Sumatriptan succinate是5-HT1受体激动剂,可作用于偏头疼。
Sumatriptan Succinate is a triptan sulfa drug containing a sulfonamide group for the treatment of migraine headaches.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Peroutka SJ, et al. Eur J Pharmacol, 1989, 163(1), 133-136.
分子式 C18H27N3O6S |
分子量 413.49 |
CAS号 103628-48-4 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 83 mg/mL |
Water 83 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01269281 | Healthy | Drug: Sumatriptan | Dr. Reddy's Laboratories Limited | Phase 1 | 2005-07-01 | 2011-01-03 |
NCT01854385 | Post-traumatic Headache | Drug: Sumatriptan 100 mg | University of Washington | Phase 2 | 2013-06-01 | 2016-05-13 |
NCT01507610 | Migraine | Drug: Sumatriptan | Optinose US Inc. | Phase 1 | 2012-01-01 | 2012-02-28 |
NCT01916395 | Migraine | Drug: sumatriptan and Treximet | Gary E. Ruoff, M.D.|GlaxoSmithKline|Westside Family Medical Center, P.C. | 2009-12-01 | 2013-08-02 | |
NCT00488514 | Migraine Disorders | Drug: Combination Tablet of Treximet (sumatriptan/naproxen sodium) | GlaxoSmithKline | Phase 3 | 2007-07-01 | 2016-10-11 |
NCT00356603 | Migraine Disorders|Cluster Headache|Migraine | Drug: Sumatriptan Succinate | GlaxoSmithKline | Phase 3 | 2006-06-01 | 2013-05-13 |
NCT00875784 | Migraine Disorders | Drug: TREXIMA Drug: IMITREX(4mg)|Drug: IMITREX(6mg)|Drug: IMITREX Tablet 100mg | GlaxoSmithKline | Phase 1 | 2008-05-01 | 2016-11-03 |
NCT01016834 | Migraine | Device: Sumavel DosePro|Drug: Sumatriptan | Zogenix, Inc.|Synteract, Inc. | Phase 4 | 2009-11-01 | 2011-11-28 |
NCT00650247 | Healthy | Drug: Sumatriptan Succinate Tablets 100 mg|Drug: Imitrex Tablets 100 mg | Mylan Pharmaceuticals | Phase 1 | 2004-11-01 | 2009-11-30 |
NCT00648466 | Healthy | Drug: Sumatriptan Succinate Tablets 100 mg|Drug: Imitrex Tablets 100 mg | Mylan Pharmaceuticals | Phase 1 | 2004-11-01 | 2009-11-30 |
NCT00872274 | Healthy | Drug: sumatriptan 100mg | Ranbaxy Laboratories Limited|Ranbaxy Inc. | 2008-07-01 | 2009-03-30 | |
NCT00383162 | Migraine Disorders | Drug: Combination Product (sumatriptan succinate / naproxen sodium)|Drug: Placebo | GlaxoSmithKline | Phase 3 | 2006-11-01 | 2016-12-02 |
NCT02486276 | Migraine | Drug: Cilostazol|Drug: Sumatriptan|Drug: Placebo | Danish Headache Center | 2015-06-01 | 2016-01-21 | |
NCT00382993 | Migraine Disorders | Drug: Placebo|Drug: Combination Product (sumatriptan succinate/naproxen sodium) | GlaxoSmithKline | Phase 3 | 2006-12-01 | 2016-12-02 |
NCT00872924 | Healthy | Drug: sumatriptan 100mg | Ranbaxy Laboratories Limited|Ranbaxy Inc. | 2008-07-01 | 2009-03-30 | |
NCT02485340 | Migraine | Drug: 5-ISMN (isosorbide-5-mononitrate)|Drug: Sumatriptan|Drug: Placebo | Danish Headache Center | 2015-04-01 | 2016-01-21 | |
NCT00399243 | Episodic Cluster Headache|Chronic Cluster Headache | Drug: Sumatriptan 4mg Statdose injection | Diamond Headache Clinic|GlaxoSmithKline | Phase 4 | 2006-11-01 | 2009-01-29 |
NCT00847405 | Healthy | Drug: Sumatriptan Succinate|Drug: Imitrex | Teva Pharmaceuticals USA | Phase 1 | 2003-03-01 | 2009-09-01 |
NCT00846885 | Healthy | Drug: Sumatriptan Succinate|Drug: Imitrex | Teva Pharmaceuticals USA | Phase 1 | 2004-08-01 | 2009-09-01 |
NCT00723983 | Migraine Disorders | Drug: Sumatriptan succinate|Drug: NP101 Study Patch | NuPathe Inc.|Teva Pharmaceutical Industries | Phase 1 | 2008-11-01 | 2016-02-02 |
NCT00614029 | Pharmacokinetics|Bioequivalence | Device: Sumatriptan (via Intraject System) | Zogenix, Inc. | Phase 1 | 2006-12-01 | 2009-11-23 |
NCT02954276 | Migraine | Drug: Omexa Sublingual Sumatriptan tablet|Drug: Imitrex Oral Product | Targia Pharmaceuticals Ltd.|SoluBest Ltd. | Phase 1 | 2016-03-01 | 2016-11-02 |
NCT01381796 | Compare the Bioequivalence Between NP101 Patches Previously Used in the NP101-007 Study and NP101 Patches With Minor Modifications, in Healthy Adult Volunteers. | Drug: NP101|Drug: sumatriptan succinate | NuPathe Inc.|Teva Pharmaceutical Industries | Phase 1 | 2009-12-01 | 2016-02-02 |
NCT02932488 | Healthy Volunteers | Drug: Sumatriptan | Gitte Moos Knudsen|Rigshospitalet, Denmark | Phase 1 | 2016-09-01 | 2016-10-12 |
NCT00792636 | Migraine Disorders | Drug: sumatriptan and naproxen sodium combination tablet|Drug: sumatriptan tablet|Drug: naproxen sodium tablet | GlaxoSmithKline | Phase 4 | 2008-11-01 | 2016-10-11 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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