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Divalproex Sodium

双丙戊酸钠,Valproic Acid Semisodium Salt

Divalproex Sodium是是肠溶包衣中丙戊酸钠和丙戊酸按1:1摩尔组成的化合物。

目录号
EY1408
EY1408
纯度
99.26%
99.26%
规格
500 mg
1 g
原价
365.00
498.00
售价
365.00
498.00
库存
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Divalproex Sodium, consisting of a compound of sodium valproate and valproic acid in a 1:1 molar relationship in an enteric coated form, is a HDAC inhibitor, used in the treatment for epilepsy.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Wang W, et al. Cancer Lett, 2015, 356(2 Pt B), 791-799.

    分子式
    C8H16O2.C8H15O2.Na
    分子量
    310.41
    CAS号
    76584-70-8
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    56 mg/mL
    Water
    56 mg/mL
    Ethanol
    56 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT01898676 Epilepsy Drug: Divalproex Sodium Extended-release 250mg|Drug: DEPAKOTE 250mg Vince & Associates Clinical Research, Inc.|Food and Drug Administration (FDA) Phase 1 2013-07-01 2013-07-09
    NCT01055938 Healthy Drug: Divalproex Sodium Dr. Reddy's Laboratories Limited Phase 1 2006-12-01 2010-01-25
    NCT01056627 Healthy Drug: Divalproex Sodium Dr. Reddy's Laboratories Limited Phase 1 2006-12-01 2010-01-25
    NCT01581788 Healthy Drug: Divalproex Sodium Dr. Reddy's Laboratories Limited Phase 1 2011-01-01 2012-04-19
    NCT01581775 Healthy Drug: Divalproex Sodium Dr. Reddy's Laboratories Limited Phase 1 2011-01-01 2012-04-19
    NCT01132196 Healthy Drug: Divalproex Sodium Dr. Reddy's Laboratories Limited Phase 1 2006-08-01 2010-06-11
    NCT01132170 Healthy Drug: Divalproex Sodium Dr. Reddy's Laboratories Limited Phase 1 2006-08-01 2010-06-11
    NCT01132183 Healthy Drug: Divalproex Sodium Dr. Reddy's Laboratories Limited Phase 1 2007-02-01 2010-05-26
    NCT00176202 Bipolar Disorder Drug: Divalproex Sodium|Drug: risperidone University of Illinois at Chicago Phase 3 2003-04-01 2015-11-04
    NCT00287053 Healthy Drug: divalproex sodium Pennington Biomedical Research Center|Abbott Phase 4 2006-02-01 2016-01-15
    NCT00194025 Schizophrenia Drug: Valproate University Hospitals Cleveland Medical Center|Abbott Phase 4 2004-11-01 2014-12-16
    NCT00194116 Bipolar Disorder Drug: Divalproex Sodium ER|Drug: Placebo University Hospitals Cleveland Medical Center|Abbott Phase 3 2004-09-01 2014-12-01
    NCT00218114 Attention Deficit and Disruptive Behavior Disorders|Marijuana Abuse Drug: Divalproex Sodium (Depakote)|Drug: divalproex sodium New York State Psychiatric Institute|National Institute on Drug Abuse (NIDA) Phase 3 2000-02-01 2014-03-06
    NCT02094651 Autism Drug: divalproex sodium|Other: Placebo Boston Children Hospital|University of Louisville Phase 2 2014-04-01 2016-10-20
    NCT01928849 Pain, Phantom|Pain, Neuropathic Drug: Valproic Acid|Other: Cherry Syrup Duke University|United States Department of Defense Phase 2 2013-12-01 2016-08-03
    NCT01183676 Healthy Drug: DEPAKOTE庐 Tablets, 500 MG|Drug: DIVALPROEX SODIUM DELAYED-RELEASE TABLETS, USP, 500 MG Mylan Pharmaceuticals Phase 1 2007-07-01 2010-08-13
    NCT01184391 Healthy Drug: DEPAKOTE庐 Tablets, 500 MG|Drug: DIVALPROEX SODIUM DELAYED-RELEASE TABLETS, USP, 500 MG Mylan Pharmaceuticals Phase 1 2007-07-01 2010-08-17
    NCT00211796 Autism Drug: Divalproex Sodium ER Icahn School of Medicine at Mount Sinai Phase 4 2005-04-01 2007-04-17
    NCT01738815 Hematuria|Bladder Cancer Drug: Valproic Acid State University of New York - Upstate Medical University Early Phase 1 2011-12-01 2012-12-12
    NCT01094249 Schizophrenia|Bipolar Disorder|Psychotic Disorders Drug: divalproex sodium ER/paliperidone ER Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Phase 1 2009-02-01 2014-04-07
    NCT00315900 Agitation|Dementia Drug: Depakote ER|Drug: Seroquel Tuscaloosa Research & Education Advancement Corporation|Abbott Phase 3 2006-05-01 2012-08-30

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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