Posaconazole是广谱的第二代三唑类化合物,具有抗真菌活性。
Posaconazole is a sterol C14ɑ demethylase inhibitor with an IC50 of 0.25 nM.
0 nM -4 nM
20 mg/kg/d口服
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Benaim G, et al. J Med Chem. 2006, 49(3), 892-389.
分子式 C37H42F2N8O4 |
分子量 700.78 |
CAS号 171228-49-2 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 100 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02492802 | Mycoses | Drug: posaconazole | University Medical Center Groningen | 2015-08-01 | 2016-11-17 | |
NCT00811642 | Fungal Infection | Drug: Posaconazole | Merck Sharp & Dohme Corp. | Phase 3 | 2008-11-01 | 2015-06-04 |
NCT02358499 | Fungal Infections | Drug: Posaconazole | Children's Mercy Hospital Kansas City | Phase 1 | 2015-01-01 | 2016-01-26 |
NCT00799071 | Chronic Granulomatous Disease | Drug: posaconazole (PSZ) | Radboud University | Phase 2 | 2009-02-01 | 2012-05-30 |
NCT02968134 | Systemic Fungal Infections | Drug: Posaconazole | Royal Brisbane and Women's Hospital|The University of Queensland | Phase 4 | 2016-11-01 | 2016-11-16 |
NCT02020213 | Clinical Infection | Drug: Posaconazole | Taichung Veterans General Hospital|Merck Sharp & Dohme Corp. | Phase 4 | 2013-12-01 | 2014-12-11 |
NCT02372357 | Hematological Malignancy | Drug: Posaconazole prophylaxis 120 mg/m tid|Procedure: Blood sampling | Universitaire Ziekenhuizen Leuven|Institutul Clinic Fundeni Bucharest | Phase 4 | 2012-02-01 | 2015-03-02 |
NCT00936117 | Leukemia|Fungal Infection | Drug: Posaconazole | M.D. Anderson Cancer Center|Schering-Plough | Phase 2 | 2009-09-01 | 2015-08-24 |
NCT00550732 | Mycoses | Drug: Posaconazole | Merck Sharp & Dohme Corp.|JSS Medical Research Inc. | Phase 2 | 2007-12-01 | 2015-08-04 |
NCT00817765 | HIV Infection|Fungal Infection | Drug: Posaconazole|Drug: Fosamprenavir|Drug: Ritonavir | Radboud University|GlaxoSmithKline | Phase 1 | 2009-01-01 | 2009-11-27 |
NCT02805946 | Allogeneic Stem Cell Transplant|Acute Graft Versus Host Disease|Acute Myeloid Leucaemia|Myelo Dysplastic Syndrome | Drug: posaconazole | Radboud University|Universitaire Ziekenhuizen Leuven | Phase 4 | 2016-08-01 | 2016-06-15 |
NCT01200355 | Acute Myelogenous Leukemia|Myelodysplastic Syndrome | Drug: micafungin|Drug: posaconazole | Memorial Sloan Kettering Cancer Center|Astellas Pharma US, Inc. | Phase 4 | 2010-09-01 | 2016-04-25 |
NCT01667107 | Fungal Infection | Drug: Posaconazole|Drug: Calogen庐 | Merck Sharp & Dohme Corp. | Phase 4 | 2013-01-01 | 2014-12-22 |
NCT00726609 | Mycoses | Drug: Posaconazole | Merck Sharp & Dohme Corp. | 2006-01-01 | 2015-02-16 | |
NCT01419678 | Lung Transplant Infection|Fungal Infection | Other: collection of blood samples for PK testing | University of Pittsburgh|Merck Sharp & Dohme Corp. | 2011-10-01 | 2014-12-05 | |
NCT01777763 | Fungal Infections | Drug: Posaconazole 200 mg|Drug: Posaconazole 300 mg | Merck Sharp & Dohme Corp. | Phase 1 | 2009-06-01 | 2016-01-25 |
NCT00177749 | Fungal Infection | Drug: Posaconazole | University of Pittsburgh|Schering-Plough | Phase 4 | 2004-08-01 | 2008-12-16 |
NCT02387983 | Fungal Infection | Drug: Posaconazole | Merck Sharp & Dohme Corp. | Phase 1 | 2015-05-01 | 2016-05-26 |
NCT00750737 | Invasive Fungal Infections|Hematologic Malignancies | Drug: Posaconazole|Drug: ABLC | M.D. Anderson Cancer Center|Enzon Pharmaceuticals, Inc. | Phase 3 | 2008-06-01 | 2016-08-22 |
NCT00686543 | Fungal Infection|Acute Myelogenous Leukemia|Neutropenia | Drug: Posaconazole | Merck Sharp & Dohme Corp. | Phase 4 | 2007-12-01 | 2015-10-08 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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