Brimonidine Tartrate

酒石酸溴莫尼定

Brimonidine Tartrate 是一种高度选择性 α-adrenergic receptor 拮抗剂,其对α2A adrenoreceptor的 EC50 为 0.45 nM ,并用于治疗开角型青光眼或高眼压症。

目录号
EY1425
EY1425
纯度
99.24%
99.24%
规格
100 mg
500 mg
原价
330
960
售价
330
960
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Brimonidine Tartrate is a highly selective α-adrenergic receptor agonist with EC50 of 0.45 nM for the α2A adrenoreceptor, and used to treat open-angle glaucoma or ocular hypertension.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] WoldeMussie E, et al. Invest Ophthalmol Vis Sci, 2001, 42(12), 2849-2855.

    分子式
    C15H16BrN5O6
    分子量
    442.22
    CAS号
    70359-46-5
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    90 mg/mL
    Water
    75 mg/mL
    Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01229410 Vitrectomy Drug: 400 g Brimonidine Tartrate Implant|Drug: 200 g Brimonidine Tartrate Implant Allergan Phase 1 2010-12-01 2013-07-02
    NCT02003534 Glaucoma, Open-Angle|Ocular Hypertension Drug: 0.15% Brimonidine Tartrate Allergan Phase 4 2010-07-01 2014-06-24
    NCT02039765 Hyperemia Drug: Brimonidine tartrate Bausch & Lomb Incorporated|ORA, Inc. Phase 1 2014-02-01 2014-03-28
    NCT02856919 Chronic Persistent Vascular Facial Erythema Drug: brimonidine tartrate Galderma Brasil Ltda.|Eurotrials Brasil Consultores Cientificos Ltda Phase 4 2016-06-01 2016-08-02
    NCT02568111 Relapsing-Remitting Multiple Sclerosis (RRMS) Drug: peginterferon beta-1a|Drug: brimonidine tartrate|Drug: Vehicle Gel Biogen Phase 4 2016-02-01 2016-04-21
    NCT00800423 Corneal Edema|Visual Acuity Drug: Brimonidine Tartrate 0.2%|Drug: Timolol maleate 0.5% Rabin Medical Center Phase 3 2009-01-01 2008-12-01
    NCT00658619 Macular Degeneration Drug: 400 g Brimonidine Tartrate Implant|Drug: 200 g Brimonidine Tartrate Implant|Other: Sham (no implant) Allergan Phase 2 2008-05-01 2013-03-13
    NCT01959230 Hyperemia Drug: Brimonidine Tartrate|Drug: Vehicle Bausch & Lomb Incorporated|ORA, Inc. Phase 3 2013-11-01 2014-07-24
    NCT02761174 Telangiectasias Drug: Brimonidine|Other: IPL+air-cooling Merete Haedersdal|Skinperium, Christine Dierickx|Ellipse A/S Agern All 11, 2970 Hrsholm|Bispebjerg Hospital Phase 4 2016-03-01 2016-05-02
    NCT00697541 Erythematous Rosacea Drug: 0.18% COL-118 facial gel (1.8 mg brimonidine)|Drug: 0.2% brimonidine ophthalmic solution (0.1 mg brimonidine tartrate/drop)|Drug: Advanced Eye Relief|Drug: COL-118 facial gel vehicle Galderma Phase 2 2008-05-01 2014-08-06
    NCT01959243 Hyperemia Drug: Brimonidine Tartrate|Drug: Vehicle Bausch & Lomb Incorporated|ORA, Inc. Phase 3 2014-02-01 2014-07-24
    NCT00972374 Rhegmatogenous Macula-off Retinal Detachment Drug: 400 ug Brimonidine Implant|Drug: 200 ug Brimonidine Implant|Other: Sham (no implant) Allergan Phase 2 2009-11-01 2013-03-13
    NCT02249065 Rosacea Drug: Brimonidine Galderma Laboratories, L.P. Phase 4 2014-09-01 2016-01-20
    NCT02818816 Prostate Cancer Drug: brimonidine tartrate 0.2%|Other: Carboxymethylcellulose Eye Drops University Health Network, Toronto Phase 4 2016-07-01 2016-07-27
    NCT01675609 Ocular Redness Drug: Placebo|Drug: Brimonidine tartrate 0.025% Eye Therapies, LLC Phase 2 2012-08-01 2014-07-28
    NCT01687426 Glaucoma and Ocular Hypertension Drug: Brimonidine Tartrate 0.025%|Drug: Vehicle Eye Therapies, LLC Phase 1 2012-09-01 2012-12-21
    NCT01250236 Impact of Brimonidine on the Cornea Drug: brimonidine 0.1%|Drug: placebo Augenarztpraxis Breisach 2010-12-01 2010-12-02
    NCT00457795 Open-angle Glaucoma|Ocular Hypertension Drug: brimonidine 0.1% (Alphagan P) Allergan Phase 4 2006-12-01 2011-10-18
    NCT02975557 Dry Eye|Ocular Graft vs Host Disease|Meibomian Gland Dysfunction Drug: Brimonidine 0.15%|Drug: Brimonidine 0.075%|Drug: Placebo University of Illinois at Chicago Phase 1|Phase 2 2016-05-01 2016-11-23
    NCT02659670 Rosacea Other: internet survey|Drug: brimonidine topical gel 0.33% Wake Forest University Health Sciences Phase 4 2016-01-01 2016-11-01

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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