Albendazole属于苯并咪唑类化合物,可抗蠕虫感染。
Albendazole is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Whittaker SG, et al. Toxicol Appl Pharmacol,?991, 109(1), 73-84.
分子式 C12H15N3O2S |
分子量 265.33 |
CAS号 54965-21-8 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 16 mg/mL |
Water <1 mg/mL |
Ethanol <1 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT02784743 | Lymphatic Filariasis | Drug: ''albendazole'' and ''ivermectin'' | Centre d'Appui la lutte contre la Maladie|Malaria Research and Training Center, Bamako, Mali|World Health Organization | Phase 4 | 2001-05-01 | 2016-05-24 |
NCT01087099 | Infections With Soil-Transmitted Helminths (STH) | Drug: Albendazole | University Ghent|Ghent University, Faculty of Veterinary Medicine, Dpt of Virology, Parasitology and Immunology, Belgium|World Health Organization|George Washington University|Commonwealth Scientific and Industrial Research Organisation, Australia|University of Nottingham|Queensland Institute of Medical Research | Phase 4 | 2009-01-01 | 2011-07-30 |
NCT02243644 | Neurocysticercosis | Drug: 7 days of albendazole 15 mg/kg/day|Drug: 28 days of albendazole 15 mg/kg/day | All India Institute of Medical Sciences, New Delhi | Phase 3 | 2014-03-01 | 2015-12-31 |
NCT00511004 | Lymphatic Filariasis | Drug: Albendazole|Drug: Diethylcarbamazine | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) | Phase 2 | 2007-07-01 | 2015-07-30 |
NCT00755560 | Toxocariasis | Drug: Albendazole|Drug: Placebo | Hospital de Nios R. Gutierrez de Buenos Aires|The Hospital for Sick Children | Phase 3 | 2008-09-01 | 2016-02-18 |
NCT01755637 | Helminthiasis | Drug: Albendazole | GlaxoSmithKline | Phase 1 | 2012-04-01 | 2013-07-11 |
NCT00441285 | Neurocysticercosis|Epilepsy | Drug: Praziquantel|Drug: Albendazole|Drug: ABZ Placebo|Drug: PZQ Placebo | Universidad Peruana Cayetano Heredia|National Institute of Neurological Disorders and Stroke (NINDS) | Phase 2|Phase 3 | 2010-01-01 | 2015-05-15 |
NCT00765024 | Chronic Strongyloidiasis | Drug: Ivermectin|Drug: ivermectin|Drug: Albendazole | Mahidol University|Atlantic Laboratory Ltd | Phase 3 | 2008-07-01 | 2010-06-18 |
NCT01192802 | Intestinal Diseases|Helminthiasis | Drug: albendazole|Drug: albendazole|Drug: albendazole | Albert Schweitzer Hospital | Phase 4 | 2010-08-01 | 2013-01-23 |
NCT01213576 | Lymphatic Filariasis | Drug: Albendazole 400mg and ivermectin 200mcg/kg|Drug: Albendazole and ivermectin|Drug: Albendazole 400mg and ivermectin 200mcg/kg|Drug: albendazole 800mg and ivermectin 400mcg/kg bi-annually | London School of Hygiene and Tropical Medicine|Emory University | 2009-01-01 | 2015-02-26 | |
NCT02420574 | Helminthiasis | Drug: albendazole BENDEX|Drug: albendazole OVIS | University Ghent | 2014-02-01 | 2015-04-17 | |
NCT02636803 | Helminthiasis | Drug: oxfendazole|Drug: albendazole | Robert Gilman|Universidad Peruana Cayetano Heredia|Johns Hopkins Bloomberg School of Public Health | Phase 2 | 2017-11-01 | 2017-03-02 |
NCT00002191 | Protozoan Infections|HIV Infections | Drug: Albendazole | SmithKline Beecham|NIH AIDS Clinical Trials Information Service | Phase 3 | 2005-06-23 | |
NCT01440608 | Enteropathy | Drug: Albendazole|Drug: Placebo|Dietary Supplement: High-dose Zinc | Washington University School of Medicine | 2011-10-01 | 2012-03-02 | |
NCT02876146 | Alveolar Echinococcosis | Drug: Benzimidazole | Centre Hospitalier Universitaire de Besancon | 2012-06-01 | 2016-08-22 | |
NCT01975441 | Lymphatic Filariasis | Drug: Diethylcarbamazine|Drug: Albendazole|Drug: Ivermectin | University Hospitals Cleveland Medical Center | Phase 2 | 2014-05-01 | 2016-10-11 |
NCT00659997 | Ascariasis|Trichuriasis | Drug: Albendazole|Drug: Levamisole | Natural History Museum, United Kingdom|Ministry of Health, Tanzania|University of London | Phase 4 | 2006-06-01 | 2008-04-15 |
NCT02845713 | Wuchereria Bancrofti Infection | Drug: Ivermectin, Diethylcarbamazine Albendazole (IDA) | University Hospitals Cleveland Medical Center|Washington University School of Medicine | Phase 1 | 2016-04-01 | 2016-10-11 |
NCT00375583 | Lymphatic Filariasis|Wuchereria Bancrofti Infection | Drug: DEC/Albendazole | National Institute of Allergy and Infectious Diseases (NIAID)|Tuberculosis Research Centre, India|National Institutes of Health Clinical Center (CC) | Phase 2 | 2006-09-09 | 2017-01-24 |
NCT01395381 | Kwashiorkor|Marasmus | Drug: Placebo|Drug: Albendazole | Washington University School of Medicine|University of Malawi College of Medicine | 2013-01-01 | 2014-01-24 | |
NCT00130910 | HIV Infections|Helminthiasis | Drug: Albendazole|Drug: Placebo | University of Washington|Kenya Medical Research Institute|University of Nairobi|Kenyatta National Hospital | 2006-03-01 | 2007-11-13 | |
NCT00207753 | Ascariasis|Trichuriasis|Hookworm Infection|Strongyloidiasis|Pediculosis | Drug: albendazole vs. combined albendazole/ivermectin treatment | Centers for Disease Control and Prevention|Universidad del Valle, Guatemala | 2005-02-01 | 2005-11-16 | |
NCT01903057 | Trachoma|Lymphatic Filariasis | Drug: azithromycin|Drug: ivermectin|Drug: albendazole|Drug: placebo | Emory University | Phase 4 | 2014-02-01 | 2014-05-21 |
NCT00339417 | Lymphatic Filariasis | Drug: Albendazole|Drug: Ivermectin | National Institute of Allergy and Infectious Diseases (NIAID)|National Institutes of Health Clinical Center (CC) | Phase 2 | 2006-02-22 | 2017-01-24 |
NCT03032042 | Helminth Infection | Drug: Azithromycin|Drug: Albendazole|Drug: Delayed treatment | Francis I. Proctor Foundation | Phase 4 | 2017-01-01 | 2017-01-23 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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