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Trifluorothymidine

曲氟尿苷,三氟胸苷,NSC-529182,NSC 529182,NSC 75520,Trifluridine,NSC529182,NSC75520,NSC-75520,FTD,Viroptic,5-Trifluorothymidine

Trifluridine (Viroptic)是一种抗疱疹病毒药,主要用于眼部。是胸苷磷酸化酶(thymidine phosphorylase)抑制剂,还能抑制胸苷酸合成酶(thymidylate synthase)。

目录号
EY1444
EY1444
EY1444
纯度
99.63%
99.63%
99.63%
规格
50 mg
100 mg
200 mg
原价
486
780
1150
售价
486
780
1150
库存
咨询
咨询
现货
订购
订购
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  • 生物活性

    Trifluridine is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Yamashita F, et al. Cancer Chemother Pharmacol,2015 Jun 18.

    分子式
    C10H11F3N2O5
    分子量
    296.21
    CAS号
    70-00-8
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    59 mg/mL
    Water
    59 mg/mL
    Ethanol
    59 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00000635 Herpes Simplex|HIV Infections Drug: Trifluridine|Drug: Bacitracin zinc/Polymyxin B sulfate National Institute of Allergy and Infectious Diseases (NIAID)|Glaxo Wellcome
    2012-03-29
    NCT01867866 Advanced Solid Tumors Drug: TAS-102|Drug: Trifluridine Taiho Oncology, Inc. Phase 1 2013-06-01 2015-12-21
    NCT03031691 Metastatic Colorectal Cancer Drug: brontictuzumab|Drug: trifluridine/tipiracil OncoMed Pharmaceuticals, Inc. Phase 1 2017-01-01 2017-03-09
    NCT00002037 Mycobacterium Avium-Intracellulare Infection|HIV Infections Drug: Trifluridine Amgen|NIH AIDS Clinical Trials Information Service
    2005-06-23
    NCT02848443 Metastatic Colorectal Cancer Drug: Trifluridine/tipiracil hydrochloride (S 95005)|Drug: Oxaliplatin|Drug: Bevacizumab Institut de Recherches Internationales Servier|Servier Phase 1 2016-05-01 2016-11-23
    NCT02602327 Colon Cancer|Rectal Cancer|Liver Metastases Drug: Tas-102|Device: SIR-Sphere University of California, San Francisco Phase 1 2016-10-01 2016-12-02
    NCT02743221 Metastatic Colorectal Cancer Drug: Trifluridine/tipiracil hydrochloride (S 95005)|Drug: Capecitabine|Drug: Bevacizumab|Drug: Bevacizumab Institut de Recherches Internationales Servier|Servier Phase 2 2016-04-01 2017-03-16
    NCT00000138 Keratitis, Herpetic|Ocular Herpes Simplex Drug: Prednisolone Phosphate|Drug: Acyclovir National Eye Institute (NEI) Phase 3 1989-05-01 2009-09-16
    NCT00081835 Vaccinia Drug: NP-016 Vaccine Immune Globulin (IV-VIG) National Eye Institute (NEI)|National Institutes of Health Clinical Center (CC) Phase 2 2004-04-19 2017-01-24
    NCT02921737 Pancreatic Cancer Drug: TAS-102 University of Florida|Taiho Oncology, Inc. Phase 2 2017-06-01 2017-03-06
    NCT02920476 Squamous Cell Lung Carcinoma Drug: TAS-102 University of Florida|Taiho Oncology, Inc. Phase 2 2017-04-01 2017-03-03
    NCT02500043 Refractory Metastatic Gastric Cancer Drug: TAS-102|Drug: Placebo Taiho Oncology, Inc. Phase 3 2015-12-01 2017-01-19
    NCT02301117 Advanced Solid Tumors Drug: TAS-102 Taiho Oncology, Inc. Phase 1 2015-01-01 2016-08-29
    NCT02301104 Advanced Solid Tumors Drug: TAS-102 Taiho Oncology, Inc. Phase 1 2015-01-01 2016-10-13
    NCT02261532 Advanced or Metastatic Solid Tumors Drug: TAS-102 Taiho Pharmaceutical Co., Ltd. Phase 1 2014-09-01 2017-02-05
    NCT01955837 Colorectal Cancer Drug: TAS-102|Drug: Placebo Taiho Pharmaceutical Co., Ltd. Phase 3 2013-09-01 2017-02-05
    NCT01867879 Advanced Solid Tumors (Excluding Breast Cancer) Drug: TAS-102|Drug: Placebo Taiho Oncology, Inc. Phase 1 2013-06-01 2015-11-06
    NCT01607957 Colorectal Cancer Drug: TAS-102|Drug: Placebo Taiho Oncology, Inc. Phase 3 2012-06-01 2015-12-21
    NCT02848079 Colorectal Neoplasms Drug: combined TAS-102 and TAS-OX Yale University Phase 1|Phase 2 2016-08-01 2017-01-24
    NCT02654639 Metastatic Colorectal Cancer Drug: TAS-102 and Bevacizumab Georgetown University Phase 2 2016-02-01 2016-08-17

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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