Solifenacin Succinate (琥珀酸索利那新; YM905; Vesicare) 是毒蕈碱受体拮抗剂。
Solifenacin succinate is a urinary antispasmodic of the antimuscarinic class.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Ikeda K, et al. Naunyn Schmiedebergs Arch Pharmacol, 2002, 366(2), 97-103.
分子式 C27H32N2O6 |
分子量 480.55 |
CAS号 242478-38-2 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 3 mg/mL |
Water 96 mg/mL |
Ethanol 5 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT01015040 | Bioavailability of Solifenacin Succinate|Pharmacokinetics of Solifenacin Succinate|Healthy Volunteers | Drug: solifenacin succinate suspension|Drug: solifenacin succinate tablet | Astellas Pharma Inc | Phase 1 | 2009-09-01 | 2009-12-04 |
NCT01371994 | Urinary Incontinence | Drug: solifenacin succinate|Drug: Placebo | Astellas Pharma Inc | Phase 4 | 2011-08-01 | 2014-10-06 |
NCT01539707 | Overactive Bladder|Neurogenic Detrusor Overactivity | Drug: Solifenacin succinate | Astellas Pharma Inc | Phase 1 | 2012-03-01 | 2012-10-29 |
NCT00454740 | Urinary Bladder, Overactive | Drug: solifenacin succinate | Astellas Pharma Inc | Phase 3 | 2004-06-01 | 2014-09-17 |
NCT00463541 | Urinary Bladder, Overactive | Drug: solifenacin succinate | Astellas Pharma Inc | Phase 3 | 2004-06-01 | 2014-09-17 |
NCT00773552 | Urinary Urge|Urge Incontinence|Overactive Bladder | Drug: solifenacin succinate|Drug: placebo | Stamford Hospital | Phase 4 | 2008-11-01 | 2016-12-05 |
NCT00985387 | Urinary Bladder, Overactive|Overactive Bladder | Drug: Solifenacin | Astellas Pharma Inc|Astellas Pharma Korea, Inc. | 2009-08-01 | 2011-10-11 | |
NCT01981954 | Neurogenic Detrusor Overactivity|Pediatric | Drug: Solifenacin succinate | Astellas Pharma Europe B.V.|Astellas Pharma Inc | Phase 3 | 2013-09-01 | 2016-06-02 |
NCT00507455 | Lower Urinary Tract Symptoms|Bladder Outlet Obstruction | Drug: solifenacin succinate|Drug: tamsulosin hydrochloride|Drug: Placebo to solifenacin|Drug: Placebo to tamsulosin | Astellas Pharma Inc | Phase 2 | 2007-06-01 | 2014-07-14 |
NCT01565707 | Urinary Bladder, Overactive | Drug: Solifenacin Succinate Suspension|Drug: Placebo|Behavioral: Urotherapy | Astellas Pharma Europe B.V.|Astellas Pharma Inc | Phase 3 | 2012-06-01 | 2016-12-05 |
NCT01777217 | Over-Active Bladder | Drug: Solifenacin succinate|Drug: Placebo | Advanced Research Network|Astellas Pharma US, Inc. | Phase 4 | 2013-02-01 | 2015-01-08 |
NCT01833663 | Overactive Bladder|Postmenopausal Disorder|Urination Disorders | Drug: Solifenacin Succinate Tablets|Drug: Estrogen | Peking Union Medical College Hospital|Astellas Pharma China, Inc.|Beijing CAT Science Co., Ltd. | Phase 4 | 2011-10-01 | 2014-03-19 |
NCT01655069 | Urinary Bladder, Overactive | Drug: Solifenacin succinate | Astellas Pharma Europe B.V.|Astellas Pharma Inc | Phase 3 | 2012-10-01 | 2015-07-23 |
NCT01406158 | Pharmacokinetics of Solifenacin Succinate|Healthy Volunteers | Drug: Solifenacin Succinate Formulation A|Drug: Solifenacin Succinate Formulation B|Drug: Solifenacin Succinate | Astellas Pharma Inc | Phase 1 | 2011-05-01 | 2011-08-23 |
NCT01595152 | Urinary Bladder, Overactive | Drug: solifenacin succinate|Drug: fesoterodine | Rambam Health Care Campus | 2012-05-01 | 2012-05-14 | |
NCT00454896 | Urinary Bladder, Overactive | Drug: VESIcare|Drug: placebo | Astellas Pharma Inc | Phase 3 | 2004-05-01 | 2014-09-17 |
NCT01565694 | Neurogenic Detrusor Overactivity | Drug: Solifenacin succinate | Astellas Pharma Europe B.V.|Astellas Pharma Inc | Phase 3 | 2012-09-01 | 2016-07-24 |
NCT01093534 | Detrusor Overactivity|Overactive Bladder | Drug: Placebo|Drug: solifenacin | Astellas Pharma Inc | Phase 4 | 2010-01-01 | 2017-02-15 |
NCT00337558 | Overactive Bladder|Urinary Incontinence|Urge Incontinence | Drug: Solifenacin succinate|Behavioral: Simplified bladder training | Astellas Pharma Inc|Astellas Pharma Europe B.V. | Phase 4 | 2006-05-01 | 2014-09-17 |
NCT02010944 | Phase 1|Bioavailability|Healthy Subjects | Drug: solifenacin succinate|Drug: mirabegron|Drug: mirabegron/solifenacin succinate | Astellas Pharma Europe B.V.|Astellas Pharma Inc | Phase 1 | 2012-09-01 | 2013-12-10 |
NCT00884104 | Overactive Bladder | Drug: Solifenacin | KYU-SUNG LEE|Astellas Pharma Korea, Inc.|Samsung Medical Center | Phase 4 | 2009-03-01 | 2016-01-06 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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