Phenylephrine HCl

盐酸去氧肾上腺素,NCI-c55641,NCI-c 55641,NCI-c-55641

(R)-(-)-Phenylephrine 盐酸盐是α1-肾上腺受体激动剂。

目录号
EY1447
EY1447
EY1447
纯度
99.36%
99.36%
99.36%
规格
50 mg
100 mg
500 mg
原价
300
450
780
售价
300
450
780
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Phenylephrine HCl is a selective α1-adrenergic receptor agonist, used primarily as a decongestant.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Clerk A, et al. J Biol Chem,?994, 269(52), 32848-32857.

    分子式
    C9H14ClNO2
    分子量
    203.67
    CAS号
    61-76-7
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    42 mg/mL
    Water
    41 mg/mL
    Ethanol
    41 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01354418 Nasal Congestion Drug: Phenylephrine HCl Extended Release|Drug: Phenylephrine HCl Immediate Release Bayer Phase 1 2011-05-01 2015-02-20
    NCT00976209 Vasomotor Rhinitis|Seasonal Allergic Rhinitis Drug: Phenylephrine Hydrochloride (HCl) Extended Release (ER) Tablets 30 mg|Drug: Phenylephrine Hydrochloride (HCl) Immediate Release (IR) tablets, 10 mg Bayer Phase 3 2009-08-01 2015-02-20
    NCT00762567 Rhinitis Drug: phenylephrine HCl Johnson & Johnson Consumer and Personal Products Worldwide Phase 1 2008-09-01 2011-10-04
    NCT00584662 Chronic Rhinitis Drug: Oxymetazoline Hydrochloride University of South Florida 2005-01-01 2012-06-27
    NCT02323399 Hypotension Drug: Phenylephrine West-Ward Pharmaceutical Phase 4 2015-02-01 2016-05-10
    NCT01026961 Heart Rate|Blood Pressure|Arrhythmias Drug: Phenylephrine HCL|Drug: Phenylephrine HCL/Acetaminophen/Dimethindene Maleate Novartis Phase 1|Phase 2 2010-09-01 2016-03-02
    NCT02585570 Disorder of Shoulder|Anesthesia Drug: Phenylephrine Inje University 2015-10-01 2016-10-30
    NCT01847131 Nasal Obstruction Present Finding Drug: oxymetazoline|Drug: Placebo nasal spray Mahidol University Phase 4 2013-04-01 2015-01-03
    NCT02965924 Assess Phenylephrine on EVP and IOP Drug: Phenylephrine 2.5% Mayo Clinic 2016-10-01 2016-11-15
    NCT00874120 Blood Pressure|Human Experimentation Drug: Phenylephrine Hydrochloride (HCl) Extended-Release tablets 30 mg|Drug: Placebo Bayer Phase 3 2008-12-01 2015-02-20
    NCT01378325 Anesthetic Complication Spinal Drug: Phenylephrine|Drug: saline American University of Beirut Medical Center Phase 4 2012-07-01 2014-08-11
    NCT02630121 Sleep Apnea|Chronic Nasal Congestion Drug: Oxymetazoline Hydrochloride|Drug: Placebo University of South Florida Phase 4 2016-11-01 2016-09-21
    NCT02453841 Adenoidectomy|Functional Endoscopic Sinus Surgery (FESS)|Turbinate Surgery Drug: Oxymetazoline Richard Cartabuke|Nationwide Children's Hospital 2015-12-01 2016-12-20
    NCT02062996 Dental Anesthesia|Nasal Surgical Procedures|Intranasal Drug Administration Drug: Oxymetazoline Richard Cartabuke|Nationwide Children's Hospital Phase 2 2014-06-01 2015-08-06
    NCT00846326 Allergic Rhinitis|Tachyphylaxis|Rhinitis Medicamentosa Drug: oxymetazoline-fluticasone propionate|Drug: Oxymetazoline Brian J Lipworth|University of Dundee Phase 4 2016-10-24
    NCT02203630 Septic Shock|Sepsis|Shock|Tachycardia|Arrhythmia Drug: Phenylephrine|Drug: Norepinephrine Vanderbilt University|National Center for Research Resources (NCRR)|National Center for Advancing Translational Science (NCATS) Phase 4 2014-08-01 2014-08-13
    NCT00781157 Hypotension Drug: Phenylephrine bolus IWK Health Centre Phase 4 2008-01-01 2013-05-22
    NCT00996190 Cesarean Section|Cardiac Output|Hypotension Drug: Phenylephrine Samuel Lunenfeld Research Institute, Mount Sinai Hospital Phase 4 2009-11-01 2011-02-22
    NCT02962986 Hypotension Drug: Norepinephrine|Drug: Phenylephrine Samuel Lunenfeld Research Institute, Mount Sinai Hospital 2016-11-01 2016-11-09
    NCT00458003 Preeclampsia|Hypotension Drug: Ephedrine|Drug: Phenylephrine Northwestern University 2006-07-01 2017-01-31
    NCT02739399 Arterial Hypotension|Anaesthesia Drug: Phenylephrine Algemeen Ziekenhuis Maria Middelares Phase 4 2016-02-01 2016-12-08
    NCT01413958 Seasonal Allergic Rhinitis Drug: Phenylephrine|Drug: Placebo|Drug: Loratadine Bayer Phase 3 2011-08-01 2015-02-20

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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