(S)-Timolol Maleate是非选择性β-肾上腺素受体拮抗剂,对β1和β2受体亚型的Ki分别为1.97和2.0 nM。
Timolol Maleate is a non-selective, beta-adrenergic receptor antagonist for β1/β2 with Ki of 1.97 nM/2.0 nM.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Hall RA, et al. Arch Int Pharmacodyn Ther, 1975, 213(2), 251-263.
分子式 C17H28N4O7S |
分子量 432.49 |
CAS号 26921-17-5 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 85 mg/mL |
Water <1 mg/mL |
Ethanol 85 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01607671 | Optic Neuropathy, Ischemic|Anterior Ischemic Optic Neuropathy|Ischemic Optic Neuropathy|Optic Neuropathy, Anterior Ischemic | Drug: Timolol maleate | Fraser Health | Phase 1 | 2012-06-01 | 2015-05-22 |
NCT01685398 | Hemangioma | Drug: 0.5% timolol maleate eye drop|Drug: Normal saline | Mahidol University | Phase 3 | 2012-09-01 | 2012-11-26 |
NCT02145884 | Hemangioma | Drug: timolol maleate 0.5% gel | Rady Children's Hospital, San Diego|Valeant Pharmaceuticals | Phase 2 | 2014-05-01 | 2017-02-09 |
NCT02422017 | Venous Leg Ulcers | Drug: Timolol|Other: Local care treatment | Centre Hospitalier Universitaire, Amiens | Phase 2 | 2015-04-01 | 2016-11-29 |
NCT01533376 | Sturge Weber Syndrome|Port-wine Mark | Drug: Timolol|Drug: Preservative free artificial tear gel. | Wills Eye|University of Medicine and Dentistry of New Jersey | Phase 1 | 2012-02-01 | 2015-12-18 |
NCT02484716 | Hemorrhagic Hereditary Telangiectasia (HHT) | Drug: Timolol nasal spray|Drug: Placebo nasal spray | Hospices Civils de Lyon | Phase 2 | 2015-06-01 | 2016-11-08 |
NCT02731287 | Hemangioma | Drug: Timolol|Drug: Placebo | Fundaci贸 Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | Phase 2 | 2014-03-01 | 2016-04-06 |
NCT00735449 | Glaucoma|Ocular Hypertension | Drug: Fixed combination of brimonidine tartrate 0.2% timolol maleate 0.5%|Drug: timolol maleate 0.5%|Drug: latanoprost 0.005% | Allergan | Phase 4 | 2008-07-01 | 2012-11-13 |
NCT02774590 | Acne Vulgaris|Rosacea | Drug: Timolol | Johns Hopkins University | Phase 1 | 2016-03-01 | 2016-05-12 |
NCT00823043 | Open-angle Glaucoma|Ocular Hypertension | Drug: timolol hemihydrate|Drug: timolol maleate | Vistakon Pharmaceuticals | 2009-01-01 | 2015-02-18 | |
NCT01749904 | Open-Angle Glaucoma|Ocular Hypertension | Drug: BOL-303259-X|Drug: Timolol|Drug: BOL-303259-X | Bausch & Lomb Incorporated | Phase 3 | 2013-01-01 | 2015-11-10 |
NCT01749930 | Open-Angle Glaucoma|Ocular Hypertension | Drug: BOL-303259-X|Drug: Timolol|Drug: BOL-303259-X | Bausch & Lomb Incorporated | Phase 3 | 2013-01-01 | 2015-11-10 |
NCT01707381 | Ocular Hypertension|Open Angle Glaucoma | Drug: BOL-303259-X|Drug: Timolol maleate | Bausch & Lomb Incorporated | Phase 2 | 2012-11-01 | 2014-11-24 |
NCT01250457 | Benign Vascular Periocular Lesions | Drug: topical Timolol | Loyola University | Phase 4 | 2010-06-01 | 2012-10-29 |
NCT01147601 | Hemangioma|Infant | Drug: topical 0.5% Timolol|Drug: Control (placebo) group | Oregon Health and Science University | Early Phase 1 | 2010-03-01 | 2010-06-18 |
NCT00757835 | Glaucoma | Drug: treatment with latanoprost/timolol fixed combination|Drug: latanoprost/timolol fixed combination drops | Aristotle University Of Thessaloniki|Alcon Research | Phase 4 | 2008-05-01 | 2014-05-09 |
NCT00972257 | Glaucoma | Drug: treatment with dorzolamide/timolol|Drug: treatment with brimonidine/timolol | Aristotle University Of Thessaloniki | Phase 4 | 2009-01-01 | 2014-05-09 |
NCT02214680 | Healthy | Drug: Combigan (Combination of Brimonidine and Timolol)|Drug: Timolol | Carmel Medical Center | Phase 2 | 2015-10-01 | 2015-10-13 |
NCT01408056 | Infantile Hemangiomas | Drug: Timolol 0.5% Gel Forming Solution (GFS)|Drug: Mupirocin 2% Ointment | Children's Hospital of Philadelphia|Society for Pediatric Dermatology | Phase 2 | 2011-02-01 | 2014-01-16 |
NCT00832377 | Glaucoma | Drug: timolol/dorzolamide combination | Merck Sharp & Dohme Corp. | Phase 2 | 2009-04-01 | 2015-02-06 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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