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Nifedipine

硝苯地平,Adalat,Procardia,Afeditab,Nifediac

Nifedipine是血管舒张化合物,是钙离子阻断剂。

目录号
EY1453
EY1453
EY1453
EY1453
纯度
99.49%
99.49%
99.49%
99.49%
规格
100 mg
500 mg
1 g
5 g
原价
120
385
492
683
售价
120
385
492
683
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Nifedipine is a dihydropyridine calcium channel blocker, used to lower hypertension and to treat angina.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Ding Y, et al. J Pharmacol Exp Ther,?000, 292(2), 606-609.

    分子式
    C17H18N2O6
    分子量
    346.33
    CAS号
    21829-25-4
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    50 mg/mL
    Water
    <1 mg/mL
    Ethanol
    10 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01021501 Hypertension on Chronic Maintenance Hemodialysis Drug: nifedipine controlled release tablets Guangzhou First Municipal People Hospital Phase 4 2009-12-01 2009-11-27
    NCT02068404 Preterm Labor Drug: Nifedipine Chantal Csajka|Centre Hospitalier Universitaire Vaudois Phase 4 2014-04-01 2015-07-27
    NCT02902354 Tocolysis With Nifedipine Other: Nifedipine for tocolysis St. Louis University 2016-09-01 2017-03-03
    NCT02090920 Preterm Labor Drug: Nifedipine Indiana University 2011-07-01 2017-03-16
    NCT00884442 Bioavailability, Therapeutical Indication Not Studied Drug: Nifedipine (Gen-nifedipine extended release, previously referred to as Gen-Nifedipine XL)|Drug: Nifedipine (Bayer Healthcare AG manufactured as Adalat XL, Adalat LA, Adalat Crono, Adalat OROS) SocraTec R&D GmbH|SocraMetrics GmbH Phase 1 2009-04-01 2009-10-20
    NCT02132533 Preterm Labor Drug: Nifedipine|Drug: Placebo|Other: Usual care University of Texas Southwestern Medical Center Phase 3 2014-05-01 2016-05-10
    NCT00972907 Chronic Anal Fissure Drug: Nifedipine coated suppositories RDD Pharma Ltd Phase 1|Phase 2 2009-12-01 2011-02-15
    NCT02023047 Anal Fissure Drug: Nifedipine 12 mg coated suppositories RDD Pharma Ltd Phase 1|Phase 2 2014-03-01 2015-11-15
    NCT02072291 Embryo Implantation Drug: Nifedipine Hadassah Medical Organization Phase 2 2014-03-01 2017-02-28
    NCT00525486 Preterm Labor Drug: Nifedipine extended release The Baruch Padeh Medical Center, Poriya 2007-12-01 2010-12-22
    NCT00137501 Labor, Premature Drug: Nifedipine American University of Beirut Medical Center Phase 3 2003-05-01 2013-07-18
    NCT00864617 Healthy Drug: Nifedipine Extended Release tablets 60 mg, single dose|Drug: ADALAT CC Extended Release Tablets 60 mg Actavis Inc. Phase 1 2005-05-01 2010-08-13
    NCT00865891 Healthy Drug: Nifedipine Extended Release tablets 60 mg, single dose|Drug: ADALAT CC Extended Release Tablets 60 mg Actavis Inc. Phase 1 2005-07-01 2010-08-13
    NCT02071589 Bioequivalence Drug: Nifedipine soft gelatine capsules|Drug: Nifedipine oral solution Reig Jofre Group Phase 1 2009-01-01 2014-02-22
    NCT02940548 Hypertension Drug: Nifedipine GITS|Drug: Amlodipine besylate Jing Liu|Bayer|Peking University People's Hospital Phase 4 2016-12-01 2016-12-13
    NCT00185952 Obstetric Labor, Premature|Venous Thrombosis Drug: Nifedipine Stanford University|Santa Clara Valley Health & Hospital System 2001-11-01 2011-06-10
    NCT02438371 Preterm Labor Drug: Nifedipine|Drug: Indomethacin The University of Texas Health Science Center, Houston Phase 4 2015-05-01 2015-12-03
    NCT02413515 Hypertension Drug: Nifedipine(Adalat_BAY1040) Bayer Phase 4 2015-03-01 2016-09-02
    NCT01360034 Obstetric Labor, Premature Drug: Nifedipine|Drug: Indomethacin Saint Thomas Hospital, Panama Phase 3 2015-12-01 2015-01-01
    NCT00306462 Premature Birth|Premature Labor Drug: Magnesium sulfate|Drug: Oral Nifedipine or placebo University of Cincinnati|University Hospital 2006-03-01 2009-11-06
    NCT01350609 Hypertension, Essential Drug: Nifedipine/Candesartan (BAY 98-7106)|Drug: Nifedipine (Adalat, BAY A1040) and Candesartan (Atacand, BAY 12-9333) Bayer Phase 1 2011-04-01 2015-12-08
    NCT01167153 Hypertension Drug: Valsartan/Amlodipine|Drug: Nifedipine Novartis Phase 4 2010-05-01 2012-05-31
    NCT02641821 Hypertension Drug: Nifedipine GITS Peking University First Hospital|Bayer Phase 4 2015-10-01 2015-12-23

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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