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Amantadine HCl

盐酸金刚烷胺,1-adamantanamine HCl

Amantadine hydrochloride是抗流感病毒和抗帕金森病化合物。

目录号
EY1410
EY1410
EY1410
纯度
99.24%
99.24%
99.24%
规格
500 mg
1 g
5 g
原价
290
360
580
售价
290
360
580
库存
现货
现货
现货
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  • 生物活性

    Amantadine HCl is used to treat or prevent infections of the respiratory tract caused by a certain virus.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数


    例如，已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法：将88 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到该药物用于大鼠的等效剂量44 mg/kg。

  • 参考文献

    [1] Changbo Ou et. Al. PLoS ONE, 9(10), e111004 (2014).
    [2] Katarina Spilovska et. Al. Molecules, 18(2), 2397-2418 (2013).
    [3] Tatiana Baranovich et. Al. Antiviral Research, 117, 10-19 (2015).
    [4] Sara Redaelli et. Al. Journal of Hematology & Oncology, 8, 81 (2015).

    分子式
    C10H18ClN    		 分子量
    187.71    		 CAS号
    665-66-7    		 储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂（常温）
    		 DMSO
    38 mg/mL    		 Water
    50 mg/mL    		 Ethanol
    38 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT02153632 Parkinson's Disease|Levodopa Induced Dyskinesia (LID) Drug: Amantadine HCl ER (ALLAY-LID II)|Drug: Placebo Osmotica Pharmaceutical US LLC Phase 3 2014-06-01 2016-02-09
    NCT02153645 Parkinson's Disease|Levodopa Induced Dyskinesias (LID) Drug: Amantadine ER Tablets|Drug: Placebo Tablets for Amantadine ER Tablets Osmotica Pharmaceutical US LLC Phase 3 2014-06-01 2016-02-09
    NCT00975611 Schizophrenia|Schizoaffective Disorder Drug: Amantadine Hydrochloride, USP|Drug: Amantadine Hydrochloride, USP|Drug: Placebo David C. Henderson, MD|Ortho-McNeil Janssen Scientific Affairs, LLC|North Suffolk Mental Health Association Phase 4 2009-10-01 2013-05-03
    NCT02274766 Dyskinesia|Levodopa-Induced Dyskinesia (LID)|Parkinson's Disease (PD) Drug: ADS-5102|Other: Placebo Adamas Pharmaceuticals, Inc. Phase 3 2014-10-01 2016-05-16
    NCT00627250 Irritable Mood|Aggression|Traumatic Brain Injury Drug: Amantadine Carolinas Healthcare System|U.S. Department of Education 2003-03-01 2010-03-23
    NCT02486211 Coma|Heart Arrest|Anoxia Drug: Amantadine|Drug: Placebo University of Pittsburgh|American Heart Association Phase 2 2015-09-01 2017-01-03
    NCT00970944 Traumatic Brain Injury Drug: Amantadine Hydrochloride|Drug: Placebo JFK Medical Center|U.S. Department of Education Phase 2|Phase 3 2003-02-01 2012-09-11
    NCT01652534 Parkinson's Disease Drug: Amantadine|Drug: Placebo Northwestern University Phase 3 2011-06-01 2016-03-30
    NCT00779324 Brain Injury|Aggression Drug: Amantadine Hydrochloride|Drug: Placebo Carolinas Healthcare System|Indiana University|University of Washington|The Institute for Rehabilitaion and Research Foundation|Spaulding Rehabilitation Hospital|Ohio State University|Icahn School of Medicine at Mount Sinai 2009-08-01 2014-08-11
    NCT00287352 Psychotic Disorder|Schizophreniform Disorder|Schizophrenia|Schizoaffective Disorder|Mood Disorders With Psychotic Features Drug: Olanzapine, Amantadine|Drug: Olanzapine and placebo University of North Carolina, Chapel Hill|Eli Lilly and Company Phase 1 2005-05-01 2011-04-29
    NCT01538329 Parkinson Disease Drug: Amantadine|Drug: placebo University Hospital, Toulouse Phase 2 2012-03-01 2016-05-06
    NCT02025439 Traumatic Brain Injury Device: rTMS|Drug: Amantadine Edward Hines Jr. VA Hospital 2014-02-01 2016-04-22
    NCT02202551 Dyskinesia|Levodopa Induced Dyskinesia (LID)|Parkinson's Disease (PD) Drug: ADS-5102 Adamas Pharmaceuticals, Inc. Phase 3 2014-07-01 2016-05-16
    NCT02471222 Walking Impairment|Multiple Sclerosis Drug: ADS-5102|Other: Placebo Adamas Pharmaceuticals, Inc. Phase 2 2015-05-01 2016-12-07
    NCT02321761 Traumatic Brain Injury Drug: Amantadine hydrochloride Loewenstein Hospital Phase 4 2014-06-01 2016-09-26
    NCT02566720 Acquired Brain Injury|Coma|Persistent Vegetative State|Minimally Conscious State|Traumatic Brain Injury Drug: Amantadine|Procedure: MRI Tractography Study Hamilton Health Sciences Corporation 2016-01-01 2015-12-10
    NCT00999505 Schizophrenia Drug: Amantadine|Drug: Placebo Hospital de Clinicas de Porto Alegre Phase 3 2010-05-01 2011-02-15
    NCT02136914 Dyskinesia|Levodopa Induced Dyskinesia (LID)|Parkinson's Disease Drug: ADS-5102|Other: Placebo Adamas Pharmaceuticals, Inc. Phase 3 2014-05-01 2017-02-15
    NCT01190553 Parkinson Disease Drug: Amantadine Rabin Medical Center 2010-11-01 2010-10-10
    NCT00416962 Healthy Drug: amantadine hydrochloride|Drug: oseltamivir phosphate Novartis|Hoffmann-La Roche Phase 1 2006-08-01 2007-11-29
    NCT00600093 Parkinson Disease|Perioperative Care Drug: Amantadine Rabin Medical Center Phase 2 2008-01-01 2011-07-24
    NCT01397422 Dyskinesia|Levodopa Induced Dyskinesia|Parkinson's Disease Drug: ADS-5102 (extended release amantadine HCl) Adamas Pharmaceuticals, Inc. Phase 2|Phase 3 2011-07-01 2017-02-15
    NCT00800514 Traumatic Brain Injury Drug: amantadine|Drug: amantadine Carolinas Healthcare System 2009-01-01 2011-07-18
    NCT00693121 Traumatic Brain Injury|Posttraumatic Confusional State|Delirium Drug: Amantadine hydrochloride|Drug: Placebo capsule Methodist Rehabilitation Center|U.S. Department of Education Phase 4 2003-04-01 2008-06-05
    NCT00950196 Ataxia|Chorea|Dystonia|Parkinsonism|Fatigue Drug: amantadine sulphate Sheba Medical Center Phase 4 2008-11-01 2011-06-26
    NCT01313845 Parkinson's Disease Drug: amantadine sulfate|Drug: 0.9% sodium chloride Jee-Young Lee|Seoul National University Boramae Hospital|Samsung Medical Center|Seoul National University Bundang Hospital|Hanyang University|Seoul National University Hospital Phase 4 2011-02-01 2012-08-08
    NCT01071395 Parkinson's Disease Drug: Amantadine|Drug: Placebo Rush University Medical Center|Michael J. Fox Foundation for Parkinson's Research Phase 4 2010-01-01 2015-05-07

    注：以上所有数据均来自公开文献，并不保证对所有实验均有效，数据仅供参考。

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