Home > 5-HT Receptor & 5-HT Receptor & > Mosapride Citrate

Mosapride Citrate

柠檬酸莫沙必利,AS-4370,AS 4370,AS4370

Mosapride citrate是促胃肠动力化合物，是5HT4激动剂。

目录号
EY1431
EY1431
EY1431
纯度
99.64%
99.64%
99.64%
规格
5 mg
10 mg
50 mg
原价
220
340
1130
售价
220
340
1130
库存
现货
现货
现货
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  • 生物活性

    Mosapride Citrate is a gastroprokinetic agent that acts as a selective 5HT4 agonist.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Masahiro Tajika,et al. Efficacy of mosapride citrate with polyethylene glycol solution for colonoscopy preparation. World J Gastroenterol. 2012 May 28; 18(20): 2517–2525. Published online 2012 May 28. doi: 10.3748/wjg.v18.i20.2517.
    [2] In Su Jung,et al. Endoscopic Evaluation of Gastric Emptying and Effect of Mosapride Citrate on Gastric Emptying. Yonsei Med J. 2010 Jan 1; 51(1): 33–38. Published online 2009 Dec 29. doi: 10.3349/ymj.2010.51.1.33
    [3] Qing Liu,et al. Efficacy of mosapride plus proton pump inhibitors for treatment of gastroesophageal reflux disease: A systematic review. World J Gastroenterol. 2013 Dec 21; 19(47): 9111–9118. Published online 2013 Dec 21. doi: 10.3748/wjg.v19.i47.9111.

    分子式
    C27H37ClFN3O12    		 分子量
    650.05    		 CAS号
    112885-42-4    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    100 mM    		 Water
    <1 mg/mL    		 Ethanol
    10 mM

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02201316 Gastritis Drug: Reference mosapride citrate (GASMOTIN)|Drug: GR107719B (Formulation 1)|Drug: GR107719B (Formulation 2) GlaxoSmithKline Phase 1 2014-02-01 2014-07-31
    NCT02264587 Diabetic Gastroparesis Drug: Mosapride|Drug: domperidone Liangzhou Wei|Sumitomo Pharmaceutical (Suzhou) Co., Ltd.|Qingdao University Phase 4 2014-10-01 2014-10-14
    NCT02056405 Postoperative Ileus Drug: Mosapride|Drug: Placebo Hospital Italiano de Buenos Aires Phase 4 2015-12-01 2015-12-16
    NCT01284764 Foreign Body Left During Endoscopic Examination Drug: Mosapride Inje University Phase 3 2011-01-01 2011-10-04
    NCT02106130 Healthy Drug: Rebamipide|Drug: Mosapride citrate IlDong Pharmaceutical Co Ltd Phase 1 2013-05-01 2014-04-03
    NCT00742872 Constipation-Predominant Irritable Bowel Syndrome Drug: Mosapride Citrate|Drug: Placebo American University of Beirut Medical Center Phase 3 2008-09-01 2013-02-27
    NCT02180334 Diabetes Mellitus, Type 2 Drug: Mosapride citrate|Drug: Linagliptin|Drug: Acetaminophen (paracetamol) Seoul National University Hospital|Daewoong Pharmaceutical Co. LTD. Phase 4 2014-07-01 2014-06-30
    NCT02433847 Constipated Irritable Bowel Syndrome|Chronic Constipation|Healthy Drug: Mosapride Seoul National University Hospital Phase 4 2015-05-01 2015-04-29
    NCT00729339 Gastroesophageal Reflux Disease Drug: mosapride for the first month and placebo for the 2nd month|Drug: placebo for the first and mosapride for the second month Lotung Poh-Ai Hospital|Tomorrow Medical Foundation Phase 4 2008-06-01 2009-05-12
    NCT01094847 Bioequivalence Drug: DWJ1252 Daewoong Pharmaceutical Co. LTD. Phase 1 2010-04-01 2011-05-19
    NCT00663897 Functional Dyspepsia|Epigastric Pain Syndrome|Post Prandial Distress Syndrome Drug: lansoprazole|Drug: mosapride Lotung Poh-Ai Hospital|Tomorrow Medical Foundation Phase 4 2008-05-01 2009-10-08
    NCT02606617 Type 2 Diabetes Drug: Mosapride|Drug: Placebo Third Military Medical University Phase 4 2015-12-01 2015-11-15
    NCT02984930 Gastroesophageal Reflux Disease Drug: Administration of study drug (esomeprazole, mosapride)|Drug: Administration of study drug (esomeprazole, placebo tablet)|Procedure: upper endoscopy, scintigraphy Gangnam Severance Hospital 2016-12-01 2016-12-06
    NCT01505777 Irritable Bowel Syndrome Without Diarrhea Drug: Probiotics (Medirac)|Drug: Probiotics (Medirac)|Drug: Probiotics (Medirac)|Drug: Probiotics (Medirac)|Drug: Probiotics (Medirac) placebo/mosapride placebo Hanmi Pharmaceutical Company Limited Phase 2 2011-05-01 2013-04-04
    NCT03040817 Gastric Peroral Endoscopic Pyloromyotomy (G-POEM) Procedure: Gastric peroral endoscopic pyloromyotomy (G-POEM)|Drug: Esomeprazole + Mosapride Zhongda Hospital 2017-02-16 2017-01-31
    NCT01411501 Constipation Other: acupuncture|Drug: mosapride citrate Guang'anmen Hospital of China Academy of Chinese Medical Sciences|Ministry of Science and Technology of the Peoples Republic of China Phase 3 2011-09-01 2015-11-08
    NCT01781897 Functional Constipation Device: acupuncture|Drug: mosapride Huazhong University of Science and Technology Phase 1 2013-02-01 2015-03-17
    NCT01274793 Functional Constipation|Functional Diarrhea Drug: Mosapride Citrate tablet|Device: Low-dose acupuncture|Device: High-dose acupuncture Huazhong University of Science and Technology|The Fifth Hospital of Wuhan|Wuhan Union Hospital, China|Guangzhou University of Traditional Chinese Medicine Phase 1 2010-11-01 2015-03-17
    NCT02831543 Functional Dyspepsia Drug: Motireb 5/100 mg|Drug: Mosapride citrate|Drug: Placebo IlDong Pharmaceutical Co Ltd Phase 3 2016-04-01 2016-07-11
    NCT02887573 Colorectal Polyps Drug: Free-residue nutrients|Drug: Low fiber diet|Procedure: Colon capsule endoscopy|Drug: 2L PEG|Drug: 4L PEG|Drug: PEG|Drug: Mosapride citrate Kaichun Wu|Xijing Hospital of Digestive Diseases Phase 4 2014-01-01 2017-02-04
    NCT02982668 Severe Stroke|Acute Stroke|Dysphagia Other: Initial enteral feeding|Drug: erythromycin Xijing Hospital|Tang-Du Hospital|Xi'an Central Hospital|Shaanxi Provincial People's Hospital|Hanzhong Central Hospital|Yan'an University Affiliated Hospital 2017-01-01 2016-12-13
    NCT01984931 Nausea|Vomiting Drug: Trimebutine Maleate (NEWBUTIN SR 300 mg Tab)|Drug: Metoclopramide hydrochloride monohydrate CM Chungmu Hospital|Korea United Pharm. Inc. Phase 3 2013-10-01 2013-11-08

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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