Home > Calcium Channel & > Ranolazine 2HCl

Ranolazine 2HCl

盐酸雷诺嗪,RS-43285,RS43285,RS 43285

Ranolazine dihydrochloride具有抗心律失常活性。

目录号
EY1423
EY1423
EY1423
纯度
99.63%
99.63%
99.63%
规格
100 mg
200 mg
500 mg
原价
590
940
1500
售价
590
940
1500
库存
现货
现货
现货
订购
订购
订购
订购
订购
订购
具体折扣请咨询客服

  • 生物活性

    Ranolazine 2HCl is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Belardinelli L, et al. Heart,?006, 92 Suppl 4, iv6-iv14.

    分子式
    C24H35Cl2N3O4    		 分子量
    500.46    		 CAS号
    95635-56-6    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    100 mg/mL    		 Water
    100 mg/mL    		 Ethanol
    <1 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02360397 Ventricular Premature Complexes|Myocardial Ischemia Drug: ranolazine Kent Hospital, Rhode Island|Gilead Sciences Phase 2 2014-12-01 2016-09-01
    NCT02239926 Diarrhea Predominant Irritable Bowel Syndrome Drug: Ranolazine|Drug: Placebo Mayo Clinic Phase 2|Phase 3 2014-09-01 2016-02-16
    NCT01705509 Cardiomyopathy Drug: Ranolazine Cardiovascular Institute of the South Clinical Research Corporation|Gilead Sciences 2012-09-01 2016-01-26
    NCT01996618 Premature Ventricular Beats Drug: Ranolazine Walter Reed National Military Medical Center Phase 4 2014-01-01 2015-04-30
    NCT01435174 End-stage Renal Disease|Cardiovascular Disease Drug: Ranolazine|Procedure: Pharmacokinetic Blood and Dialysate Sampling|Procedure: QT Interval University of Michigan|Gilead Sciences Phase 4 2011-10-01 2014-06-24
    NCT02251457 Myotonia Congenita (Enrollment Complete)|Paramyotonia Congenita|Myotonic Dystrophy 1 Drug: Ranolazine Ohio State University|Gilead Sciences Phase 2 2014-08-01 2017-03-18
    NCT02133352 Pulmonary Hypertension|Diastolic Left Ventricular Dysfunction Drug: Ranolazine Harrison Farber|Gilead Sciences|Boston University Phase 4 2011-07-01 2014-05-06
    NCT01304095 Coronary Artery Disease|Angina|Metabolic Syndrome Drug: Ranolazine Atlanta Heart Specialists, LLC|Gilead Sciences Phase 4 2011-01-01 2013-07-09
    NCT01546597 Type 2 Diabetes Mellitus Drug: Metformin|Drug: Ranolazine Gilead Sciences Phase 1 2012-02-01 2012-07-09
    NCT02252406 Stable Angina|Metabolic Syndrome Drug: Ranolazine|Drug: Placebo University of Florida Phase 4 2015-09-01 2017-02-02
    NCT01546558 Type 2 Diabetes Mellitus Drug: Metformin|Drug: Ranolazine Gilead Sciences Phase 1 2012-02-01 2012-07-09
    NCT02156336 Diabetic Peripheral Neuropathic Pain Drug: Ranolazine|Drug: Placebo Horizons International Peripheral Group|Gilead Sciences Phase 4 2014-05-01 2017-02-09
    NCT01174173 Angina|Pulmonary Arterial Hypertension Drug: Ranolazine Northwestern University|Gilead Sciences Phase 3 2010-06-01 2015-04-22
    NCT01767987 Acute Coronary Syndrome Drug: Ranolazine|Drug: Placebo Harvey Hahn|Gilead Sciences|Kettering Health Network Phase 2 2012-11-01 2015-10-20
    NCT02147067 Microvascular Angina Drug: Ranolazine|Drug: Placebo Emory University|Gilead Sciences Phase 4 2014-09-01 2016-07-27
    NCT01558830 Chronic Stable Angina|Coronary Artery Disease|Atrial Fibrillation|Ventricular Tachycardia Drug: ranolazine|Drug: placebo Cardiovascular Consultants of Nevada|Gilead Sciences Phase 4 2012-01-01 2012-03-20
    NCT01721967 Hypertrophic Cardiomyopathy Drug: Ranolazine Duke University|Gilead Sciences Phase 4 2012-11-01 2017-01-19
    NCT03044964 Angina Drug: Ranolazine|Drug: Placebo Amit Malhotra, MD|Gilead Sciences|Stern Cardiovascular Foundation, Inc. Phase 4 2017-01-10 2017-02-03
    NCT01345188 Cardiomyopathy|Chest Pain|Dyspnea Drug: Ranexa|Drug: Placebo Midwest Cardiovascular Research Foundation|Gilead Sciences Phase 4 2011-04-01 2014-09-24
    NCT01163721 Diabetes Mellitus, Type 2 Drug: Ranolazine|Drug: Placebo Gilead Sciences Phase 2 2010-06-01 2013-07-19
    NCT01491061 Coronary Artery Disease Drug: Ranolazine|Drug: Placebo University of Roma La Sapienza Phase 4 2014-01-01 2013-03-06
    NCT01797484 Coronary Artery Disease|Acute Myocardial Ischemia Drug: Ranolazine Universittsklinikum Hamburg-Eppendorf Phase 2|Phase 3 2013-07-01 2015-06-10
    NCT01221272 Myocardial Perfusion Imaging|Myocardial Ischemia Drug: Ranolazine|Drug: Placebo to match ranolazine|Procedure: SPECT MPI|Behavioral: Exercise Gilead Sciences Phase 4 2010-09-01 2014-08-21
    NCT02687269 Myocardial Stunning Drug: Ranolazine|Drug: Placebo Policlinico Universitario Agostino Gemelli Phase 4 2016-10-01 2016-08-19

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

  • 相关化合物库

  • 使用AMQUAR产品发表文献后请联系我们

相关推荐

X
  • 联系人 ：
  • 收件地址 ：
  • 电话号码 ：
  • 单位名称 ：
  • 产品货号 ：
  • 产品规格 ：
  • 发票抬头以及单位税号 ：