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Sumatriptan Succinate

琥珀酸舒马曲坦,琥珀酸舒马曲普坦,GR-43175,GR43175,GR 43175

Sumatriptan succinate是5-HT1受体激动剂,可作用于偏头疼。

目录号
EY1445
EY1445
纯度
99.13%
99.13%
规格
100 mg
500 mg
原价
880
2700
售价
880
2700
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Sumatriptan Succinate is a triptan sulfa drug containing a sulfonamide group for the treatment of migraine headaches.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Peroutka SJ, et al. Eur J Pharmacol, 1989, 163(1), 133-136.

    分子式
    C18H27N3O6S
    分子量
    413.49
    CAS号
    103628-48-4
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    83 mg/mL
    Water
    83 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01269281 Healthy Drug: Sumatriptan Dr. Reddy's Laboratories Limited Phase 1 2005-07-01 2011-01-03
    NCT01854385 Post-traumatic Headache Drug: Sumatriptan 100 mg University of Washington Phase 2 2013-06-01 2016-05-13
    NCT01507610 Migraine Drug: Sumatriptan Optinose US Inc. Phase 1 2012-01-01 2012-02-28
    NCT01916395 Migraine Drug: sumatriptan and Treximet Gary E. Ruoff, M.D.|GlaxoSmithKline|Westside Family Medical Center, P.C. 2009-12-01 2013-08-02
    NCT00488514 Migraine Disorders Drug: Combination Tablet of Treximet (sumatriptan/naproxen sodium) GlaxoSmithKline Phase 3 2007-07-01 2016-10-11
    NCT00356603 Migraine Disorders|Cluster Headache|Migraine Drug: Sumatriptan Succinate GlaxoSmithKline Phase 3 2006-06-01 2013-05-13
    NCT00875784 Migraine Disorders Drug: TREXIMA Drug: IMITREX(4mg)|Drug: IMITREX(6mg)|Drug: IMITREX Tablet 100mg GlaxoSmithKline Phase 1 2008-05-01 2016-11-03
    NCT01016834 Migraine Device: Sumavel DosePro|Drug: Sumatriptan Zogenix, Inc.|Synteract, Inc. Phase 4 2009-11-01 2011-11-28
    NCT00650247 Healthy Drug: Sumatriptan Succinate Tablets 100 mg|Drug: Imitrex Tablets 100 mg Mylan Pharmaceuticals Phase 1 2004-11-01 2009-11-30
    NCT00648466 Healthy Drug: Sumatriptan Succinate Tablets 100 mg|Drug: Imitrex Tablets 100 mg Mylan Pharmaceuticals Phase 1 2004-11-01 2009-11-30
    NCT00872274 Healthy Drug: sumatriptan 100mg Ranbaxy Laboratories Limited|Ranbaxy Inc. 2008-07-01 2009-03-30
    NCT00383162 Migraine Disorders Drug: Combination Product (sumatriptan succinate / naproxen sodium)|Drug: Placebo GlaxoSmithKline Phase 3 2006-11-01 2016-12-02
    NCT02486276 Migraine Drug: Cilostazol|Drug: Sumatriptan|Drug: Placebo Danish Headache Center 2015-06-01 2016-01-21
    NCT00382993 Migraine Disorders Drug: Placebo|Drug: Combination Product (sumatriptan succinate/naproxen sodium) GlaxoSmithKline Phase 3 2006-12-01 2016-12-02
    NCT00872924 Healthy Drug: sumatriptan 100mg Ranbaxy Laboratories Limited|Ranbaxy Inc. 2008-07-01 2009-03-30
    NCT02485340 Migraine Drug: 5-ISMN (isosorbide-5-mononitrate)|Drug: Sumatriptan|Drug: Placebo Danish Headache Center 2015-04-01 2016-01-21
    NCT00399243 Episodic Cluster Headache|Chronic Cluster Headache Drug: Sumatriptan 4mg Statdose injection Diamond Headache Clinic|GlaxoSmithKline Phase 4 2006-11-01 2009-01-29
    NCT00847405 Healthy Drug: Sumatriptan Succinate|Drug: Imitrex Teva Pharmaceuticals USA Phase 1 2003-03-01 2009-09-01
    NCT00846885 Healthy Drug: Sumatriptan Succinate|Drug: Imitrex Teva Pharmaceuticals USA Phase 1 2004-08-01 2009-09-01
    NCT00723983 Migraine Disorders Drug: Sumatriptan succinate|Drug: NP101 Study Patch NuPathe Inc.|Teva Pharmaceutical Industries Phase 1 2008-11-01 2016-02-02
    NCT00614029 Pharmacokinetics|Bioequivalence Device: Sumatriptan (via Intraject System) Zogenix, Inc. Phase 1 2006-12-01 2009-11-23
    NCT02954276 Migraine Drug: Omexa Sublingual Sumatriptan tablet|Drug: Imitrex Oral Product Targia Pharmaceuticals Ltd.|SoluBest Ltd. Phase 1 2016-03-01 2016-11-02
    NCT01381796 Compare the Bioequivalence Between NP101 Patches Previously Used in the NP101-007 Study and NP101 Patches With Minor Modifications, in Healthy Adult Volunteers. Drug: NP101|Drug: sumatriptan succinate NuPathe Inc.|Teva Pharmaceutical Industries Phase 1 2009-12-01 2016-02-02
    NCT02932488 Healthy Volunteers Drug: Sumatriptan Gitte Moos Knudsen|Rigshospitalet, Denmark Phase 1 2016-09-01 2016-10-12
    NCT00792636 Migraine Disorders Drug: sumatriptan and naproxen sodium combination tablet|Drug: sumatriptan tablet|Drug: naproxen sodium tablet GlaxoSmithKline Phase 4 2008-11-01 2016-10-11

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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