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Telbivudine

特必夫定,Epavudine,L-Thymidine,NV 02B,Sebivo,NV-02B,NV02B,

Telbivudine 是一种抗病毒药,用于治疗乙型肝炎感染。

目录号
EY1395
EY1395
EY1395
EY1395
纯度
99.33%
99.33%
99.33%
99.33%
规格
5 mg
10 mg
50 mg
100 mg
原价
330
520
1200
2200
售价
330
520
1200
2200
库存
现货
现货
现货
现货
订购
订购
订购
订购
订购
订购
  • 生物活性

    Telbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection.

  • 体外研究

  • 体内研究

  • 激酶实验

  • 细胞实验

  • 动物实验

  • 不同实验动物依据体表面积的等效剂量转换表(数据来源于FDA指南)

    动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 AKm系数


    例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。


  • 参考文献

    [1] Bridges EG, et al. Antimicrob Agents Chemother, 2008, 52(7), 2521-2528.

    分子式
    C10H14N2O5
    分子量
    242.23
    CAS号
    3424-98-4
    储存方式
    ﹣20 ℃冷藏长期储存。冰袋运输
    溶剂(常温)
    DMSO
    48 mg/mL
    Water
    48 mg/mL
    Ethanol
    2 mg/mL

    体内溶解度

  • Clinical Trial Information ( data from http://clinicaltrials.gov )

    NCT Number Conditions Interventions Sponsor/Collaborators Phases Start Date Last Updated
    NCT00939068 Chronic Hepatitis B, Gestation Drug: Telbivudine|Biological: engineered HB vaccine Southeast University, China Phase 4 2008-02-01 2009-10-13
    NCT01380951 Liver Cirrhosis|Chronic Hepatitis B Drug: telbivudine The Fifth People's Hospital of Suzhou Phase 4 2011-05-01 2011-06-23
    NCT02058108 Chronic Hepatitis B Drug: Telbivudine|Drug: Placebo Novartis Pharmaceuticals|Novartis Phase 3 2014-10-31 2017-02-14
    NCT00646503 Hepatitis B, Chronic Drug: Telbivudine Novartis Phase 4 2008-03-01 2016-11-16
    NCT01379508 Chronic Hepatitis B Drug: Telbivudine 600mg|Drug: Tenofovir disoproxil fumarate 300mg Novartis Pharmaceuticals|Novartis Phase 4 2011-03-01 2016-04-20
    NCT00142298 Chronic Hepatitis B Drug: Telbivudine (LdT) Novartis Pharmaceuticals|Merck Sharp & Dohme Corp.|Novartis Phase 3 2005-03-01 2015-03-24
    NCT01637844 HBV Drug: Telbivudine Yi-Hua Zhou|Taixing People's Hospital|Fourth People's Hospital of Zhenjiang, China|Wuxi Maternal and Child Health Hospital|Kunshan First People Hospital|The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School Phase 4 2012-04-01 2014-11-30
    NCT02894554 HBsAg-positive Renal Allograft Recipients Drug: Telbivudine|Drug: Lamivudine National Taiwan University Hospital Phase 4 2014-07-01 2016-09-05
    NCT01260610 Chronic Hepatitis B Drug: Tenofovir|Drug: Telbivudine|Drug: Tenofovir plus Telbivudine Institute of Liver and Biliary Sciences, India 2011-06-01 2015-06-15
    NCT01595685 Chronic Viral Hepatitis B Without Delta-agent Drug: Telbivudine|Drug: Entecavir Asan Medical Center Phase 3 2012-05-01 2017-01-24
    NCT00467545 Chronic Hepatitis B Drug: telbivudine Novartis Pharmaceuticals|Novartis Phase 4 2007-04-01 2012-05-07
    NCT01743079 Chronic Hepatitis B|Late Pregnancy|Transmission|Complication Drug: Telbivudine|Drug: Lamivudine Beijing YouAn Hospital|New Discovery LLC Phase 4 2009-01-01 2013-07-29
    NCT02447705 Disorder Related to Transplantation|Virus Diseases|Injury Due to Exposure to External Cause Drug: telbivudine Chang Gung Memorial Hospital Phase 2|Phase 3 2013-06-01 2017-02-05
    NCT00970216 Chronic Hepatitis B Drug: Telbivudine Chang Gung Memorial Hospital 2009-02-01 2016-01-31
    NCT00076336 Hepatitis|Hepatitis B, Chronic|Cirrhosis Drug: Telbivudine|Drug: Lamivudine|Drug: Placebo Novartis Pharmaceuticals|Novartis Phase 3 2003-12-01 2011-08-04
    NCT00412750 Hepatitis B Drug: Telbivudine (LdT)|Drug: peginterferon alpha-2a Novartis Phase 3 2006-12-01 2011-06-14
    NCT02049736 Chronic Hepatitis B Drug: Telbivudine Chinese University of Hong Kong 2013-12-01 2016-07-26
    NCT00537537 Hepatitis B, Chronic Drug: Telbivudine Novartis Pharmaceuticals|Novartis Phase 4 2007-08-01 2016-04-20
    NCT01804387 Chronic Hepatitis B Drug: telbivudine plus adefovir|Drug: lamivudine plus adefovir Korea University Phase 4 2011-05-01 2013-03-03
    NCT02774837 Chronic Hepatitis B Drug: Tenofovir disoproxil|Drug: Telbivudine Seng Gee Lim|National Medical Research Council (NMRC), Singapore|Singapore Clinical Research Institute|National University Health System, Singapore Phase 4 2016-05-01 2016-05-16
    NCT00651209 Hepatitis B, Chronic Drug: Tenofovir Novartis Pharmaceuticals|Novartis Phase 4 2008-02-01 2014-03-06
    NCT00962533 Hepatitis B, Chronic Drug: telbivudine|Drug: telbivudine Nanfang Hospital of Southern Medical University|Major Science and Technology Special Project of China Eleventh Five-year|Novartis Phase 4 2009-08-01 2013-01-29
    NCT01337791 Chronic Hepatitis B|Pregnancy Complications|High Viral Load|Elevated Alanine Aminotransferase Levels Drug: Telbivudine treatment Southeast University, China Phase 4 2008-08-01 2011-04-18

    注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。

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