Home > Phosphodiesterase (PDE) & > Aminophylline

Aminophylline

氨茶碱,乙二胺茶碱,Phyllocontin,Somopphyllin,Aminocadol

Aminophylline是一种竞争性的，非选择性的磷酸二酯酶抑制剂，IC50为0.12 mM，也是非选择性的腺苷受体拮抗剂。

目录号
EY1433
EY1433
EY1433
纯度
99.25%
99.25%
99.25%
规格
100 mg
500 mg
5 g
原价
120
198
310
售价
120
198
310
库存
现货
现货
现货
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  • 生物活性

    Aminophylline is a competitive nonselective phosphodiesterase inhibitor with an IC50 of 0.12 mM and also a nonselective adenosine receptor antagonist.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Chanda, et al., Antiepileptic drugs and methylxanthines: clinical significance. Pol. J. Pharmacol. 50, 80-82, (1998).
    [2] Thakker, et al. Analytical Profiles of Drug Substances 2nd ed.,, (1982) 2, 1-44.
    [3] Crisanti, et al., Aminophylline alters the core temperature response to acute hypoxemia in newborn and older guinea pigs. Am. J. Physiol. 277, R829-R835, (1999).

    分子式
    2C7H8N4O2.C2H8N2    		 分子量
    420.43    		 CAS号
    317-34-0     		储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    50 mg/mL     		Water
    80 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01240824 Bladder Cancer Drug: aminophylline University of Virginia Early Phase 1 2010-07-01 2014-04-10
    NCT02522013 Post-dural Puncture Headache Drug: Aminophylline|Drug: isotonic saline The First Affiliated Hospital of Zhengzhou University Phase 3 2015-10-01 2016-10-27
    NCT01336140 Patients With Severe Chronic Kidney Disease Being Evaluated With Nuclear Stress Testing of the Heart Using the Stress Agent Regadenoson (Lexiscan). Drug: Aminophylline|Drug: Placebo Rush University Medical Center|John H. Stroger Hospital Phase 4 2011-06-01 2013-01-04
    NCT01530464 High Altitude Pulmonary Hypertension Drug: Aminophylline|Drug: Ambrisentan|Drug: Aminophylline plus ambrisentan Thies Schroeder|Duke University Phase 1 2012-02-01 2013-11-28
    NCT01250496 Patients Being Assessed With Nuclear Stress Testing of the Heart Using the Stress Agent Regadenoson (Lexiscan). Drug: Aminophylline|Drug: Placebo Rush University Medical Center Phase 4 2010-11-01 2012-11-27
    NCT01794078 Acute Mountain Sickness and Fatigue Drug: Aminophylline 400 mg|Drug: Ambrisentan 5 mg|Other: Placebo Robert J Noveck, M.D.|United States Department of Defense|Duke University Phase 1 2013-09-01 2015-11-11
    NCT01594489 Acute Kidney Injury Drug: Aminophylline|Drug: Hydration plus N-acetylcisteine Ospedale Misericordia e Dolce Phase 4 2009-01-01 2012-10-26
    NCT01759862 Function of Renal Transplant Drug: Aminophylline|Other: Theophylline drug levels|Drug: Placebo Stanford University 2012-11-01 2014-06-30
    NCT01245595 Acute Kidney Injury Drug: Aminophylline|Drug: Placebo Stanford University 2010-11-01 2015-06-03
    NCT02983422 Acute Kidney Injury Drug: aminophylline|Drug: frusemide|Drug: normal saline Shanghai Jiao Tong University Affiliated Sixth People Hospital Early Phase 1 2016-12-01 2016-12-02
    NCT01655524 Coronary Artery Disease Drug: ASSUAGE Protocol Rush University Medical Center Phase 4 2012-07-01 2014-03-14
    NCT01587027 Mountain Sickness Drug: Aminophylline|Drug: Methazolamide|Drug: Aminophylline and Methazolamide Poudre Valley Health System|Defense Advanced Research Projects Agency|University of Colorado, Denver Phase 1 2011-12-01 2016-12-22
    NCT02270827 Asthma Drug: Aminophylline|Drug: Hydrocortisone Royal Brompton & Harefield NHS Foundation Trust Phase 4 2014-06-01 2015-10-26
    NCT00312273 Cardiac Arrest Drug: Aminophylline (250mg IV +/- a second dose of 250mg IV) Vancouver General Hospital|Heart and Stroke Foundation of Canada|Vancouver Coastal Health Research Institute Phase 2 2001-01-01 2006-07-26
    NCT02150304 Postdural Puncture Headache Diskapi Yildirim Beyazit Education and Research Hospital 2014-01-01 2015-08-04
    NCT01022151 Anaesthesia Drug: Placebo [group P]|Drug: 0.2 mL/kg of aminophylline 10 mg/mL [group A2]|Drug: 0.2 mL/kg of aminophylline 15 mg/mL [group A3]|Drug: 0.2 mL/kg of aminophylline 20 mg/mL [group A4]|Drug: 0.2 mL/kg of aminophylline 25 mg/mL [group A5]|Drug: Doxapram 1 mg/kg [group D] King Faisal University Phase 2 2007-11-01 2010-11-18
    NCT02276170 Acute Kidney Injury Stanford University|Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 2014-10-01 2016-05-16
    NCT00442338 Asthma Drug: montelukast sodium|Drug: montelukast sodium|Drug: aminophylline hydrate Merck Sharp & Dohme Corp. Phase 3 2007-03-01 2016-09-07
    NCT01280071 Venoarteriolar Reflex Drug: aminophylline Tel-Aviv Sourasky Medical Center 2011-01-19
    NCT01702025 Physiological Function in Low Oxygen Environment Drug: Placebo|Drug: Aminophylline|Drug: Methazolamide|Drug: Aminophylline+Methazolamide Colorado State University|Defense Advanced Research Projects Agency|University of Colorado, Denver Phase 1|Phase 2 2012-06-01 2014-10-23
    NCT01708655 Cystic Fibrosis Other: Sweat Evaporimeter measurement University of Colorado, Denver|Cystic Fibrosis Foundation Therapeutics 2011-12-01 2014-12-01
    NCT00596427 Diabetes Drug: Colesevelam HCL|Drug: Placebo Carine Beysen|KineMed 2007-11-01 2012-10-10
    NCT00722033 Regional Blood Flow|Premature Birth|Electroencephalography Drug: 3 protocols of Indomethacin administration Pontificia Universidad Catolica de Chile Phase 2 2008-08-01 2008-08-13
    NCT02611414 Dyspepsia Device: anodal tDCS|Device: Sham tDCS Hospital Ernesto Dornelles Phase 2|Phase 3 2016-01-01 2016-05-17

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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