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Posaconazole

泊沙康唑,伯沙康唑,SCH56592,SCH 56592,SCH-56592

Posaconazole是广谱的第二代三唑类化合物,具有抗真菌活性。

目录号
EY1435
EY1435
EY1435
EY1435
EY1435
纯度
99.59%
99.59%
99.59%
99.59%
99.59%
规格
1 mg
5 mg
10 mg
50 mg
100 mg
原价
330
770
1120
4650
8300
售价
330
770
1120
4650
8300
库存
现货
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Posaconazole is a sterol C14ɑ demethylase inhibitor with an IC50 of 0.25 nM.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

    0 nM -4 nM

  • 动物实验

    20 mg/kg/d口服

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Benaim G, et al. J Med Chem. 2006, 49(3), 892-389.

    分子式
    C37H42F2N8O4
    分子量
    700.78
    CAS号
    171228-49-2
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    100 mg/mL
    Water
    <1 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02492802 Mycoses Drug: posaconazole University Medical Center Groningen 2015-08-01 2016-11-17
    NCT00811642 Fungal Infection Drug: Posaconazole Merck Sharp & Dohme Corp. Phase 3 2008-11-01 2015-06-04
    NCT02358499 Fungal Infections Drug: Posaconazole Children's Mercy Hospital Kansas City Phase 1 2015-01-01 2016-01-26
    NCT00799071 Chronic Granulomatous Disease Drug: posaconazole (PSZ) Radboud University Phase 2 2009-02-01 2012-05-30
    NCT02968134 Systemic Fungal Infections Drug: Posaconazole Royal Brisbane and Women's Hospital|The University of Queensland Phase 4 2016-11-01 2016-11-16
    NCT02020213 Clinical Infection Drug: Posaconazole Taichung Veterans General Hospital|Merck Sharp & Dohme Corp. Phase 4 2013-12-01 2014-12-11
    NCT02372357 Hematological Malignancy Drug: Posaconazole prophylaxis 120 mg/m tid|Procedure: Blood sampling Universitaire Ziekenhuizen Leuven|Institutul Clinic Fundeni Bucharest Phase 4 2012-02-01 2015-03-02
    NCT00936117 Leukemia|Fungal Infection Drug: Posaconazole M.D. Anderson Cancer Center|Schering-Plough Phase 2 2009-09-01 2015-08-24
    NCT00550732 Mycoses Drug: Posaconazole Merck Sharp & Dohme Corp.|JSS Medical Research Inc. Phase 2 2007-12-01 2015-08-04
    NCT00817765 HIV Infection|Fungal Infection Drug: Posaconazole|Drug: Fosamprenavir|Drug: Ritonavir Radboud University|GlaxoSmithKline Phase 1 2009-01-01 2009-11-27
    NCT02805946 Allogeneic Stem Cell Transplant|Acute Graft Versus Host Disease|Acute Myeloid Leucaemia|Myelo Dysplastic Syndrome Drug: posaconazole Radboud University|Universitaire Ziekenhuizen Leuven Phase 4 2016-08-01 2016-06-15
    NCT01200355 Acute Myelogenous Leukemia|Myelodysplastic Syndrome Drug: micafungin|Drug: posaconazole Memorial Sloan Kettering Cancer Center|Astellas Pharma US, Inc. Phase 4 2010-09-01 2016-04-25
    NCT01667107 Fungal Infection Drug: Posaconazole|Drug: Calogen庐 Merck Sharp & Dohme Corp. Phase 4 2013-01-01 2014-12-22
    NCT00726609 Mycoses Drug: Posaconazole Merck Sharp & Dohme Corp. 2006-01-01 2015-02-16
    NCT01419678 Lung Transplant Infection|Fungal Infection Other: collection of blood samples for PK testing University of Pittsburgh|Merck Sharp & Dohme Corp. 2011-10-01 2014-12-05
    NCT01777763 Fungal Infections Drug: Posaconazole 200 mg|Drug: Posaconazole 300 mg Merck Sharp & Dohme Corp. Phase 1 2009-06-01 2016-01-25
    NCT00177749 Fungal Infection Drug: Posaconazole University of Pittsburgh|Schering-Plough Phase 4 2004-08-01 2008-12-16
    NCT02387983 Fungal Infection Drug: Posaconazole Merck Sharp & Dohme Corp. Phase 1 2015-05-01 2016-05-26
    NCT00750737 Invasive Fungal Infections|Hematologic Malignancies Drug: Posaconazole|Drug: ABLC M.D. Anderson Cancer Center|Enzon Pharmaceuticals, Inc. Phase 3 2008-06-01 2016-08-22
    NCT00686543 Fungal Infection|Acute Myelogenous Leukemia|Neutropenia Drug: Posaconazole Merck Sharp & Dohme Corp. Phase 4 2007-12-01 2015-10-08

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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