Telbivudine 是一种抗病毒药,用于治疗乙型肝炎感染。
Telbivudine is a potent, and selective HBV reverse transcriptase inhibitor, used to treat HBV infection.
动物 A (mg/kg) = 动物 B (mg/kg)×动物 B的Km系数/动物 A的Km系数 | |
例如,已知某工具药用于小鼠的剂量为88 mg/kg , 则用于大鼠的剂量换算方法:将88 mg/kg 乘以小鼠的Km系数(3),再除以大鼠的Km系数(6),得到该药物用于大鼠的等效剂量44 mg/kg。
[1] Bridges EG, et al. Antimicrob Agents Chemother, 2008, 52(7), 2521-2528.
分子式 C10H14N2O5 |
分子量 242.23 |
CAS号 3424-98-4 |
储存方式 ﹣20 ℃冷藏长期储存。冰袋运输 |
溶剂(常温) |
DMSO 48 mg/mL |
Water 48 mg/mL |
Ethanol 2 mg/mL |
体内溶解度
NCT Number | Conditions | Interventions | Sponsor/Collaborators | Phases | Start Date | Last Updated |
NCT00939068 | Chronic Hepatitis B, Gestation | Drug: Telbivudine|Biological: engineered HB vaccine | Southeast University, China | Phase 4 | 2008-02-01 | 2009-10-13 |
NCT01380951 | Liver Cirrhosis|Chronic Hepatitis B | Drug: telbivudine | The Fifth People's Hospital of Suzhou | Phase 4 | 2011-05-01 | 2011-06-23 |
NCT02058108 | Chronic Hepatitis B | Drug: Telbivudine|Drug: Placebo | Novartis Pharmaceuticals|Novartis | Phase 3 | 2014-10-31 | 2017-02-14 |
NCT00646503 | Hepatitis B, Chronic | Drug: Telbivudine | Novartis | Phase 4 | 2008-03-01 | 2016-11-16 |
NCT01379508 | Chronic Hepatitis B | Drug: Telbivudine 600mg|Drug: Tenofovir disoproxil fumarate 300mg | Novartis Pharmaceuticals|Novartis | Phase 4 | 2011-03-01 | 2016-04-20 |
NCT00142298 | Chronic Hepatitis B | Drug: Telbivudine (LdT) | Novartis Pharmaceuticals|Merck Sharp & Dohme Corp.|Novartis | Phase 3 | 2005-03-01 | 2015-03-24 |
NCT01637844 | HBV | Drug: Telbivudine | Yi-Hua Zhou|Taixing People's Hospital|Fourth People's Hospital of Zhenjiang, China|Wuxi Maternal and Child Health Hospital|Kunshan First People Hospital|The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | Phase 4 | 2012-04-01 | 2014-11-30 |
NCT02894554 | HBsAg-positive Renal Allograft Recipients | Drug: Telbivudine|Drug: Lamivudine | National Taiwan University Hospital | Phase 4 | 2014-07-01 | 2016-09-05 |
NCT01260610 | Chronic Hepatitis B | Drug: Tenofovir|Drug: Telbivudine|Drug: Tenofovir plus Telbivudine | Institute of Liver and Biliary Sciences, India | 2011-06-01 | 2015-06-15 | |
NCT01595685 | Chronic Viral Hepatitis B Without Delta-agent | Drug: Telbivudine|Drug: Entecavir | Asan Medical Center | Phase 3 | 2012-05-01 | 2017-01-24 |
NCT00467545 | Chronic Hepatitis B | Drug: telbivudine | Novartis Pharmaceuticals|Novartis | Phase 4 | 2007-04-01 | 2012-05-07 |
NCT01743079 | Chronic Hepatitis B|Late Pregnancy|Transmission|Complication | Drug: Telbivudine|Drug: Lamivudine | Beijing YouAn Hospital|New Discovery LLC | Phase 4 | 2009-01-01 | 2013-07-29 |
NCT02447705 | Disorder Related to Transplantation|Virus Diseases|Injury Due to Exposure to External Cause | Drug: telbivudine | Chang Gung Memorial Hospital | Phase 2|Phase 3 | 2013-06-01 | 2017-02-05 |
NCT00970216 | Chronic Hepatitis B | Drug: Telbivudine | Chang Gung Memorial Hospital | 2009-02-01 | 2016-01-31 | |
NCT00076336 | Hepatitis|Hepatitis B, Chronic|Cirrhosis | Drug: Telbivudine|Drug: Lamivudine|Drug: Placebo | Novartis Pharmaceuticals|Novartis | Phase 3 | 2003-12-01 | 2011-08-04 |
NCT00412750 | Hepatitis B | Drug: Telbivudine (LdT)|Drug: peginterferon alpha-2a | Novartis | Phase 3 | 2006-12-01 | 2011-06-14 |
NCT02049736 | Chronic Hepatitis B | Drug: Telbivudine | Chinese University of Hong Kong | 2013-12-01 | 2016-07-26 | |
NCT00537537 | Hepatitis B, Chronic | Drug: Telbivudine | Novartis Pharmaceuticals|Novartis | Phase 4 | 2007-08-01 | 2016-04-20 |
NCT01804387 | Chronic Hepatitis B | Drug: telbivudine plus adefovir|Drug: lamivudine plus adefovir | Korea University | Phase 4 | 2011-05-01 | 2013-03-03 |
NCT02774837 | Chronic Hepatitis B | Drug: Tenofovir disoproxil|Drug: Telbivudine | Seng Gee Lim|National Medical Research Council (NMRC), Singapore|Singapore Clinical Research Institute|National University Health System, Singapore | Phase 4 | 2016-05-01 | 2016-05-16 |
NCT00651209 | Hepatitis B, Chronic | Drug: Tenofovir | Novartis Pharmaceuticals|Novartis | Phase 4 | 2008-02-01 | 2014-03-06 |
NCT00962533 | Hepatitis B, Chronic | Drug: telbivudine|Drug: telbivudine | Nanfang Hospital of Southern Medical University|Major Science and Technology Special Project of China Eleventh Five-year|Novartis | Phase 4 | 2009-08-01 | 2013-01-29 |
NCT01337791 | Chronic Hepatitis B|Pregnancy Complications|High Viral Load|Elevated Alanine Aminotransferase Levels | Drug: Telbivudine treatment | Southeast University, China | Phase 4 | 2008-08-01 | 2011-04-18 |
注:以上所有数据均来自公开文献,并不保证对所有实验均有效,数据仅供参考。
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