Estrone

雌酚酮

Estrone (雌酮) 为雌激素。

目录号
EY1440
EY1440
EY1440
纯度
99.53%
99.53%
99.53%
规格
500 mg
1 g
5 g
原价
369
490
790
售价
369
490
790
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Estrone is an estrogenic hormone.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Guo, J.Y., et al. 2004. J. Nutr. 134: 179-182. PMID: 14704314
    [2] Imai, Y., et al. 2002. Jpn. J. Cancer Res. 93: 231-235. PMID: 11927002

    分子式
    C18H22O2
    分子量
    270.37
    CAS号
    53-16-7
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    54 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00449202 Obesity Drug: oleoyl-estrone (MP 101) Manhattan Pharmaceuticals Phase 2 2006-06-01 2007-03-16
    NCT00449254 Obesity Drug: oleoyl-estrone (MP-101) Manhattan Pharmaceuticals Phase 2 2006-10-01 2007-06-04
    NCT01260805 Bioequivalence|Ethinylestradiol|Gestodene|Harmonet Drug: Reference Drug|Drug: Test Drug Pfizer Phase 1 2010-09-01 2011-02-18
    NCT01089049 Breast Cancer Dietary Supplement: FemMED Breast Health Formula Nutrasource Diagnostics Inc. Phase 1|Phase 2 2009-08-01 2012-03-23
    NCT00623116 Kallmann Syndrome Drug: Short withdrawal of testosterone, gonadotropins or estrogenic compounds (see below) Hospital for Children and Adolescents, Finland 2007-12-01 2008-02-13
    NCT00711607 Healthy Drug: nomegestrol acetate and estradiol Merck Sharp & Dohme Corp.|CRS Mannheim GmbH Phase 1 2007-05-01 2015-08-18
    NCT00864214 Menopause Drug: bioidentical hormone (Biest)|Drug: bioidentical hormone (Biest)|Drug: bioidentical hormone (Biest)|Drug: bioidentical hormone (Vivelle-Dot) Mayo Clinic Phase 1 2008-06-01 2012-01-12
    NCT00917735 Breast Cancer Drug: Green tea extract supplement|Other: Placebo University of Minnesota - Clinical and Translational Science Institute|National Cancer Institute (NCI) Phase 2 2009-07-01 2016-01-25
    NCT02463383 Breast Cancer Drug: Alcohol + ibuprofen|Drug: Alcohol + placebo Professor Lars Ove Dragsted|Technical University of Denmark|University of Copenhagen Early Phase 1 2013-09-01 2015-06-03
    NCT00668174 Breast Cancer Prevention Behavioral: Exercise Fred Hutchinson Cancer Research Center Phase 2|Phase 3 1997-01-01 2012-11-26
    NCT00866437 Premenstrual Syndrome Drug: Skin test panel|Drug: Skin test panel EVE Medical Systems Ltd. Phase 2 2009-04-01 2010-06-15
    NCT00873262 Premenstrual Syndrome Drug: Skin test panel and desensitization kit|Drug: Skin test panel and solvent EVE Medical Systems Ltd. Phase 2 2009-04-01 2010-06-15
    NCT00522262 Breast Neoplasms Behavioral: Aerobic exercise intervention AHS Cancer Control Alberta|Canadian Breast Cancer Research Alliance|University of Alberta|University of Calgary 2002-06-01 2015-01-14
    NCT02100553 Healthy Drug: CE/BZA|Drug: Itraconazole|Drug: CE/BZA|Drug: CE/BZA|Drug: Itraconazole|Drug: CE/BZA Pfizer Phase 1 2014-04-01 2015-03-23
    NCT01817400 Infertility, Female|Obesity Other: Microdialysis|Dietary Supplement: Vascepa - Fish Oil|Drug: Aspirin|Drug: Pioglitazone University of Colorado, Denver|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Early Phase 1 2013-03-01 2015-03-12
    NCT00470119 Breast Cancer|Obesity|Weight Changes Behavioral: behavioral dietary intervention|Behavioral: Exercise intervention Fred Hutchinson Cancer Research Center|National Cancer Institute (NCI) 2004-12-01 2012-09-07
    NCT00491595 Drug Toxicity Drug: High Dose Soy isoflavones University of North Carolina|National Cancer Institute (NCI)|University of North Carolina, Chapel Hill Phase 1 2004-03-01 2007-06-25
    NCT00309855 Aging Drug: Placebo|Drug: Testosterone|Drug: Anastrazole|Drug: Dutasteride Mayo Clinic|GlaxoSmithKline Phase 1 2005-12-01 2012-07-27
    NCT01411644 Premature Ovarian Failure (POF)|Incipient Ovarian Failure|Poor Response After Ovarian Hyperstimulation|Early Menopause|Hypergonadotropic Amenorrhea UMC Utrecht|Erasmus Medical Center|Medical Center Alkmaar|University Medical Center Groningen|Leiden University Medical Center|Medisch Spectrum Twente|Isala|Department of Clinical Pharmacy, University Medical Centre St Radboud, The Netherlands.|Amphia Hospital|Deventer Ziekenhuis|Catharina Ziekenhuis Eindhoven|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)|Academisch Ziekenhuis Maastricht|VU University Medical Center 2005-01-01 2015-12-02
    NCT02892942 Infertility Drug: Gonal-F|Drug: Cetrotide|Drug: Cetrotide Assistance Publique - Hpitaux de Paris|MerckSerono Pharmaceuticals Phase 4 2016-09-01 2016-09-01

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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