Cabazitaxel

卡巴他塞,RPR-116258A,XRP-6258,TXD 258,taxoid XRP6258,XRP 6258,XRP-6258,TXD-258

Cabazitaxel(XRP6258; RPR-116258A)是天然的taxoid 10-deacetylbaccatin III半合成衍生物,具有抗肿瘤活性。

目录号
EY1437
EY1437
EY1437
EY1437
纯度
99.63%
99.63%
99.63%
99.63%
规格
5 mg
10 mg
50 mg
100 mg
原价
296
495
780
1400
售价
296
495
780
1400
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Cabazitaxel is a semi-synthetic derivative of a natural taxoid.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] EMEA/H/C/002018, 2011.

    分子式
    C45H57NO14
    分子量
    835.93
    CAS号
    183133-96-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    100 mg/mL
    Water
    <1 mg/mL
    Ethanol
    50 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01518283 Hormone Refractory Prostate Cancer Drug: Cabazitaxel 10 mg/m2 Spanish Oncology Genito-Urinary Group Phase 2 2012-05-01 2016-10-13
    NCT02512458 Bone Metastatic Prostate Cancer Drug: Cabazitaxel Hellenic Cooperative Oncology Group|Sanofi Phase 2 2015-07-01 2016-11-25
    NCT01830231 Urothelium Transitional Cell Carcinoma Drug: Cabazitaxel|Drug: Vinflunine Associaci per a la Recerca Oncologica, Spain Phase 2|Phase 3 2012-10-01 2014-01-27
    NCT01335204 Prostate Cancer|Prostatic Neoplasms Drug: Cabazitaxel plus bavituximab Medical University of South Carolina|Peregrine Pharmaceuticals Phase 1|Phase 2 2011-06-01 2013-03-20
    NCT03043989 Prostate Cancer Drug: Docetaxel|Drug: Cabazitaxel|Drug: Clarithromycin Sidney Kimmel Comprehensive Cancer Center Phase 1 2017-02-15 2017-02-13
    NCT01650285 Prostate Cancer Drug: Cabazitaxel Brown University Phase 2 2013-01-01 2015-06-09
    NCT01254279 Prostate Cancer Metastatic Drug: CABAZITAXEL Sanofi Phase 3 2010-12-01 2015-01-19
    NCT02478502 Testicular Cancer Drug: cabazitaxel Jan Oldenburg|Sanofi|University Hospital, Akershus Phase 2 2015-06-01 2017-01-16
    NCT01740570 Brain Cancer Drug: Cabazitaxel M.D. Anderson Cancer Center|Sanofi Phase 1|Phase 2 2013-04-01 2013-03-07
    NCT01981668 Prostatic Neoplasms Drug: cabazitaxel Nova Scotia Cancer Centre|Sanofi Phase 1 2014-03-18
    NCT02560337 Ovarian Cancer Drug: Cabazitaxel|Drug: Tocotrienol Vejle Hospital Phase 2 2015-09-01 2016-10-13
    NCT01845792 Prostate Cancer Drug: Cabazitaxel with Abiraterone Acetate|Drug: Cabazitaxel University of Colorado, Denver|Janssen Services, LLC Phase 2 2013-07-01 2017-03-06
    NCT02204332 Colorectal Cancer Drug: Cabazitaxel|Other: Best Supportive Care Hospital Clinico Universitario de Santiago|Fundaci贸n Ramn Domnguez Phase 2 2013-03-01 2014-07-29
    NCT01693549 Breast Cancer Drug: Cabazitaxel Hellenic Cooperative Oncology Group|Sanofi Phase 2 2012-09-01 2017-02-13
    NCT01941550 High-Risk Cancer Drug: Cabazitaxel chemotherapy RWTH Aachen University Phase 2 2013-07-01 2016-09-12
    NCT01913652 Dedifferentiated Liposarcoma Drug: Cabazitaxel|Drug: Prolonged infusional ifosfamide European Organisation for Research and Treatment of Cancer - EORTC|Sanofi Phase 2 2014-10-01 2016-10-11
    NCT01750866 Castrate-resistant Metastatic Prostate Cancer Drug: Cabazitaxel|Drug: Prednisone|Drug: Granulocyte colony-stimulating factor (G-CSF) Case Comprehensive Cancer Center Phase 2 2013-02-01 2013-10-15
    NCT01420250 Prostate Cancer Drug: Cabazitaxel|Radiation: Intensity Modulated Radiation Therapy (IMRT)|Drug: Anti-Androgen Therapy: Bicalutamide|Genetic: Luteinizing Hormone-Releasing Hormone (LHRH) Agonist Sidney Kimmel Cancer Center at Thomas Jefferson University|Sanofi|Thomas Jefferson University Phase 1 2011-09-01 2016-10-19
    NCT01757171 Gastric Adenocarcinoma|Gastroesophageal Adenocarcinoma|Distal Esophageal Adenocarcinoma Drug: Cabazitaxel Weill Medical College of Cornell University|Sanofi Phase 2 2012-12-01 2017-02-28
    NCT01620242 Recurrent Head and Neck Cancer|Metastatic Head and Neck Cancer Drug: Cabazitaxel UNICANCER Phase 2 2012-04-01 2016-06-16

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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