Trifluridine (Viroptic)是一种抗疱疹病毒药,主要用于眼部。是胸苷磷酸化酶(thymidine phosphorylase)抑制剂,还能抑制胸苷酸合成酶(thymidylate synthase)。
Trifluridine is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Yamashita F, et al. Cancer Chemother Pharmacol,2015 Jun 18.
分子式 C10H11F3N2O5 |
分子量 296.21 |
CAS号 70-00-8 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 59 mg/mL |
Water 59 mg/mL |
Ethanol 59 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00000635 | Herpes Simplex|HIV Infections | Drug: Trifluridine|Drug: Bacitracin zinc/Polymyxin B sulfate | National Institute of Allergy and Infectious Diseases (NIAID)|Glaxo Wellcome | | 2012-03-29 | |
NCT01867866 | Advanced Solid Tumors | Drug: TAS-102|Drug: Trifluridine | Taiho Oncology, Inc. | Phase 1 | 2013-06-01 | 2015-12-21 |
NCT03031691 | Metastatic Colorectal Cancer | Drug: brontictuzumab|Drug: trifluridine/tipiracil | OncoMed Pharmaceuticals, Inc. | Phase 1 | 2017-01-01 | 2017-03-09 |
NCT00002037 | Mycobacterium Avium-Intracellulare Infection|HIV Infections | Drug: Trifluridine | Amgen|NIH AIDS Clinical Trials Information Service | | 2005-06-23 | |
NCT02848443 | Metastatic Colorectal Cancer | Drug: Trifluridine/tipiracil hydrochloride (S 95005)|Drug: Oxaliplatin|Drug: Bevacizumab | Institut de Recherches Internationales Servier|Servier | Phase 1 | 2016-05-01 | 2016-11-23 |
NCT02602327 | Colon Cancer|Rectal Cancer|Liver Metastases | Drug: Tas-102|Device: SIR-Sphere | University of California, San Francisco | Phase 1 | 2016-10-01 | 2016-12-02 |
NCT02743221 | Metastatic Colorectal Cancer | Drug: Trifluridine/tipiracil hydrochloride (S 95005)|Drug: Capecitabine|Drug: Bevacizumab|Drug: Bevacizumab | Institut de Recherches Internationales Servier|Servier | Phase 2 | 2016-04-01 | 2017-03-16 |
NCT00000138 | Keratitis, Herpetic|Ocular Herpes Simplex | Drug: Prednisolone Phosphate|Drug: Acyclovir | National Eye Institute (NEI) | Phase 3 | 1989-05-01 | 2009-09-16 |
NCT00081835 | Vaccinia | Drug: NP-016 Vaccine Immune Globulin (IV-VIG) | National Eye Institute (NEI)|National Institutes of Health Clinical Center (CC) | Phase 2 | 2004-04-19 | 2017-01-24 |
NCT02921737 | Pancreatic Cancer | Drug: TAS-102 | University of Florida|Taiho Oncology, Inc. | Phase 2 | 2017-06-01 | 2017-03-06 |
NCT02920476 | Squamous Cell Lung Carcinoma | Drug: TAS-102 | University of Florida|Taiho Oncology, Inc. | Phase 2 | 2017-04-01 | 2017-03-03 |
NCT02500043 | Refractory Metastatic Gastric Cancer | Drug: TAS-102|Drug: Placebo | Taiho Oncology, Inc. | Phase 3 | 2015-12-01 | 2017-01-19 |
NCT02301117 | Advanced Solid Tumors | Drug: TAS-102 | Taiho Oncology, Inc. | Phase 1 | 2015-01-01 | 2016-08-29 |
NCT02301104 | Advanced Solid Tumors | Drug: TAS-102 | Taiho Oncology, Inc. | Phase 1 | 2015-01-01 | 2016-10-13 |
NCT02261532 | Advanced or Metastatic Solid Tumors | Drug: TAS-102 | Taiho Pharmaceutical Co., Ltd. | Phase 1 | 2014-09-01 | 2017-02-05 |
NCT01955837 | Colorectal Cancer | Drug: TAS-102|Drug: Placebo | Taiho Pharmaceutical Co., Ltd. | Phase 3 | 2013-09-01 | 2017-02-05 |
NCT01867879 | Advanced Solid Tumors (Excluding Breast Cancer) | Drug: TAS-102|Drug: Placebo | Taiho Oncology, Inc. | Phase 1 | 2013-06-01 | 2015-11-06 |
NCT01607957 | Colorectal Cancer | Drug: TAS-102|Drug: Placebo | Taiho Oncology, Inc. | Phase 3 | 2012-06-01 | 2015-12-21 |
NCT02848079 | Colorectal Neoplasms | Drug: combined TAS-102 and TAS-OX | Yale University | Phase 1|Phase 2 | 2016-08-01 | 2017-01-24 |
NCT02654639 | Metastatic Colorectal Cancer | Drug: TAS-102 and Bevacizumab | Georgetown University | Phase 2 | 2016-02-01 | 2016-08-17 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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