Home > 5-HT Receptor & 5-HT Receptor & > Ziprasidone HCl

Ziprasidone HCl

盐酸齐拉西酮,盐酸佐帕司通,Ziprasidone,CP-88059,CP 88059,CP88059,

Ziprasidone盐酸盐是5-HT和多巴胺受体拮抗剂，有抗精神病活性。

目录号
EY1449
EY1449
纯度
99.49%
99.49%
规格
50 mg
200 mg
原价
490
860
售价
490
860
库存
现货
现货
订购
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  • 生物活性

    Ziprasidone HCl is a novel and potent dopamine and serotonin (5-HT) receptor antagonist, used in the treatment of schizophrenia and bipolar disorder.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Schmidt AW, et al. Eur J Pharmacol, 2001, 425(3), 197-201.

    分子式
    C21H22Cl2N4OS    		 分子量
    449.4    		 CAS号
    122883-93-6    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    90 mg/mL    		 Water
    <1 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01581866 Healthy Drug: Ziprasidone Hydrochloride Dr. Reddy's Laboratories Limited Phase 1 2004-11-01 2012-04-19
    NCT01581879 Healthy Drug: Ziprasidone Hydrochloride Dr. Reddy's Laboratories Limited Phase 1 2004-11-01 2012-04-19
    NCT01113541 Bipolar Disorder Drug: Ziprasidone HCL (oral) Pfizer Phase 3 2010-07-01 2012-06-05
    NCT00748566 Schizophrenia and Disorders With Psychotic Features Drug: Ziprasidone HCL (oral) Pfizer Phase 4 2008-12-01 2013-04-29
    NCT00555997 Major Depressive Disorder Drug: Ziprasidone|Drug: Ziprasidone|Drug: Placebo Massachusetts General Hospital|Cambridge Health Alliance|University of Connecticut|Vanderbilt University|Psychiatric Medicine Associates, L.L.C.|Cedars-Sinai Medical Center Phase 2 2008-03-01 2014-06-23
    NCT01198353 Schizophrenia|Schizoaffective Disorder Drug: Ziprasidone Soonchunhyang University Hospital|Pfizer Phase 4 2010-09-01 2014-11-18
    NCT02935998 Schizophrenia Drug: Ziprasidone Yang Fude|Pfizer|Beijing HuiLongGuan Hospital Phase 4 2016-10-01 2016-10-14
    NCT00237666 Bipolar II Disorder|Major Depressive Episode Drug: Ziprasidone The Medical Research Network|Liebowitz, Michael R., M.D.|Pfizer Phase 4 2005-02-01 2013-05-09
    NCT00835107 Depression, Bipolar Drug: ziprasidone hydrochloride|Drug: placebo Queen's University|Providence Health & Services|Pfizer|MDS Pharma Services Phase 4 2009-02-01 2015-12-14
    NCT00622739 Bipolar Disorder Drug: Ziprasidone|Drug: Ziprasidone University of Texas Southwestern Medical Center|Stanley Medical Research Institute|Pfizer|Children's Medical Center Dallas Phase 4 2007-02-01 2014-06-25
    NCT01714011 Schizophrenia Drug: Ziprasidone|Drug: Aripiprazole University of Malaya Phase 4 2009-05-01 2012-11-26
    NCT00395031 Schizophrenia|Schizoaffective Disorder Drug: Ziprasidone Manhattan Psychiatric Center|Pfizer Phase 2|Phase 3 2003-09-01 2011-07-28
    NCT00538642 Schizophrenia|Schizoaffective Disorder|Bipolar Disorder Drug: ziprasidone The University of Texas Health Science Center at San Antonio 2007-08-01 2012-11-27
    NCT00579670 Schizophrenia Drug: Ziprasidone Pfizer 2007-10-01 2010-09-16
    NCT01053429 Bipolar Disorder|Schizophrenia Drug: ziprasidone Pfizer 2005-06-01 2010-12-21
    NCT00374543 Generalized Anxiety Disorder|Bipolar Disorder Drug: Ziprasidone|Drug: Placebo Massachusetts General Hospital|Pfizer Phase 4 2006-02-01 2014-03-20
    NCT01293825 Medication Adherence|Bipolar Disorder Drug: ziprasidone University Hospitals Cleveland Medical Center|Pfizer Phase 4 2011-01-01 2014-12-08
    NCT00208559 Autism Drug: Ziprasidone Drexel University College of Medicine|Drexel University Phase 2 2002-02-01 2010-06-15
    NCT00650611 Schizophrenia|Bipolar Disorder|Schizoaffective Disorder Drug: Ziprasidone|Drug: Ziprasidone Pfizer Phase 2 2003-12-01 2008-04-07
    NCT00649064 Schizoaffective Disorder|Schizophrenia Drug: Ziprasidone Pfizer Phase 4 2003-12-01 2008-04-07
    NCT01006551 Schizophrenia Drug: Ziprasidone University of North Carolina, Chapel Hill|Pfizer|National Institute of Mental Health (NIMH) Phase 2 2002-12-01 2009-11-02
    NCT00215150 Social Anxiety Disorder Drug: Ziprasidone|Drug: Sertraline Duke University|Pfizer Phase 2 2004-11-01 2014-10-23
    NCT00472641 Bipolar Disorder Drug: Ziprasidone/Geodon Stanford University|Pfizer Phase 4 2007-01-01 2012-12-11
    NCT01168674 Depression|Bipolar Disorder Drug: ziprasidone|Drug: Sugar pill Tufts Medical Center|Duke University|University of South Carolina Phase 4 2010-02-01 2017-02-21

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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