Divalproex Sodium是是肠溶包衣中丙戊酸钠和丙戊酸按1:1摩尔组成的化合物。
Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Wang W, et al. Cancer Lett, 2015, 356(2 Pt B), 791-799.
分子式 C8H16O2.C8H15O2.Na |
分子量 310.41 |
CAS号 76584-70-8 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 56 mg/mL |
Water 56 mg/mL |
Ethanol 56 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01898676 | Epilepsy | Drug: Divalproex Sodium Extended-release 250mg|Drug: DEPAKOTE 250mg | Vince & Associates Clinical Research, Inc.|Food and Drug Administration (FDA) | Phase 1 | 2013-07-01 | 2013-07-09 |
NCT01055938 | Healthy | Drug: Divalproex Sodium | Dr. Reddy's Laboratories Limited | Phase 1 | 2006-12-01 | 2010-01-25 |
NCT01056627 | Healthy | Drug: Divalproex Sodium | Dr. Reddy's Laboratories Limited | Phase 1 | 2006-12-01 | 2010-01-25 |
NCT01581788 | Healthy | Drug: Divalproex Sodium | Dr. Reddy's Laboratories Limited | Phase 1 | 2011-01-01 | 2012-04-19 |
NCT01581775 | Healthy | Drug: Divalproex Sodium | Dr. Reddy's Laboratories Limited | Phase 1 | 2011-01-01 | 2012-04-19 |
NCT01132196 | Healthy | Drug: Divalproex Sodium | Dr. Reddy's Laboratories Limited | Phase 1 | 2006-08-01 | 2010-06-11 |
NCT01132170 | Healthy | Drug: Divalproex Sodium | Dr. Reddy's Laboratories Limited | Phase 1 | 2006-08-01 | 2010-06-11 |
NCT01132183 | Healthy | Drug: Divalproex Sodium | Dr. Reddy's Laboratories Limited | Phase 1 | 2007-02-01 | 2010-05-26 |
NCT00176202 | Bipolar Disorder | Drug: Divalproex Sodium|Drug: risperidone | University of Illinois at Chicago | Phase 3 | 2003-04-01 | 2015-11-04 |
NCT00287053 | Healthy | Drug: divalproex sodium | Pennington Biomedical Research Center|Abbott | Phase 4 | 2006-02-01 | 2016-01-15 |
NCT00194025 | Schizophrenia | Drug: Valproate | University Hospitals Cleveland Medical Center|Abbott | Phase 4 | 2004-11-01 | 2014-12-16 |
NCT00194116 | Bipolar Disorder | Drug: Divalproex Sodium ER|Drug: Placebo | University Hospitals Cleveland Medical Center|Abbott | Phase 3 | 2004-09-01 | 2014-12-01 |
NCT00218114 | Attention Deficit and Disruptive Behavior Disorders|Marijuana Abuse | Drug: Divalproex Sodium (Depakote)|Drug: divalproex sodium | New York State Psychiatric Institute|National Institute on Drug Abuse (NIDA) | Phase 3 | 2000-02-01 | 2014-03-06 |
NCT02094651 | Autism | Drug: divalproex sodium|Other: Placebo | Boston Children Hospital|University of Louisville | Phase 2 | 2014-04-01 | 2016-10-20 |
NCT01928849 | Pain, Phantom|Pain, Neuropathic | Drug: Valproic Acid|Other: Cherry Syrup | Duke University|United States Department of Defense | Phase 2 | 2013-12-01 | 2016-08-03 |
NCT01183676 | Healthy | Drug: DEPAKOTE庐 Tablets, 500 MG|Drug: DIVALPROEX SODIUM DELAYED-RELEASE TABLETS, USP, 500 MG | Mylan Pharmaceuticals | Phase 1 | 2007-07-01 | 2010-08-13 |
NCT01184391 | Healthy | Drug: DEPAKOTE庐 Tablets, 500 MG|Drug: DIVALPROEX SODIUM DELAYED-RELEASE TABLETS, USP, 500 MG | Mylan Pharmaceuticals | Phase 1 | 2007-07-01 | 2010-08-17 |
NCT00211796 | Autism | Drug: Divalproex Sodium ER | Icahn School of Medicine at Mount Sinai | Phase 4 | 2005-04-01 | 2007-04-17 |
NCT01738815 | Hematuria|Bladder Cancer | Drug: Valproic Acid | State University of New York - Upstate Medical University | Early Phase 1 | 2011-12-01 | 2012-12-12 |
NCT01094249 | Schizophrenia|Bipolar Disorder|Psychotic Disorders | Drug: divalproex sodium ER/paliperidone ER | Johnson & Johnson Pharmaceutical Research & Development, L.L.C. | Phase 1 | 2009-02-01 | 2014-04-07 |
NCT00315900 | Agitation|Dementia | Drug: Depakote ER|Drug: Seroquel | Tuscaloosa Research & Education Advancement Corporation|Abbott | Phase 3 | 2006-05-01 | 2012-08-30 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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