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Dabigatran

达比加群,BIBR 953,BIBR 953ZW,BIB-953,BIBR-953,BIB 953,BIB953,

Dabigatran是可逆的高活性直接凝血酶抑制剂(DTI),Ki为4.5 nM。

目录号
EY1442
EY1442
EY1442
EY1442
纯度
99.69%
99.69%
99.69%
99.69%
规格
2 mg
5 mg
10 mg
50 mg
原价
730
970
1700
5260
售价
730
970
1700
5260
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Dabigatran (BIBR 953) is a potent nonpeptide thrombin inhibitor with an IC50 of 9.3 nM in a cell-free assay.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

    静脉注射给药

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Hauel NH, et al. J Med Chem. 2002, 45(9), 1757-1766.

    分子式
    C25H25N7O3
    分子量
    471.51
    CAS号
    211914-51-1
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    <1 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01590823 Blood Coagulation Disorders Drug: Dabigatran Etexilate 110 mg Nova Scotia Health Authority|Capital Health, Canada|Dalhousie University|Universit de Montral Phase 1 2012-07-01 2012-10-31
    NCT02426229 Scleroderma|Interstitial Lung Disease Drug: dabigatran etexilate Medical University of South Carolina|National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Phase 1 2016-02-01 2017-03-22
    NCT01976507 Atrial Fibrillation|Atrial Flutter Drug: dabigatran etexilate mesylate Vanderbilt University Medical Center|Boehringer Ingelheim Phase 4 2013-10-01 2017-02-21
    NCT02173717 Healthy Drug: Dabigatran etexilate|Drug: Rifampicin Boehringer Ingelheim Phase 1 2009-06-01 2014-06-24
    NCT01385683 Healthy Drug: Dabigatran then dabigatran and clarithromycin|Drug: Clarithromycin and dabigatran then dabigatran Centre Hospitalier Universitaire de Saint Etienne|Groupe de Recherche sur la Thrombose Phase 1 2011-06-01 2012-03-21
    NCT01546883 Atrial Fibrillation Drug: Dabigatran etexilate (Pradaxa) University of Utah Phase 4 2012-02-01 2015-09-10
    NCT01769703 Transient Ischemic Attack|Minor Ischemic Stroke Drug: Dabigatran 110/150 mg BID University of Alberta Phase 2 2012-02-01 2014-10-29
    NCT01852162 Coronary Artery Disease Drug: Dabigatran|Drug: Placebo University of Florida 2012-02-01 2015-03-10
    NCT02389582 Coronary Disease Drug: Dabigatran|Drug: Enoxaparin University of Sao Paulo General Hospital|Fundao de Amparo Pesquisa do Estado de So Paulo Phase 4 2014-05-01 2016-04-28
    NCT02256683 (Atrial Fibrillation) or (Atrial Flutter)|Thrombosis of Left Atrial Appendage Drug: Dabigatran etexilate|Drug: Phenprocoumon Johannes Gutenberg University Mainz|Boehringer Ingelheim|German Atrial Fibrillation Network Phase 4 2014-07-01 2016-02-26
    NCT01290757 Healthy Drug: Dabigatran etexilate|Drug: Dabigatran etexilate Boehringer Ingelheim Phase 1 2011-01-01 2014-05-08
    NCT02596555 Pulmonary Embolism Drug: Dabigatran Prof. Stavros Konstantinides, MD|European Georges Pompidou Hospital|Johannes Gutenberg University Mainz Phase 4 2016-01-01 2016-04-26
    NCT01711853 Renal Insufficiency, Chronic Drug: Dabigatran Etexilate Boehringer Ingelheim Phase 1 2012-10-01 2015-01-09
    NCT02223260 Venous Thromboembolism Drug: dabigatran Boehringer Ingelheim Phase 2 2014-09-01 2016-07-28
    NCT02331602 Atrial Fibrillation Drug: Rivaroxaban|Drug: Dabigatran Yokohama City University Medical Center|Yokohama City University Phase 4 2013-07-01 2015-08-04
    NCT02102633 Healthy Drug: Dabigatran|Drug: Bosutinib|Drug: Dabigatran Pfizer Phase 1 2014-05-01 2014-06-23
    NCT00808067 Atrial Fibrillation Drug: dabigatran dose 1|Drug: dabigatran dose 2 Boehringer Ingelheim Phase 3 2008-11-01 2014-06-03
    NCT01868243 Primary Disease Drug: Dabigatran|Drug: Warfarin Hospital Ana Nery Phase 2|Phase 3 2013-08-01 2015-09-14
    NCT02044367 Healthy Drug: Dabigatran etexilate|Drug: Dabigatran etexilate|Drug: Dabigatran etexilate Boehringer Ingelheim Phase 1 2014-01-01 2015-05-01
    NCT00844415 Venous Thromboembolism Drug: dabigatran etexilate Boehringer Ingelheim Phase 2 2009-06-01 2014-06-03
    NCT02170675 Healthy Drug: Dabigatran etexilate|Drug: Ketoconazole Boehringer Ingelheim Phase 1 2009-06-01 2014-06-20
    NCT01083732 Venous Thromboembolism Drug: dabigatran etexilate Boehringer Ingelheim Phase 2 2010-03-01 2016-11-02
    NCT01468155 Atrial Fibrillation Drug: dabigatran Allan Skanes|Boehringer Ingelheim|Lawson Health Research Institute Phase 4 2011-11-01 2012-10-16

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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