(R)-(-)-Phenylephrine 盐酸盐是α1-肾上腺受体激动剂。
Phenylephrine HCl is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Clerk A, et al. J Biol Chem,?994, 269(52), 32848-32857.
分子式 C9H14ClNO2 |
分子量 203.67 |
CAS号 61-76-7 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 42 mg/mL |
Water 41 mg/mL |
Ethanol 41 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01354418 | Nasal Congestion | Drug: Phenylephrine HCl Extended Release|Drug: Phenylephrine HCl Immediate Release | Bayer | Phase 1 | 2011-05-01 | 2015-02-20 |
NCT00976209 | Vasomotor Rhinitis|Seasonal Allergic Rhinitis | Drug: Phenylephrine Hydrochloride (HCl) Extended Release (ER) Tablets 30 mg|Drug: Phenylephrine Hydrochloride (HCl) Immediate Release (IR) tablets, 10 mg | Bayer | Phase 3 | 2009-08-01 | 2015-02-20 |
NCT00762567 | Rhinitis | Drug: phenylephrine HCl | Johnson & Johnson Consumer and Personal Products Worldwide | Phase 1 | 2008-09-01 | 2011-10-04 |
NCT00584662 | Chronic Rhinitis | Drug: Oxymetazoline Hydrochloride | University of South Florida | 2005-01-01 | 2012-06-27 | |
NCT02323399 | Hypotension | Drug: Phenylephrine | West-Ward Pharmaceutical | Phase 4 | 2015-02-01 | 2016-05-10 |
NCT01026961 | Heart Rate|Blood Pressure|Arrhythmias | Drug: Phenylephrine HCL|Drug: Phenylephrine HCL/Acetaminophen/Dimethindene Maleate | Novartis | Phase 1|Phase 2 | 2010-09-01 | 2016-03-02 |
NCT02585570 | Disorder of Shoulder|Anesthesia | Drug: Phenylephrine | Inje University | 2015-10-01 | 2016-10-30 | |
NCT01847131 | Nasal Obstruction Present Finding | Drug: oxymetazoline|Drug: Placebo nasal spray | Mahidol University | Phase 4 | 2013-04-01 | 2015-01-03 |
NCT02965924 | Assess Phenylephrine on EVP and IOP | Drug: Phenylephrine 2.5% | Mayo Clinic | 2016-10-01 | 2016-11-15 | |
NCT00874120 | Blood Pressure|Human Experimentation | Drug: Phenylephrine Hydrochloride (HCl) Extended-Release tablets 30 mg|Drug: Placebo | Bayer | Phase 3 | 2008-12-01 | 2015-02-20 |
NCT01378325 | Anesthetic Complication Spinal | Drug: Phenylephrine|Drug: saline | American University of Beirut Medical Center | Phase 4 | 2012-07-01 | 2014-08-11 |
NCT02630121 | Sleep Apnea|Chronic Nasal Congestion | Drug: Oxymetazoline Hydrochloride|Drug: Placebo | University of South Florida | Phase 4 | 2016-11-01 | 2016-09-21 |
NCT02453841 | Adenoidectomy|Functional Endoscopic Sinus Surgery (FESS)|Turbinate Surgery | Drug: Oxymetazoline | Richard Cartabuke|Nationwide Children's Hospital | 2015-12-01 | 2016-12-20 | |
NCT02062996 | Dental Anesthesia|Nasal Surgical Procedures|Intranasal Drug Administration | Drug: Oxymetazoline | Richard Cartabuke|Nationwide Children's Hospital | Phase 2 | 2014-06-01 | 2015-08-06 |
NCT00846326 | Allergic Rhinitis|Tachyphylaxis|Rhinitis Medicamentosa | Drug: oxymetazoline-fluticasone propionate|Drug: Oxymetazoline | Brian J Lipworth|University of Dundee | Phase 4 | 2016-10-24 | |
NCT02203630 | Septic Shock|Sepsis|Shock|Tachycardia|Arrhythmia | Drug: Phenylephrine|Drug: Norepinephrine | Vanderbilt University|National Center for Research Resources (NCRR)|National Center for Advancing Translational Science (NCATS) | Phase 4 | 2014-08-01 | 2014-08-13 |
NCT00781157 | Hypotension | Drug: Phenylephrine bolus | IWK Health Centre | Phase 4 | 2008-01-01 | 2013-05-22 |
NCT00996190 | Cesarean Section|Cardiac Output|Hypotension | Drug: Phenylephrine | Samuel Lunenfeld Research Institute, Mount Sinai Hospital | Phase 4 | 2009-11-01 | 2011-02-22 |
NCT02962986 | Hypotension | Drug: Norepinephrine|Drug: Phenylephrine | Samuel Lunenfeld Research Institute, Mount Sinai Hospital | 2016-11-01 | 2016-11-09 | |
NCT00458003 | Preeclampsia|Hypotension | Drug: Ephedrine|Drug: Phenylephrine | Northwestern University | 2006-07-01 | 2017-01-31 | |
NCT02739399 | Arterial Hypotension|Anaesthesia | Drug: Phenylephrine | Algemeen Ziekenhuis Maria Middelares | Phase 4 | 2016-02-01 | 2016-12-08 |
NCT01413958 | Seasonal Allergic Rhinitis | Drug: Phenylephrine|Drug: Placebo|Drug: Loratadine | Bayer | Phase 3 | 2011-08-01 | 2015-02-20 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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