021501 | Hypertension on Chronic Maintenance Hemodialysis | Drug: nifedipine controlled release tablets | Guangzhou First Municipal People Hospital | Phase 4 | 2009-12-01 | 2009-11-27 |
NCT02068404 | Preterm Labor | Drug: Nifedipine | Chantal Csajka|Centre Hospitalier Universitaire Vaudois | Phase 4 | 2014-04-01 | 2015-07-27 |
NCT02902354 | Tocolysis With Nifedipine | Other: Nifedipine for tocolysis | St. Louis University | 2016-09-01 | 2017-03-03 | |
NCT02090920 | Preterm Labor | Drug: Nifedipine | Indiana University | 2011-07-01 | 2017-03-16 | |
NCT00884442 | Bioavailability, Therapeutical Indication Not Studied | Drug: Nifedipine (Gen-nifedipine extended release, previously referred to as Gen-Nifedipine XL)|Drug: Nifedipine (Bayer Healthcare AG manufactured as Adalat XL, Adalat LA, Adalat Crono, Adalat OROS) | SocraTec R&D GmbH|SocraMetrics GmbH | Phase 1 | 2009-04-01 | 2009-10-20 |
NCT02132533 | Preterm Labor | Drug: Nifedipine|Drug: Placebo|Other: Usual care | University of Texas Southwestern Medical Center | Phase 3 | 2014-05-01 | 2016-05-10 |
NCT00972907 | Chronic Anal Fissure | Drug: Nifedipine coated suppositories | RDD Pharma Ltd | Phase 1|Phase 2 | 2009-12-01 | 2011-02-15 |
NCT02023047 | Anal Fissure | Drug: Nifedipine 12 mg coated suppositories | RDD Pharma Ltd | Phase 1|Phase 2 | 2014-03-01 | 2015-11-15 |
NCT02072291 | Embryo Implantation | Drug: Nifedipine | Hadassah Medical Organization | Phase 2 | 2014-03-01 | 2017-02-28 |
NCT00525486 | Preterm Labor | Drug: Nifedipine extended release | The Baruch Padeh Medical Center, Poriya | 2007-12-01 | 2010-12-22 | |
NCT00137501 | Labor, Premature | Drug: Nifedipine | American University of Beirut Medical Center | Phase 3 | 2003-05-01 | 2013-07-18 |
NCT00864617 | Healthy | Drug: Nifedipine Extended Release tablets 60 mg, single dose|Drug: ADALAT CC Extended Release Tablets 60 mg | Actavis Inc. | Phase 1 | 2005-05-01 | 2010-08-13 |
NCT00865891 | Healthy | Drug: Nifedipine Extended Release tablets 60 mg, single dose|Drug: ADALAT CC Extended Release Tablets 60 mg | Actavis Inc. | Phase 1 | 2005-07-01 | 2010-08-13 |
NCT02071589 | Bioequivalence | Drug: Nifedipine soft gelatine capsules|Drug: Nifedipine oral solution | Reig Jofre Group | Phase 1 | 2009-01-01 | 2014-02-22 |
NCT02940548 | Hypertension | Drug: Nifedipine GITS|Drug: Amlodipine besylate | Jing Liu|Bayer|Peking University People's Hospital | Phase 4 | 2016-12-01 | 2016-12-13 |
NCT00185952 | Obstetric Labor, Premature|Venous Thrombosis | Drug: Nifedipine | Stanford University|Santa Clara Valley Health & Hospital System | 2001-11-01 | 2011-06-10 | |
NCT02438371 | Preterm Labor | Drug: Nifedipine|Drug: Indomethacin | The University of Texas Health Science Center, Houston | Phase 4 | 2015-05-01 | 2015-12-03 |
NCT02413515 | Hypertension | Drug: Nifedipine(Adalat_BAY1040) | Bayer | Phase 4 | 2015-03-01 | 2016-09-02 |
NCT01360034 | Obstetric Labor, Premature | Drug: Nifedipine|Drug: Indomethacin | Saint Thomas Hospital, Panama | Phase 3 | 2015-12-01 | 2015-01-01 |
NCT00306462 | Premature Birth|Premature Labor | Drug: Magnesium sulfate|Drug: Oral Nifedipine or placebo | University of Cincinnati|University Hospital | 2006-03-01 | 2009-11-06 | |
NCT01350609 | Hypertension, Essential | Drug: Nifedipine/Candesartan (BAY 98-7106)|Drug: Nifedipine (Adalat, BAY A1040) and Candesartan (Atacand, BAY 12-9333) | Bayer | Phase 1 | 2011-04-01 | 2015-12-08 |
NCT01167153 | Hypertension | Drug: Valsartan/Amlodipine|Drug: Nifedipine | Novartis | Phase 4 | 2010-05-01 | 2012-05-31 |
NCT02641821 | Hypertension | Drug: Nifedipine GITS | Peking University First Hospital|Bayer | Phase 4 | 2015-10-01 | 2015-12-23 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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